Títle: Doctor
E-mail: [email protected]; [email protected]
Lattes: http://lattes.cnpq.br/9594814052009112
Orcid: 0000-0001-7991-0231 https://orcid.org/0000-0001-7991-0231
Scopus: ID25654883800 https://www.scopus.com/authid/detail.uri?authorId=25654883800
Google Scholar: ID boX7j0QAAAAJ https://scholar.google.com.br/citations?hl=pt-BR&user=boX7j0QAAAAJ
Research ID:HLQ-7587-2023 http://www.webofscience.com/wos/author/record/[HLQ-7587-2023]
Line of research
– Osteoporosis and Osteometabolism in the general population and in rheumatological diseases
– Sarcopenia and Body Composition (elderly and in rheumatological diseases)
– Fibromyalgia and Chronic Pain with focus on rheumatological diseases
Summary
Bone Metabolism Laboratory of the Rheumatology Division is dedicated to the clinical and experimental study of bone metabolism and osteoporosis, focusing on epidemiology of osteoporosis and evaluation of bone health and body composition/sarcopenia in patients with rheumatological diseases and also in the general population. The lab is equipped with different devices, including densitometry with Vertebral Fracture Assessment (VFA), measurement of visceral fat and Trabecular Bone Score (TBS) softwares. In addition, we have two multi-user equipment (Peripheral high-resolution computed tomography [HR-pQCT] and high-resolution video system [Osteomeasure]) used in the study of bone microarchitecture and quantitative analysis of bone fragments (histomorphometry) obtained by biopsy, respectively. We have clinical studies in patients from the entire hospital complex (Hospital das Clínicas), epidemiological studies (more than 10-year follow-up) of a Brazilian community-dwelling elderly (Sao Paulo Ageing & Health – SPAH) and molecular analyzes of gene expression and polymorphisms genetics in osteoporosis.
Relevant articles
Domiciano DS, Machado LG, Lopes JB, Figueiredo CP, Caparbo VF, Oliveira RM, Scazufca M, McClung MR, Pereira RM. Bone Mineral Density and Parathyroid Hormone as Independent Risk Factors for Mortality in Community-Dwelling Older Adults: A Population-Based Prospective Cohort Study in Brazil. The São Paulo Ageing & Health (SPAH) Study. J Bone Miner Res. 2016;31(6):1146-57. doi: 10.1002/jbmr.2795.
Domiciano DS, Machado LG, Figueiredo CP, Caparbo VF, Oliveira RM, Menezes PR, Pereira RMR. Incidence and risk factors for osteoporotic non-vertebral fracture in low-income community-dwelling elderly: a population-based prospective cohort study in Brazil. The São Paulo Ageing and Health (SPAH) study. Osteoporos Int. 2021;32(4):747-757. doi: 10.1007/s00198-020-05669-6.
Carvalho GD, Bonfiglioli K, Caparbo VF, Takayama L, Pereira RMR, Domiciano DS. Changes to Body Composition in Women With Long-Standing Established Rheumatoid Arthritis: Differences by Level of Disease Activity. J Clin Densitom. 2020;23(4):639-646. doi: 10.1016/j.jocd.2019.06.002.
Domiciano DS, Figueiredo CP, Lopes JB, Kuroishi ME, Takayama L, Caparbo VF, Fuller P, Menezes PF, Scazufca M, Bonfa E, Pereira RM. Vertebral fracture assessment by dual X-ray absorptiometry: a valid tool to detect vertebral fractures in community-dwelling older adults in a population-based survey. Arthritis Care Res (Hoboken). 2013;65(5):809-15. doi: 10.1002/acr.21905.
Domiciano DS, Figueiredo CP, Lopes JB, Caparbo VF, Takayama L, Menezes PR, Bonfa E, Pereira RM. Discriminating sarcopenia in community-dwelling older women with high frequency of overweight/obesity: the São Paulo Ageing & Health Study (SPAH). Osteoporos Int. 2013;24(2):595-603. doi: 10.1007/s00198-012-2002-1.