{"id":653,"date":"2020-05-22T11:03:45","date_gmt":"2020-05-22T14:03:45","guid":{"rendered":"http:\/\/www.musculoesqueleticousp.com.br\/?page_id=653"},"modified":"2024-08-19T20:11:38","modified_gmt":"2024-08-19T23:11:38","slug":"eloisa-silva-dutra-de-oliveira-bonfa","status":"publish","type":"page","link":"https:\/\/www.musculoesqueleticousp.com.br\/es\/pesquisas\/orientadores\/eloisa-silva-dutra-de-oliveira-bonfa\/","title":{"rendered":"Eloisa Silva Dutra de Oliveira Bonf\u00e1"},"content":{"rendered":"

\"\"<\/strong><\/p>\n

T\u00edtulo:<\/strong>\u00a0Professora Titular
\nE-mail:\u00a0<\/strong>eloisa.bonfa@hc.fm.usp.br<\/a>
\nLattes:\u00a0<\/strong>http:\/\/lattes.cnpq.br\/1810614032141202<\/a>
\nBolsa produtividade CNPq<\/strong>: PQ 1A
\nOrcid<\/strong>: ID 0000-0002-0520-4681 – https:\/\/orcid.org\/0000-0002-0520-4681<\/a>
\nScopus<\/strong>: ID 7004486222 –\u00a0 https:\/\/www.scopus.com\/authid\/detail.uri?authorId=7004486222<\/a>
\nGoogle scholar<\/strong>: ID wGAjdvkAAAAJ – https:\/\/scholar.google.com.br\/citations?user=wGAjdvkAAAAJ&hl=pt-BR&oi=ao<\/a>
\nResearch ID<\/strong>: \u00a0B-8438-2012 – https:\/\/publons.com\/researcher\/1495907\/eloisa-bonfa\/<\/a><\/p>\n

\u00a0<\/strong><\/p>\n

Linha de Pesquisa<\/h2>\n

Doen\u00e7as Reumatol\u00f3gicas Autoimunes,\u00a0com \u00eanfase no L\u00fapus Eritematoso Sist\u00eamico, vacinas, autoanticorpose\u00a0terapia\u00a0biol\u00f3gica em Doen\u00e7as Reumatol\u00f3gicas Autoimunes.<\/p>\n

Resumo<\/h2>\n

As principais linhas de pesquisa s\u00e3o aspectos cl\u00ednicos, laboratoriais e imunol\u00f3gicos das Doen\u00e7as Reumatol\u00f3gicas Autoimunes, particularmente o L\u00fapus Eritematoso Sist\u00eamico. Possui relevante contribui\u00e7\u00e3o no campo dos autoanticorpos, com especial destaque a descri\u00e7\u00e3o e caracteriza\u00e7\u00e3o dos anticorpos anti-riboss\u00f4micos P al\u00e9m da sua associa\u00e7\u00e3o com as manifesta\u00e7\u00f5es psiqui\u00e1tricas do L\u00fapus. Destaca-se tamb\u00e9m pela identificar pela primeira vez o arritmog\u00eanico potencial de anticorpos Ro\/SSA purificados \u201cin vitro\u201d.\u00a0Tem\u00a0estudos\u00a0pioneiros\u00a0sobre imunogenicidade e seguran\u00e7a de vacinas em doen\u00e7as autoimunes, que\u00a0serviram de base para inclus\u00e3o desse grupo de pacientes no programa nacional de imuniza\u00e7\u00e3o.\u00a0Tem uma linha pesquisa s\u00f3lida em terapia Biol\u00f3gica em Doen\u00e7as Reumatol\u00f3gicas Autoimunes.<\/p>\n

Principais Publica\u00e7\u00f5es<\/h2>\n
    \n
  1. Bonfa E,<\/strong><\/b>Golombek SJ, Kaufman LD, Skelly S, Weissbach H, Brot N, Elkon KB. Association between lupus psychosis and anti-ribosomal P protein antibodies. N Engl J Med. 1987;317(5):265-71. doi: 10.1056\/NEJM198707303170503.<\/li>\n
  2. Pasoto SG, Franco AS, Silva CA,Bonfa E<\/strong><\/b>. Sicca syndrome\/Sj\u00f6gren\u2019s disease associated with cancer immunotherapy: a\u00a0narrative review on clinical presentation, biomarkers, and management. Expert Rev Clin Immunol. 2024 Jun 25:1-19. doi: 10.1080\/1744666X.2024.2370327.<\/li>\n
  3. Medeiros-Ribeiro AC, Aikawa NE, Saad CGS, Yuki EFN, Pedrosa T, Fusco SRG, Rojo PT, Pereira RMR, Shinjo SK, Andrade\u00a0DCO, Sampaio-Barros PD, Ribeiro CT, Deveza GBH, Martins VAO, Silva CA, Lopes MH, Duarte AJS, Antonangelo L, Sabino EC,\u00a0Kallas EG, Pasoto SG,Bonfa E<\/strong><\/b>. Immunogenicity and safety of the CoronaVac inactivated vaccine in patients with\u00a0autoimmune rheumatic diseases: a phase 4 trial. Nat Med. 2021 Oct;27(10):1744-1751. doi: 10.1038\/s41591-021-01469-5.<\/li>\n
  4. Aikawa NE, Kupa LVK, Medeiros-Ribeiro AC, Saad CGS, Yuki EFN, Pasoto SG, Rojo PT, Pereira RMR, Shinjo SK, Sampaio-\u00a0Barros PD, Andrade DCO, Halpern ASR, Fuller R, Souza FHC, Guedes LKN, Assad APL, Moraes JCB, Lopes MRU, Martins VAO,\u00a0Betancourt L, Ribeiro CT, Sales LP, Bertoglio IM, Bonoldi VLN, Mello RLP, Balbi GGM, Sartori AMC, Antonangelo L, Silva CA,\u00a0Bonfa E<\/strong><\/b>. Increment of immunogenicity\u00a0after third\u00a0dose of a homologous inactivated SARS-CoV-2 vaccine in a large\u00a0population of patients with autoimmune rheumatic diseases. Ann Rheum Dis. 2022 Jul;81(7):1036-1043. doi: 10.1136\/annrheumdis-2021-222096<\/li>\n
  5. Aikawa NE, Kupa LVK, Pasoto SG, Medeiros-Ribeiro AC, Yuki EFN, Saad CGS, Pedrosa T, Fuller R, Shinjo SK, Sampaio-Barros\u00a0PD, Andrade DCO, Pereira RMR, Seguro LPC, Valim JML, Waridel F, Sartori AMC, Duarte AJS, Antonangelo L, Sabino EC,\u00a0Menezes PR, Kallas EG, Silva CA,Bonfa E<\/strong><\/b>. Immunogenicity and safety of two doses of the CoronaVac SARS-CoV-2 vaccine\u00a0in SARS-CoV-2 seropositive and seronegative patients with autoimmune rheumatic diseases in Brazil: a subgroup analysis of\u00a0a phase 4 prospective study. Lancet Rheumatol. 2022 Feb;4(2):e113-e124. doi: 10.1016\/S2665-9913(21)00327-1.<\/li>\n<\/ol>\n

     <\/p>\n

    PROJETOS ORIENTADOR\/ LINHA<\/strong><\/h2>\n

    Linha 6. SISTEMA IMUNE E AUTOIMUNE
    \n<\/strong>PROJETO ELOISA BONFA:<\/strong> ETIOPATOGENESE, DIAGN\u00d3STICO, TRATAMENTO E PREVEN\u00c7\u00c3O DE DOEN\u00c7AS AUTOIMUNES<\/p>","protected":false},"excerpt":{"rendered":"

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