Título: Associate Professor
E-mail: [email protected]
Lattes: http://lattes.cnpq.br/7705881205786732
Orcid: ID 0000-0002-7797-5274 –   https://orcid.org/0000-0002-7797-5274
Scopus: ID  6508026949 – https://www.scopus.com/authid/detail.uri?authorId=6508026949
Google Scholar: ID Gm8toh4AAAAJ  –  https://scholar.google.com.br/citations?hl=pt-BR&user=Gm8toh4AAAAJ
Research ID: K-1841-2016 – https://publons.com/researcher/2243275/alexandre-f-cristante/

 

Line of research: 

Main: Spinal cord trauma, Spinal deformities, Minimally invasive techniques for spine surgery

Letran – a specialized laboratory for experimental research in the area of nerve repair and reconstruction. Implemented, standardized and validated an experimental spinal cord injury model in Wistar rats. Letran has a computerized drop weight impact tester (New York Impactor) to produce standardized and reproducible spinal contusions, developed by New York University, USA, and adopted by the Multicenter Animal Spinal Cord Injury Study – MASCIS, coordinated by Prof. Wise Young of Rutgers University, USA. Currently, it is developing new therapeutic techniques using stem cells, growth factors and tissue engineering. It is one of Cenatra’s main advanced research facilities. We are developing new ways to evaluate motor recovery in rats, developing devices for the rehabilitation of the rats to assess its importance in recovery from spinal cord injury, and we are entering into partnerships with other laboratories in order to continuously improve our research.

Cenatra – Center of Reference for the Integrated Specialized Care of Spinal Cord Trauma. Line of work: Nuclear, multicenter, interinstitutional, multidisciplinary and multiprofessional program for tertiary and quaternary medical and paramedical care of patients suffering from spinal cord trauma. It offers undergraduate and lato and stricto sensu graduate courses in basic and applied clinical and technological research, and training in technology, human resources, and guidance and dissemination of knowledge to the community. It also foresees offering pre- (prevention campaigns, etc.) and post-hospital (self-care, informal caregiver, socioeconomic re-inclusion, etc.) activities.

Relevant articles:

  1. Paschon V, Correia FF, Morena BC, da Silva VA, Dos Santos GB, da Silva MCC, Cristante AF, Willerth SM, Perrin FE, Kihara AH. CRISPR, Prime Editing, Optogenetics, and DREADDs: New Therapeutic Approaches Provided by Emerging Technologies in the Treatment of Spinal Cord Injury. Mol Neurobiol. 2020 Apr;57(4):2085-2100.
  2. Paschon V, Morena BC, Correia FF, Beltrame GR, Dos Santos GB, Cristante AF, Kihara AH. VDAC1 is essential for neurite maintenance and the inhibition of its oligomerization protects spinal cord from demyelination and facilitates locomotor function recovery after spinal cord injury. Sci Rep. 2019 Oct 1;9(1):14063.
  3. Petersen PA, Marcon RM, Letaif OB, Mello Santos MA, Oliveira RG, Passos de Barros Filho TE, Cristante AF. Does Kyphectomy Improve the Quality of Life of Patients With  yelomeningocele? Clin Orthop Relat Res. 2020 Jan;478(1):104-111.
  4. Barros AGC, Cristante AF, Santos GBD, Natalino RJM, Ferreira RJR, Barros-Filho TEP. Evaluation of the effects of erythropoietin and interleukin-6 in rats submitted to acute spinal cord injury. Clinics (Sao Paulo). 2019;74:e674.
  5. Huang H, Sun T, Chen L, Moviglia G, Chernykh E, von Wild K, Deda H, Kang KS, Kumar A, Jeon SR, Zhang S, Brunelli G, Bohbot A, Soler MD, Li J, Cristante AF, Xi H, Onose G, Kern H, Carraro U, Saberi H, Sharma HS, Sharma A, He X, Muresanu D, Feng S, Otom A, Wang D, Iwatsu K, Lu J, Al-Zoubi A. Consensus of clinical neurorestorative progress in patients with complete chronic spinal cord injury. Cell Transplant. 2014;23 Suppl 1:S5-17.