Título: Post Doctor
E-mail: [email protected]
Lattes: http://lattes.cnpq.br/2069814538238357
Orcid: ID 0000-0001-7559-4542 – https://orcid.org/0000-0001-7559-4542
Scopus: ID 6602886287 – https://www.scopus.com/authid/detail.uri?authorId=660288628
Google Scholar: ID bBBBYPIAAAAJ – https://scholar.google.com.br/citations?user=bBBBYPIAAAAJ&hl=pt-BR&oi=ao
Research ID: H-5133-2017 – https://publons.com/researcher/2112304/walcy-rosolia-teodoro/
Line of research:
Tissue and molecular aspects of the structure and function of extracellular matrix proteins in inflammatory and fibrotic processes
Summary:
The objective of our line of research is to investigate tissue and molecular aspects of the structure and function of extracellular matrix proteins, with emphasis on the different isoforms of collagen. It is known that collagen, in addition to being responsible for tissue structure, performs functions of cell adhesion, proliferation and migration and that together with the glycoproteins of the cell membrane can promote cellular signaling and immunogenicity. Uncontrolled gene expression synthesis from post-transcriptional changes or changes in essential transcription factors leads to defects in the differentiation and proliferation of cells that culminate in the activation of inflammatory and fibrotic processes present in degenerative autoimmune and osteoarticular diseases. Our proposal is to evaluate the inflammatory and osteoarticular process control mechanisms that culminate in the activation of the inflammatory process and cell proliferation and differentiation “in vitro” and “in vivo” in animals and humans, focusing on the applicability of the knowledge generated to future therapeutic and diagnostic tools.
Relevant articles:
- Barbosa AP, Lourenço JD, Junqueira JJM, Larissa Emidio de França S, Martins JS, Oliveira Junior MC, Begalli I, Velosa APP, Olivo CR, Bastos TB, Jorgetti V, Rodolfo de Paula V, Teodoro WR, Lopes FDTQS. The deleterious effects of smoking in bone mineralization and fibrillar matrix composition. Life Sci. 2020;241:117132. doi: 10.1016/j.lfs.2019.117132.
- Teodoro WR, de Jesus Queiroz ZA, Dos Santos LA, Catanozi S, Dos Santos Filho A, Bueno C, Vendramini MBG, Fernezlian SM, Eher EM, Sampaio-Barros PD, Pasoto SG, Lopes FDTQS, Velosa APP, Capelozzi VL. Proposition of a novel animal model of systemic sclerosis induced by type V collagen in C57BL/6 mice that reproduces fibrosis, vasculopathy and autoimmunity. Arthritis Res Ther. 2019 ;21(1):278. doi: 10.1186/s13075-019-2052-2.
- Atayde SR, Velosa APP, Catanozi S, Del Bianco V, Andrade PC, Rodrigues JECM, Dos Santos Filho A, Antonangelo L, de Mello SBV, Capelozzi VL, Teodoro WR. Collagen V oral administration decreases inflammation and remodeling of synovial membrane in experimental arthritis. PLoS One. 2018 Jul 30;13(7):e0201106. doi: 10.1371/journal.pone.0201106.
- Akamatsu FE, Saleh SO, Hojaij F, Martinez CA, Andrade M, Teodoro WR, Jacomo AL. Radiofrequency preserves histoarchitecture and enhances collagen synthesis in experimental tendon injury. Histol Histopathol. 2016 May;31(5):515-22.
- Atayde SA, Yoshinari NH, Nascimento DP, Catanozi S, Andrade PC, Velosa AP, Parra ER, Passarelli M, Nakandakare ER, Capelozzi VL, Teodoro WR. Experimental diabetes modulates collagen remodelling of joints in rats. Histol Histopathol. 2012 Nov;27(11):1471-9. doi: 10.14670/HH-27.1471.