{"id":728,"date":"2020-07-07T21:26:48","date_gmt":"2020-07-08T00:26:48","guid":{"rendered":"http:\/\/www.musculoesqueleticousp.com.br\/?page_id=728"},"modified":"2024-06-18T16:58:01","modified_gmt":"2024-06-18T19:58:01","slug":"walcy-paganelli-rosolia-teodoro","status":"publish","type":"page","link":"https:\/\/www.musculoesqueleticousp.com.br\/es\/pesquisas\/orientadores\/walcy-paganelli-rosolia-teodoro\/","title":{"rendered":"Walcy Paganelli Rosolia Teodoro"},"content":{"rendered":"

\"\"<\/strong><\/p>\n

T\u00edtulo:<\/strong>\u00a0Postdoctorado
\nE-mail: <\/strong>walcy.teodoro@fm.usp.br<\/a>
\nLattes:\u00a0<\/strong>http:\/\/lattes.cnpq.br\/2069814538238357<\/a>
\nOrcid: <\/strong>ID \u00a0<\/strong>0000-0001-7559-4542 – https:\/\/orcid.org\/0000-0001-7559-4542<\/a>
\nScopus:\u00a0<\/strong>ID 6602886287 – https:\/\/www.scopus.com\/authid\/detail.uri?authorId=660288628<\/a>
\nGoogle Scholar: <\/strong>ID bBBBYPIAAAAJ – https:\/\/scholar.google.com.br\/citations?user=bBBBYPIAAAAJ&hl=pt-BR&oi=ao<\/a>
\nResearch ID:\u00a0<\/strong>H-5133-2017 – https:\/\/publons.com\/researcher\/2112304\/walcy-rosolia-teodoro\/<\/a><\/p>\n

L\u00ednea de investigaci\u00f3n:<\/strong><\/h2>\n

Aspectos tisulares y moleculares de la estructura y funci\u00f3n de las prote\u00ednas de la matriz extracelular en procesos inflamatorios y fibr\u00f3ticos.<\/p>\n

Resumen:<\/strong><\/h2>\n

El objetivo de nuestra l\u00ednea de investigaci\u00f3n es investigar aspectos tisulares y moleculares de la estructura y funci\u00f3n de las prote\u00ednas de la matriz extracelular, con \u00e9nfasis en las diferentes isoformas de col\u00e1geno. Se sabe que el col\u00e1geno, adem\u00e1s de ser responsable por la estructura de los tejidos, presenta las funciones de adhesi\u00f3n, proliferaci\u00f3n y migraci\u00f3n celular, y que juntamente con glicoprote\u00ednas de la membrana celular puede promover se\u00f1alizaci\u00f3n celular e inmunogenicidad. El descontrol de la s\u00edntesis de la expresi\u00f3n g\u00e9nica por cambios postranscripcionales, o alteraciones en factores de transcripci\u00f3n esenciales, lleva a defectos en la diferenciaci\u00f3n y proliferaci\u00f3n de las c\u00e9lulas que culminan en la activaci\u00f3n de procesos inflamatorios y fibr\u00f3ticos presentes en las enfermedades autoinmunes y osteoarticulares degenerativas. Nuestra propuesta es evaluar los mecanismos de control de los procesos inflamatorios y osteoarticulares que culminan en la activaci\u00f3n del proceso inflamatorio, proliferaci\u00f3n y diferenciaci\u00f3n celular \u201cin vitro\u201d e \u201cin vivo\u201d en animales y humanos, buscando la aplicabilidad de los conocimientos generados en futuras herramientas terap\u00e9uticas y diagn\u00f3sticas.<\/p>\n

Art\u00edculos relevantes:
\n<\/strong><\/h2>\n
    \n
  1. Barbosa AP, Louren\u00e7o JD, Junqueira JJM, Larissa Emidio de Fran\u00e7a S, Martins JS, Oliveira Junior MC, Begalli I, Velosa APP, Olivo CR, Bastos TB, Jorgetti V, Rodolfo de Paula V, Teodoro WR, Lopes FDTQS. The deleterious effects of smoking in bone mineralization and fibrillar matrix composition. Life Sci. 2020;241:117132. doi: 10.1016\/j.lfs.2019.117132.<\/li>\n
  2. Teodoro WR, de Jesus Queiroz ZA, Dos Santos LA, Catanozi S, Dos Santos Filho A, Bueno C, Vendramini MBG, Fernezlian SM, Eher EM, Sampaio-Barros PD, Pasoto SG, Lopes FDTQS, Velosa APP, Capelozzi VL. Proposition of a novel animal model of systemic sclerosis induced by type V collagen in C57BL\/6 mice that reproduces fibrosis, vasculopathy and autoimmunity. Arthritis Res Ther. 2019 ;21(1):278. doi: 10.1186\/s13075-019-2052-2.<\/li>\n
  3. Atayde SR, Velosa APP, Catanozi S, Del Bianco V, Andrade PC, Rodrigues JECM, Dos Santos Filho A, Antonangelo L, de Mello SBV, Capelozzi VL, Teodoro WR. Collagen V oral administration decreases inflammation and remodeling of synovial membrane in experimental arthritis. PLoS One. 2018 Jul 30;13(7):e0201106. doi: 10.1371\/journal.pone.0201106.<\/li>\n
  4. Akamatsu FE, Saleh SO, Hojaij F, Martinez CA, Andrade M, Teodoro WR, Jacomo AL. Radiofrequency preserves histoarchitecture and enhances collagen synthesis in experimental tendon injury. Histol Histopathol. 2016 May;31(5):515-22.<\/li>\n
  5. Atayde SA, Yoshinari NH, Nascimento DP, Catanozi S, Andrade PC, Velosa AP, Parra ER, Passarelli M, Nakandakare ER, Capelozzi VL, Teodoro WR. Experimental diabetes modulates collagen remodelling of joints in rats. Histol Histopathol. 2012 Nov;27(11):1471-9. doi: 10.14670\/HH-27.1471.<\/li>\n<\/ol>\n

    PROJETOS ORIENTADOR\/ LINHA<\/strong><\/h2>\n

    Linha 4. OSTEOIMUNOLOGIA E AVALIA\u00c7\u00c3O DOS PROCESSOS DE REGENERA\u00c7\u00c3O M\u00daSCULOESQUEL\u00c9TICA
    \n<\/strong>PROJETO WALCY TEODORO:<\/strong> ESTUDOS DA REATIVIDADE DOS COMPONENTES DA MATRIZ EXTRACELULAR NAS DOEN\u00c7AS OSTEOARTICULARES E AUTOIMNUNES: EM MODELOS PR\u00c9-CL\u00cdNICOS E TERAP\u00caUTICOS
    \nPROJETO WALCY TEODORO:<\/strong> ESTUDOS SOBRE O PAPEL DO COL\u00c1GENO DO TIPO V NOS MECANISMOS DE REGENERA\u00c7\u00c3O E FIBR\u00d3TICOS<\/p>\n

    \u00a0<\/strong><\/h2>\n

    <\/p>","protected":false},"excerpt":{"rendered":"

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