{"id":29,"date":"2020-03-25T15:17:34","date_gmt":"2020-03-25T18:17:34","guid":{"rendered":"http:\/\/www.musculoesqueleticousp.com.br\/pesquisas\/disciplinas\/"},"modified":"2023-07-25T11:37:32","modified_gmt":"2023-07-25T14:37:32","slug":"disciplinas","status":"publish","type":"page","link":"https:\/\/www.musculoesqueleticousp.com.br\/es\/pesquisas\/disciplinas\/","title":{"rendered":"Disciplinas"},"content":{"rendered":"
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<\/i><\/i>MOT5726 – DISCIPLINA DE PESQUISA EXPERIMENTAL E TERAPIAS BIOL\u00d3GICAS EM ORTOPEDIA<\/div>\n
Sigla: MOT5726 – 8
\nNome: Disciplina de Pesquisa Experimental e Terapias Biol\u00f3gicas em Ortopedia
\n\u00c1rea: Ci\u00eancias do Sistema Musculoesquel\u00e9tico (5140)Datas de aprova\u00e7\u00e3o:
\nCCP: 18\/11\/2021
\nCPG: 20\/01\/2022
\nCoPGr:
\nData de ativa\u00e7\u00e3o: 20\/01\/2022
\nData de desativa\u00e7\u00e3o:Carga hor\u00e1ria:
\nTotal: 60 h
\nTe\u00f3rica:4 h
\nPr\u00e1tica:9 h
\nEstudo:2 h
\nCr\u00e9ditos:4
\nDura\u00e7\u00e3o:4 SemanasRespons\u00e1veis:
\n2065897 – Roberto Guarniero – 20\/01\/2022 at\u00e9 data atual
\n2963307 – Tiago Lazzaretti Fernandes – 20\/01\/2022 at\u00e9 data atual
\n3734237 – Marco Kawamura Demange – 20\/01\/2022 at\u00e9 data atualObjetivos:
\nProporcionar aos alunos de P\u00f3s-Gradua\u00e7\u00e3o informa\u00e7\u00f5es e meios para aprimorar conceitos que possibilitem desenvolver projetos de pesquisa que envolvam animais e humanos tanto do ponto de vista t\u00e9cnico, bio\u00e9tico, como na sele\u00e7\u00e3o mais adequada para cada projeto, principalmente com enfoque em terapias biol\u00f3gicas relacionadas ao tratamento de patologias musculoesquel\u00e9ticasJustificativa:
\nNecessidade de aprimorar o conhecimento b\u00e1sico e t\u00e9cnico para capacitar o aluno a desenvolver projetos com terapias biol\u00f3gicas e pesquisas experimentais em animais e humanos. H\u00e1 atualmente um grande crescimento no uso de terapias biol\u00f3gicas no tratamento de patologias do aparelho locomotor. Desta maneira, se faz importante o aprimoramento no conhecimento nas diversas \u00e1reas de pesquisa e terapia biol\u00f3gicas relacionadas a ortopedia (manipula\u00e7\u00e3o tecidual, cultivo celular, c\u00e9lulas tronco, citocinas e scaffolds). As pesquisas com terapia biol\u00f3gica no aparelho locomotor demandam adequado conhecimento de modelos experimentais.Conte\u00fado:
\nModelos experimentais; Comiss\u00e3o de \u00e9tica: Principais considera\u00e7\u00f5es; Modelos animais de artrose, les\u00e3o condral e consolida\u00e7\u00e3o \u00f3ssea; Experimenta\u00e7\u00e3o animal: hist\u00f3rico e implica\u00e7\u00f5es \u00e9ticas; Protocolos de pesquisa; Anestesia em animais e Eutan\u00e1sia; Anatomia Patol\u00f3gica; Manipula\u00e7\u00e3o tecidual sem cultivo celular; Plasma rico em plaquetas; Citocinas (Fatores de Crescimento e BMPs); C\u00e9lulas Tronco e C\u00e9lulas Pluripotentes; Cultivo Celular (osteoblastos, fibroblastos, queratin\u00f3citos e condr\u00f3citos); Princ\u00edpios de Boas Pr\u00e1ticas em Cultivo Celular (GMP); Estudos translacionais e ensaios cl\u00ednicos fase I\/II e fase III multic\u00eantricos; Regulamenta\u00e7\u00f5es de uso de terapias biol\u00f3gicas avan\u00e7adas em humanos.
\nForma de avalia\u00e7\u00e3o:
\nA participa\u00e7\u00e3o dos alunos ser\u00e1 avaliada a partir da frequ\u00eancia nas atividades virtuais on-line s\u00edncronas (aulas e discuss\u00f5es de artigos, 30%), assim como a contagem de posts v\u00e1lidos e intera\u00e7\u00f5es ass\u00edncronas off-line durante a atividade semanal em grupo (70%). Alunos com menos de 70% de participa\u00e7\u00e3o nas atividades s\u00edncronas ser\u00e3o reprovados.Observac\u00e3o:
\nN\u00ba. m\u00ednimo de alunos= 4 alunos; N\u00ba. m\u00e1ximo de alunos= 30.Tipo de oferecimento da disciplna: N\u00e3o-PresencialInforma\u00e7\u00f5es adicionais do oferecimento da disciplina:
\nA porcentagem da disciplina que ocorrer\u00e1 no sistema n\u00e3o presencial (1- 100%).
\nA disciplina ser\u00e1 oferecida 100% n\u00e3o presencialDetalhamento das atividades que ser\u00e3o presenciais e das que ser\u00e3o desenvolvidas via remota, com discrimina\u00e7\u00e3o do tempo de atividade cont\u00ednua online.Conforme mencionado anteriormente, todas as atividades ser\u00e3o realizadas de forma n\u00e3o presencial, incluindo as aulas expositivas, apresenta\u00e7\u00e3o de artigos, discuss\u00e3o dos alunos nos f\u00f3runs e processo de avalia\u00e7\u00e3o.As aulas online ter\u00e3o dura\u00e7\u00e3o de 1 hora a cada semana e as atividades de discuss\u00e3o de artigos e f\u00f3runs online ter\u00e3o a dura\u00e7\u00e3o de 2 horas a cada semana, totalizando 4 semanas de programa.Especifica\u00e7\u00e3o se as aulas, quando online, ser\u00e3o s\u00edncronas ou ass\u00edncronas.
\nAs aulas ministradas ser\u00e3o s\u00edncronas e as atividades do f\u00f3rum de discuss\u00e3o ser\u00e3o ass\u00edncronas.Descri\u00e7\u00e3o do tipo de material e\/ou conte\u00fado que ser\u00e1 disponibilizado para o aluno e a plataforma que ser\u00e1 utilizada.A plataforma a ser utilizada e disponibilizada para os alunos ser\u00e1 o Google classroom e para as atividades s\u00edncronas o Google Meets. A cada semana, novos \u201cassingments\u201d como artigos cient\u00edficos e materiais para estudos ser\u00e3o disponibilizados na plataforma Google classroom para discuss\u00e3o ass\u00edncrona.Defini\u00e7\u00e3o sobre a presen\u00e7a na Universidade e, quando necess\u00e1ria, discriminar quem dever\u00e1 estar presente (professora\/professor; aluna\/aluno; ambos).
\nComo informado anteriormente, n\u00e3o est\u00e1 prevista a participa\u00e7\u00e3o presencial obrigat\u00f3ria nessa disciplina oferecida, tanto para professores quanto para alunos.Descri\u00e7\u00e3o dos tipos e da frequ\u00eancia de intera\u00e7\u00e3o entre aluna\/aluno e professora\/professor (somente durante as aulas; fora do per\u00edodo das aulas; hor\u00e1rios; por chat\/e-mail\/f\u00f3runs ou outro).As intera\u00e7\u00f5es e frequ\u00eancias ser\u00e3o contabilizadas pelos professores durante a atividade s\u00edncrona online da aula (lista de presen\u00e7a no chat do Google Meets a ser disponibilizado na metade da aula) e tamb\u00e9m a partir da contabiliza\u00e7\u00e3o dos posts v\u00e1lidos de coment\u00e1rios dos alunos nos f\u00f3runs de discuss\u00e3o ass\u00edncronos durante a semana.Bibliografia:
\nExperimentos com Animais \/ Animal experiments:<\/p>\n
    \n
  • Cohen, B. J. 1958. The evolution of animal medicine in the USA. J. Am. Vet. Med. Assoc. 135: 161-164.<\/li>\n
  • Lane- Petter, W., Pearson, A.E.G. 1971. The Laboratory Animal Principles and practice. Academic Press. London, New York.<\/li>\n
  • Hime J.M., O’ Donoghue P.N. (eds.) 1979. Handbook of Diseases of Laboratory Animals. Heinemann Veterinary Books, London.<\/li>\n
  • Canadian Council on Animal Care. 1980, 1984. Guide to the care and use of Experimental Animals. Vol.1 and 2.<\/li>\n
  • Harkness J.E., Wagner, J.E. 1983. The niology and Medicine of Rabbits and Rodents. 1983. Lea & Febiger, Philadelphia.<\/li>\n
  • Animal Welfare Act. U.S. Department of Agriculture (USDA). Http:\/\/aphis.usda.gov\/animal_welfare<\/li>\n<\/ul>\n

    Modelos Experimentais em Animais \/ Experimental Models in Animals:<\/strong><\/p>\n

      \n
    • Caplan AI, Elyaderani M, Mochizuki Y, Wakitani S, Goldberg VM. Principles of cartilage repair and regeneration. Clin Orthop Relat Res 1997:254-69.<\/li>\n
    • Grande DA, Pitman MI, Peterson L, Menche D, Klein M. The repair of experimentally produced defects in rabbit articular cartilage by autologous chondrocyte transplantation. Journal of orthopaedic research: official publication of the Orthopaedic Research Society 1989;7:208-18.<\/li>\n
    • Murphy JM, Fink DJ, Hunziker EB, Barry FP. Stem cell therapy in a caprine model of osteoarthritis. Arthritis and rheumatism 2003;48:3464-74.<\/li>\n
    • Yamamoto T, Wakitani S, Imoto K, et al. Fibroblast growth factor-2 promotes the repair of partial thickness defects of articular cartilage in immature rabbits but not in mature rabbits. Osteoarthritis Cartilage 2004;12:636-41.<\/li>\n
    • Swart E, Konopka G, Gardner TR, O J, Greisberg J. A rat model of chondrocyte death after closed intra-articular fracture. J Orthop Trauma 2013;27:e50-6.<\/li>\n
    • Khatab S, van Osch GJ, Kops N, Bastiaansen-Jenniskens YM, Bos PK, Verhaar JA, Bernsen MR, van Buul GM. Mesenchymal stem cell secretome reduces pain and
      \nprevents cartilage damage in a murine osteoarthritis model. Eur Cell Mater. 2018
      \nNov 6;36:218-230.<\/li>\n
    • Fernandes TL, Shimomura K, Asperti A, et al (2018) Development of a Novel Large Animal Model to Evaluate Human Dental Pulp Stem Cells for Articular Cartilage Treatment. Stem Cell Rev Rep. 2018 Oct;14(5): 734-743.<\/li>\n
    • Chouhan DK, Dhillon MS, Patel S, Bansal T, Bhatia A, Kanwat H. Multiple Platelet-Rich Plasma Injections Versus Single Platelet-Rich Plasma Injection in Early Osteoarthritis of the Knee: An Experimental Study in a Guinea Pig Model of Early Knee Osteoarthritis. Am J Sports Med. 2019 Aug;47(10):2300-2307.<\/li>\n<\/ul>\n

      C\u00e9lulas Tronco e C\u00e9lulas Pluripotentes \/ Stem Cells and Pluripotent Cells:<\/strong><\/p>\n

        \n
      • Wakitani S, Goto T, Pineda SJ, et al. Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Joint Surg Am 1994;76:579-92.<\/li>\n
      • Wakitani S, Imoto K, Yamamoto T, Saito M, Murata N, Yoneda M. Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage 2002;10:199-206.<\/li>\n
      • Caplan AI. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Journal of cellular physiology 2007;213:341-7.<\/li>\n
      • Kon E, Filardo G, Roffi A, Andriolo L, Marcacci M. New trends for knee cartilage regeneration: from cell-free scaffolds to mesenchymal stem cells. Current reviews in musculoskeletal medicine 2012;5:236-43.<\/li>\n
      • Caplan AI. Adult mesenchymal stem cells and the NO pathways. Proceedings of the National Academy of Sciences of the United States of America 2013;110:2695-6.<\/li>\n
      • Demange MK, Sisto M, Rodeo S. Future trends for unicompartmental arthritis of the knee: injectables & stem cells. Clinics in sports medicine 2014;33:161-74.<\/li>\n
      • Fahy N, de Vries-van Melle ML, Lehmann J, Wei W, Grotenhuis N, Farrell E, van der Kraan PM, Murphy JM, Bastiaansen-Jenniskens YM, van Osch GJVM (2014) Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state. Osteoarthr Cartil 22:1167\u20131175.<\/li>\n
      • Ankrum JA, Ong JF, Karp JM (2014) Mesenchymal stem cells: Immune evasive, not immune privileged. Nat Biotechnol 32:252\u2013260.<\/li>\n
      • Chahla, J, Piuzzi, NS, Mitchell, JJ, Dean, CS, Pascual-Garrido,C, LaPrade, RF, Muschler, GF: Intra-Articular Cellular Therapy for Osteoarthritis and Focal Cartilage Defects of the Knee: A Systematic Review of the Literature and Study Quality Analysis, 2016 J Bone Joint 98:18 , p 1511-21. PMID: 27655978.<\/li>\n
      • Caplan, Arnold I. 2017. \u201cMesenchymal Stem Cells: Time to Change the Name!\u201d Stem Cells Translational Medicine 6 (6): 1445\u201351.<\/li>\n
      • Caplan, Arnold I. 2017. \u201cNew MSC: MSCs as Pericytes Are Sentinels and Gatekeepers.\u201d Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society 35 (6): 1151\u201359.<\/li>\n
      • Park Y-B, Ha C-W, Lee C-H, Yoon YC, Park Y-G (2017) Cartilage Regeneration in Osteoarthritic Patients by a Composite of Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cells and Hyaluronate Hydrogel: Results from a Clinical Trial for Safety and Proof-of-Concept with 7 Years of Extended Follow-Up. Stem Cells Transl Med 6:613\u2013621.<\/li>\n
      • Cotter, E. J., Wang, K. C., Yanke, A. B., & Chubinskaya, S. (2018). Bone Marrow Aspirate Concentrate for Cartilage Defects of the Knee: From Bench to Bedside Evidence. Cartilage, 9(2), 161\u2013170.<\/li>\n
      • Li, Xu, Mingjie Wang, Xiaoguang Jing, Weimin Guo, Chunxiang Hao, Yu Zhang, Shuang Gao, et al. 2018. \u201cBone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells: Characterization, Differentiation, and Applications in Cartilage Tissue Engineering.\u201d Critical Reviews in Eukaryotic Gene Expression 28 (4): 285\u2013310.<\/li>\n
      • Sivasubramaniyan, Kavitha, Dragos C. Ilas, Abhishek Harichandan, Pieter K. Bos, Diego L. Santos, Peter de Zwart, Wendy J. L. M. Koevoet, et al. 2018. \u201cBone Marrow-Harvesting Technique Influences Functional Heterogeneity of Mesenchymal Stem\/Stromal Cells and Cartilage Regeneration.\u201d The American Journal of Sports Medicine 46 (14): 3521\u201331.<\/li>\n
      • Olivos-Meza A, P\u00e9rez Jim\u00e9nez FJ, Granados-Montiel J, Landa-Sol\u00eds C, Cort\u00e9s Gonz\u00e1lez S, Jim\u00e9nez Aroche CA, Valdez Ch\u00e1vez M, Ren\u00e1n Le\u00f3n S, Gomez-Garcia R, Mart\u00ednez-L\u00f3pez V, Ortega-S\u00e1nchez C, Parra-Cid C, Velasquillo Martinez C, Ibarra C. First Clinical Application of Polyurethane Meniscal Scaffolds with Mesenchymal Stem Cells and Assessment of Cartilage Quality with T2 Mapping at 12 Months. Cartilage. 2021 Dec;13(1_suppl):197S-207S.<\/li>\n
      • Zellner J, Johnstone B, Barry F, Madry H. Mesenchymal Stem Cell Based Regenerative Treatment of the Knee: From Basic Science to Clinics. Stem Cells Int. 2019 Sep 9;2019:7608718.<\/li>\n
      • Shariatzadeh M, Song J, Wilson SL. The efficacy of different sources of mesenchymal stem cells for the treatment of knee osteoarthritis. Cell Tissue Res. 2019 Dec;378(3):399-410.<\/li>\n
      • Muhammad SA, Nordin N, Mehat MZ, Fakurazi S (2019) Comparative efficacy of stem cells and secretome in articular cartilage regeneration: a systematic review and meta-analysis. Cell Tissue Res 375:329\u2013344<\/li>\n<\/ul>\n

        Cultivo Celular \/ Cell Culture:<\/strong><\/p>\n

          \n
        • Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. The New England journal of medicine 1994;331:889-95.<\/li>\n
        • Somoza RA, Welter JF, Correa D, Caplan AI. Chondrogenic differentiation of mesenchymal stem cells: challenges and unfulfilled expectations. Tissue Eng Part B Rev. 2014 Dec;20(6):596-608.<\/li>\n
        • Robinson PG, Murray IR, West CC, Goudie EB, Yong LY, White TO, LaPrade RF. Reporting of Mesenchymal Stem Cell Preparation Protocols and Composition: A Systematic Review of the Clinical Orthopaedic Literature. Am J Sports Med. 2019 Mar;47(4):991-1000.<\/li>\n
        • Fernandes TL, Kimura HA, Pinheiro CCG, Shimomura K, Nakamura N, Ferreira JR, Gomoll AH, Hernandez AJ, Bueno DF (2018) Human Synovial Mesenchymal Stem Cells Good Manufacturing Practices for Articular Cartilage Regeneration. Tissue Eng Part C Methods 24:709\u2013716.<\/li>\n
        • Moreno-Manzano, Victoria, and Elisa Oltra Garc\u00eda. 2019. \u201cCulturing Adult Stem Cells for Cell-Based Therapeutics: Neuroimmune Applications.\u201d Cell Culture. https:\/\/doi.org\/10.5772\/intechopen.80714.<\/li>\n
        • Ha, Chul-Won, Yong-Beom Park, Seong Hwan Kim, and Han-Jun Lee. 2019. \u201cIntra-Articular Mesenchymal Stem Cells in Osteoarthritis of the Knee: A Systematic Review of Clinical Outcomes and Evidence of Cartilage Repair.\u201d Arthroscopy: The Journal of Arthroscopic & Related Surgery: Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association 35 (1): 277\u201388.e2.<\/li>\n
        • Ebert JR, Fallon M, Ackland TR, Janes GC, Wood DJ. Minimum 10-Year Clinical and Radiological Outcomes of a Randomized Controlled Trial Evaluating 2 Different Approaches to Full Weightbearing After Matrix-Induced Autologous Chondrocyte Implantation. Am J Sports Med. 2020 Jan;48(1):133-142.<\/li>\n
        • Everhart JS, Jiang EX, Poland SG, Du A, Flanigan DC. Failures, Reoperations, and Improvement in Knee Symptoms Following Matrix-Assisted Autologous Chondrocyte Transplantation: A Meta-Analysis of Prospective Comparative Trials. Cartilage. 2021 Dec;13(1_suppl):1022S-1035S.<\/li>\n
        • Fernandes TL, Cortez de SantAnna JP, Frisene I, Gazarini JP, Gomes Pinheiro CC, Gomoll AH, Lattermann C, Hernandez AJ, Franco Bueno D. Systematic Review of Human Dental Pulp Stem Cells for Cartilage Regeneration. Tissue Eng Part B Rev. 2020 Feb;26(1):1-12.<\/li>\n
        • Brindo da Cruz IC, Velosa APP, Carrasco S, Dos Santos Filho A, Tomaz de Miranda J, Pompeu E, Fernandes TL, Bueno DF, Fanelli C, Goldenstein-Schainberg C, Fabro AT, Fuller R, Silva PL, Capelozzi VL, Teodoro WR. Post-Adipose-Derived Stem Cells (ADSC) Stimulated by Collagen Type V (Col V) Mitigate the Progression of Osteoarthritic Rabbit Articular Cartilage. Front Cell Dev Biol. 2021 Mar 22;9:606890.<\/li>\n<\/ul>\n

          Citocinas, PRP, Secretomas e Imuno-regula\u00e7\u00e3o \/ Cytokines, PRP, Secretomes and Immunerregulation:<\/strong><\/p>\n

            \n
          • de Almeida AM, Demange MK, Sobrado MF, Rodrigues MB, Pedrinelli A, Hernandez AJ. Patellar tendon healing with platelet-rich plasma: a prospective randomized controlled trial. The American journal of sports medicine 2012;40:1282-8.<\/li>\n
          • Demange MK, de Almeida AM, Rodeo SA. Updates in biological therapies for knee injuries: tendons. Current reviews in musculoskeletal medicine 2014;7:239-46.<\/li>\n
          • Pot, Michiel W., Toin H. van Kuppevelt, Veronica K. Gonzales, Pieter Buma, Joanna IntHout, Rob B. M. de Vries, and Willeke F. Daamen. 2017. \u201cAugmented Cartilage Regeneration by Implantation of Cellular versus Acellular Implants after Bone Marrow Stimulation: A Systematic Review and Meta-Analysis of Animal Studies.\u201d PeerJ 5 (October): e3927.<\/li>\n
          • Seong W, Chai R, Hoi J, Hui P, Kiang S (2017) Seminars in Cell & Developmental Biology MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment. Semin Cell Dev Biol 67:56\u201364.<\/li>\n
          • Anitua, Eduardo, Ram\u00f3n Cugat, and Mikel S\u00e1nchez. 2018. Platelet Rich Plasma in Orthopaedics and Sports Medicine. Springer.<\/li>\n
          • Khatab S, van Osch GJ, Kops N, Bastiaansen-Jenniskens YM, Bos PK, Verhaar JA, Bernsen MR, van Buul GM. Mesenchymal stem cell secretome reduces pain and prevents cartilage damage in a murine osteoarthritis model. Eur Cell Mater. 2018 Nov 6;36:218-230.<\/li>\n
          • Yokota, Naomasa, Mari Hattori, Tadahiko Ohtsuru, Masaki Otsuji, Stephen Lyman, Kazunori Shimomura, and Norimasa Nakamura. 2019. \u201cComparative Clinical Outcomes After Intra-Articular Injection With Adipose-Derived Cultured Stem Cells or Noncultured Stromal Vascular Fraction for the Treatment of Knee Osteoarthritis.\u201d The American Journal of Sports Medicine 47 (11): 2577\u201383.<\/li>\n
          • Oudelaar, Bart W., Joost C. Peerbooms, Rianne Huis In \u2019t Veld, and Anne J. H. Vochteloo. 2019. \u201cConcentrations of Blood Components in Commercial Platelet-Rich Plasma Separation Systems: A Review of the Literature.\u201d The American Journal of Sports Medicine 47 (2): 479\u201387.<\/li>\n
          • Chen, Pu, Liuwei Huang, Yufeng Ma, Dong Zhang, Xiaozhe Zhang, Jun Zhou, Anmin Ruan, and Qingfu Wang. 2019. \u201cIntra-Articular Platelet-Rich Plasma Injection for Knee Osteoarthritis: A Summary of Meta-Analyses.\u201d Journal of Orthopaedic Surgery and Research 14 (1): 385.<\/li>\n
          • Ha, Chul-Won, Yong-Beom Park, Jae Won Jang, Manyoung Kim, Jin-A Kim, and Yong-Geun Park. 2019. \u201cVariability of the Composition of Growth Factors and Cytokines in Platelet-Rich Plasma From the Knee With Osteoarthritis.\u201d Arthroscopy: The Journal of Arthroscopic & Related Surgery: Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association 35 (10): 2878\u201384.e1.<\/li>\n
          • Southworth TM, Naveen NB, Tauro TM, Leong NL, Cole BJ. The Use of Platelet-Rich Plasma in Symptomatic Knee Osteoarthritis. J Knee Surg. 2019 Jan;32(1):37-45.<\/li>\n
          • Fernandes TL, Gomoll AH, Lattermann C, Hernandez AJ, Bueno DF, Amano MT.
            \nMacrophage: A Potential Target on Cartilage Regeneration. Front Immunol. 2020
            \nFeb 11;11:111.<\/li>\n<\/ul>\n

            Recomenda\u00e7\u00f5es e Regulamenta\u00e7\u00e3o Terapia Celular Avan\u00e7ada em Humanos \/ Advanced Cell Therapy Regulation:<\/strong><\/p>\n

              \n
            • RDC n\u00ba 504\/2021 que disp\u00f5e sobre regulamento sanit\u00e1rio para o transporte de material biol\u00f3gico humano (anterior RDC 20\/2014).<\/li>\n
            • Chu CR, Rodeo S, Bhutani N, et al (2019) Optimizing Clinical Use of Biologics in Orthopaedic Surgery: Consensus Recommendations From the 2018 AAOS\/NIH U-13 Conference. J Am Acad Orthop Surg 27:e50\u2013e63<\/li>\n
            • RDC n\u00ba 505\/2021; disp\u00f5e sobre o registro de produto de terapia avan\u00e7ada e d\u00e1 outras provid\u00eancias (anterior RDC 338\/2020)<\/li>\n
            • RDC n\u00ba 506\/2021: disp\u00f5e sobre as regras para a realiza\u00e7\u00e3o de ensaios cl\u00ednicos com produto de terapia avan\u00e7ada investigacional no Brasil, e d\u00e1 outras provid\u00eancias (anterior RDC 260\/18).<\/li>\n
            • RDC n\u00ba 508\/2021: disp\u00f5e sobre as Boas Pr\u00e1ticas em C\u00e9lulas Humanas para Uso Terap\u00eautico e pesquisa cl\u00ednica, e d\u00e1 outras provid\u00eancias (anterior RDC 214\/18)
              \nhttps:\/\/www.in.gov.br\/en\/web\/dou\/-\/resolucao-rdc-n-505-de-27-de-maio-de-2021-323002775<\/li>\n
            • https:\/\/www.gov.br\/anvisa\/pt-br\/assuntos\/noticias-anvisa\/2021\/anvisa-avanca-na-consolidacao-de-suas-normas<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
              \n
              <\/i><\/i>MOT5734 – MODELOS PARA AN\u00c1LISE DE LES\u00d5ES DO SISTEMA NERVOSO<\/div>\n
              \n

              Sigla: MOT5734 \u2013 6
              \nNome: Modelos para An\u00e1lise de Les\u00f5es do Sistema Nervoso
              \n\u00c1rea: Ci\u00eancias do Sistema Musculoesquel\u00e9tico (5140)<\/p>\n

              Datas de aprova\u00e7\u00e3o:
              \nCCP: 27\/04\/2022
              \nCPG: 14\/07\/2022
              \nCoPGr:
              \nData de ativa\u00e7\u00e3o:14\/07\/2022
              \nData de desativa\u00e7\u00e3o:<\/p>\n

              Carga hor\u00e1ria:
              \nTotal: 45 h
              \nTe\u00f3rica: 0 h
              \nPr\u00e1tica: 12 h
              \nEstudo: 3 h
              \nCr\u00e9ditos: 3
              \nDura\u00e7\u00e3o: 3 Semanas<\/p>\n

              Respons\u00e1veis:
              \n96641 – Tarcisio Eloy Pessoa de Barros Filho – 14\/07\/2022 at\u00e9 data atual
              \n443791 – Alexandre Foga\u00e7a Cristante – 14\/07\/2022 at\u00e9 data atual
              \n1768878 – Raphael Martus Marcon – 14\/07\/2022 at\u00e9 data atual<\/p>\n

              Objetivos:<\/p>\n

              Baseado na mesma linha de pesquisa (Modelos Para Estudos de Les\u00f5es do Sistema Nervoso) esta disciplina objetiva fornecer bases te\u00f3ricas e pedag\u00f3gicas aos alunos que estejam desenvolvendo projetos de pesquisa relacionados a esta linha, com an\u00e1lise cr\u00edtica dos trabalhos apresentados em rela\u00e7\u00e3o a metodologia empregada; Fatores de inclus\u00e3o e exclus\u00e3o; Atualidade do trabalho; Literatura pertinente; se as conclus\u00f5es s\u00e3o compat\u00edveis com a proposi\u00e7\u00e3o do trabalho; An\u00e1lise cr\u00edtica do conte\u00fado.<\/p>\n

              Justificativa:
              \nVisa instituir um grupo de estudos entre orientadores e alunos que estejam desenvolvendo projetos com a mesma linha de interesse e discutindo os trabalhos de maior impacto dentro do PubMed.<\/p>\n

              Conte\u00fado:
              \nApresenta\u00e7\u00e3o de semin\u00e1rio e discuss\u00e3o de projetos de pesquisa e dos trabalhos publicados nos \u00faltimos 5 anos sobre les\u00f5es traum\u00e1ticas e degenerativas da coluna vertebral com \u00eanfase para trabalhos experimentais e histopatol\u00f3gicos<\/p>\n

              Forma de Avalia\u00e7\u00e3o:
              \nParticipa\u00e7\u00e3o ativa nas discuss\u00f5es durante as apresenta\u00e7\u00f5es dos semin\u00e1rios;
              \nApresenta\u00e7\u00e3o dos semin\u00e1rios;
              \n85% de frequ\u00eancia nas aulas.<\/p>\n

              Observa\u00e7\u00e3o:
              \nAs disciplinas ser\u00e3o ministradas as 2as, 3as e 5as. feiras das 8 \u00e0s 12h.
              \nNo. m\u00ednimo de alunos= 3 alunos; No. m\u00e1ximo de alunos=20<\/p>\n

              Bibliografia<\/p>\n

                \n
              • Tarlov IM, Klinger H, Vitale S. Spinal cord compression studies. I. Experimental techniques to produce acute and gradual compression. Arch Neurol Psychiat. 1953;70:813-9.<\/li>\n
              • Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma. 1995;12(1):1-21.<\/li>\n
              • McDonald JW. Repairing the damaged spinal cord. Sci Am. 1999;281(3):64-73.<\/li>\n
              • Rodrigues NR. Padroniza\u00e7\u00e3o da les\u00e3o medular espinal em ratos Wistar [tese]. S\u00e3o Paulo: Faculdade de Medicina, Universidade de S\u00e3o Paulo; 1999.<\/li>\n
              • Tator CH. Review of treatment trials in human spinal cord injury issues, difficulties, and recommendations. Neurosurgery. 2006;59(5):957-82.<\/li>\n
              • McDonald JW, Becker D. Spinal cord injury: promising interventions and realistic goals. Am J Phys Med Rehabil. 2003;82(10 Suppl):S38-49.<\/li>\n
              • McDonald JW, Howard MJ. Repairing the damaged spinal cord: a summary of our early success with embryonic stem cell transplantation and remyelination. Prog Brain Res. 2002;137:299-309.<\/li>\n
              • Santos GB, Cristante AF, Marcon RM, Souza FI, Barros Filho TEP, Damasceno ML. Modelo experimental de les\u00e3o medular e protocolo de avalia\u00e7\u00e3o motora em ratos wistar. Acta Ortop Bras. 2011;19(2):87-91.<\/li>\n
              • Cristante AF, Damasceno ML, Barros Filho TEP, de Oliveira RP, Marcon RM, da Rocha ID. Evaluation of the effects of hyperbaric oxygen therapy for spinal cord lesion in correlation with the moment of intervention. Spinal Cord. 2012; 50(7):502\u20136.<\/li>\n
              • Letaif OB, Cristante AF, Barros-Filho TEP, Ferreira R, Santos GB, Rocha ID, Marcon RM. Effects of estrogen on functional and neurological recovery after spinal cord injury: An experimental study with rats CLINICS 2015;70(10):700-705.<\/li>\n
              • Borges PA, Cristante AF, Barros-Filho TEP, Natalino RJM, Santos GB, Marcon RM. Standardization of a spinal cord lesion model and neurologic evaluation using mice. CLINICS 2018;73:e293.<\/li>\n
              • Letaif OB, Tavares-Junior MCM*, Santos GB, RicardoJ.R.Ferreira, Marcon RM, Cristante AF, Barros-Filho TEP.0Standardization of an experimental model of intra- dural injection after spinal cord injury in rats. CLINICS 2021;76:e2740.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
                \n
                <\/i><\/i>MOT5742 – APLICA\u00c7\u00c3O DA METODOLOGIA CIENT\u00cdFICA NA PESQUISA DO APARELHO LOCOMOTOR<\/div>\n
                \n

                Sigla: MOT5742 – 3
                \nNome: Aplica\u00e7\u00e3o da Metodologia Cient\u00edfica na Pesquisa do Aparelho Locomotor
                \n\u00c1rea: Ci\u00eancias do Sistema Musculoesquel\u00e9tico (5140)<\/p>\n

                Datas de aprova\u00e7\u00e3o:
                \nCCP: 02\/08\/2019
                \nCPG: 19\/09\/2019
                \nCoPGr:
                \nData de ativa\u00e7\u00e3o:19\/09\/2019
                \nData de desativa\u00e7\u00e3o:<\/p>\n

                Carga hor\u00e1ria:
                \nTotal:120 h
                \nTe\u00f3rica:1 h
                \nPr\u00e1tica: 4 h
                \nEstudo: 3 h
                \nCr\u00e9ditos:8
                \nDura\u00e7\u00e3o:15 Semanas<\/p>\n

                Respons\u00e1veis:
                \n432902 – Eduardo Ferreira Borba Neto – 19\/09\/2019 at\u00e9 data atual
                \n1492245 – Marcelo Rosa de Rezende – 19\/09\/2019 at\u00e9 data atual
                \n1740533 – Rames Mattar Junior – 19\/09\/2019 at\u00e9 data atual
                \n3724222 – Camilo Partezani Helito – 19\/09\/2019 at\u00e9 data atual
                \n5093960 – Danieli Castro Oliveira de Andrade – 19\/09\/2019 at\u00e9 data atual<\/p>\n

                Objetivos:
                \nOferecer ao aluno da p\u00f3s-gradua\u00e7\u00e3o a oportunidade estudar a metodologia cient\u00edfica, e aplicar estes conceitos na pr\u00e1tica, com uma vis\u00e3o cr\u00edtica sobre os trabalhos cient\u00edficos, em especial na \u00e1rea do aparelho locomotor. Ser\u00e1 oferecida ao aluno a oportunidade de discutir seu projeto de pesquisa ao longo do curso.<\/p>\n

                Justificativa:
                \nA elabora\u00e7\u00e3o de trabalhos cient\u00edficos requer o conhecimento das regras metodol\u00f3gicas, que v\u00e3o dar credibilidade aos resultados obtidos. Para tal, \u00e9 necess\u00e1rio o conhecimento b\u00e1sico das normas que regem a elabora\u00e7\u00e3o de um trabalho cient\u00edfico. \u00c9 muito importante que os conhecimentos estudados possam ser colocados em pr\u00e1tica, atrav\u00e9s da discuss\u00e3o de trabalhos cient\u00edficos com uma vis\u00e3o cr\u00edtica, em especial do aspecto metodol\u00f3gico.<\/p>\n

                Conte\u00fado:
                \nO curso ter\u00e1 como escopo, o estudo conceitual da estrutura\u00e7\u00e3o metodol\u00f3gica de um trabalho cient\u00edfico, atrav\u00e9s de discuss\u00f5es de temas via on-line, aliado ao estudo pr\u00e1tico atrav\u00e9s da participa\u00e7\u00e3o ativa em reuni\u00f5es de trabalhos cient\u00edficos, em que poder\u00e1 colocar em pr\u00e1tica os conceitos te\u00f3ricos: Introdu\u00e7\u00e3o \u00e0 pesquisa cient\u00edfica. Formula\u00e7\u00e3o da pergunta cient\u00edfica. Estudo do tamanho da amostra (poder e erro). Escolha dos m\u00e9todos estat\u00edsticos. Regulariza\u00e7\u00e3o dos projetos junto \u00e0s comiss\u00f5es. Coleta e armazenamento de dados da maneira segura. Termo de consentimento. Ferramentas de pesquisa bibliogr\u00e1fica. Busca de recursos para o projeto. Aspectos \u00e9ticos do projeto. Estrat\u00e9gias para publica\u00e7\u00e3o. Ferramentas de avalia\u00e7\u00e3o de resultados no aparelho locomotor. Estudos com equipamentos.<\/p>\n

                CRIT\u00c9RIOS DE AVALIA\u00c7\u00c3O:
                \nParticipa\u00e7\u00e3o ativa nas discuss\u00f5es durante as apresenta\u00e7\u00f5es dos semin\u00e1rios. Apresenta\u00e7\u00e3o dos semin\u00e1rios. 85% de frequ\u00eancia nas aulas. Elabora\u00e7\u00e3o de relat\u00f3rio sobre a influ\u00eancia da disciplina no seu projeto.<\/p>\n

                OBSERVA\u00c7\u00d5ES:
                \nEsta disciplina ser\u00e1 ministrada atrav\u00e9s de:
                \n– Atividade on-line
                \n– Participa\u00e7\u00e3o nas reuni\u00f5es de trabalhos cient\u00edficos
                \nApresenta\u00e7\u00e3o de semin\u00e1rio
                \nAs aulas te\u00f3ricas e pr\u00e1ticas ser\u00e3o ministradas \u00e0s sextas feiras das 10 as 12h
                \nN\u00ba m\u00ednimo de alunos = 5; N\u00ba m\u00e1ximo de alunos = 15
                \nTipo de oferecimento da disciplina: Presencial<\/p>\n

                Bibliografia<\/p>\n

                  \n
                • Peto, V., Coulter, A. & Bond, A. Factors Affecting General Practitioners\u2019 Recruitment of Patients into a Prospective Study. Fam. Pract. 10, 207\u2013211 (1993).<\/li>\n
                • Petkova, E., Quitkin, F. M., McGrath, P. J., Stewart, J. W. & Klein, D. F. A method to quantify rater bias in antidepressant trials. Neuropsychopharmacology 22, 559\u201365 (2000).<\/li>\n
                • Grunfeld, E., Zitzelsberger, L., Coristine, M. & Aspelund, F. Barriers and facilitators to enrollment in cancer clinical trials: qualitative study of the perspectives of clinical research associates. Cancer 95, 1577\u201383 (2002).<\/li>\n
                • Elise Whitley, Jonathan Ball, Statistics review 3: Hypotheses testing and P values, Critical Care. 2002. 6:222-225 (18 March 2002)<\/li>\n
                • Elise Whitley, Jonathan Ball, Statistics review 5: Comparison of means, Critical Care 2002, 6:424-428 (12 July 2002)<\/li>\n
                • Elise Whitley, Jonathan Ball, Statistics review 6: Nonparametric methods, Critical Care 2002, 6:509-513 (13 September 2002)<\/li>\n
                • C\u00f3digo Civil Brasileiro C\u00f3digo Penal Brasileiro Conselho Federal de Medicina – C\u00f3digo de \u00c9tica M\u00e9dica Constitui\u00e7\u00e3o da Rep\u00fablica do Brasil Daniel Andler, Anne Fagot-Largeault e Bertrand – Saint-Sernin: Philosophie des Sciences I & II, Paris: Gallimard, 2002<\/li>\n
                • Tunis SR, Stryer DB, Clancy CM. Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy. JAMA. 2003 Sep 24;290(12):1624-32.<\/li>\n
                • Bridgman S, Engebretsen L, Dainty K, Kirkley A, Maffulli N; ISAKOS Scientific Committee. Practical aspects of randomization and blinding in randomized clinical trials. Arthroscopy. 2003 Nov; 19(9):1000-6.<\/li>\n
                • Enarson, D. a, Kennedy, S. M. & Miller, D. L. Choosing a research study design and selecting a population to study. Int. J. Tuberc. Lung Dis. 8, 1151\u20136 (2004).<\/li>\n
                • Forder, P. M., Gebski, V. J. & Keech, A. C. Allocation concealment and blinding: when ignorance is bliss. Med. J. Aust. 182, 87\u20139 (2005).<\/li>\n
                • Documenta\u00e7\u00e3o relativa \u00e0 \u00e9tica em pesquisa do Governo Federal http:\/\/222.datasus.gov.br\/conselho\/comissoes\/etica\/conep.htm (consultado em 03\/03\/2005)<\/li>\n
                • Higgins PA, Straub AJ. Understanding the error of our ways: mapping the concepts of validity and reliability. Nurs Outlook. 2006 Jan-Feb;54(1):23-9.<\/li>\n
                • Ravani, P., Parfrey, P. S., Dicks, E. & Barrett, B. J. Clinical research of kidney diseases II: problems of study design. Nephrol. Dial. Transplant 22, 2785\u201394 (2007).<\/li>\n
                • Hr\u00f3bjartsson, a, Forfang, E., Haahr, M. T., Als-Nielsen, B. & Brorson, S. Blinded trials taken to the test: an analysis of randomized clinical trials that report tests for the success of blinding. Int. J. Epidemiol. 36, 654\u201363 (2007).<\/li>\n
                • Boutron I, Guittet L, Estellat C, Moher D, Hr\u00f3bjartsson A, Ravaud P. Reporting methods of vlinding in randomized trials assessing nonpharmacological treatments. PLoS Med. 2007 Feb;4(2):e61; review<\/li>\n
                • Wang, R. et al. spe ci a l r ep or t Statistics in Medicine \u2014 Reporting of Subgroup Analyses in Clinical Trials. 2189\u20132194 (2007).<\/li>\n
                • Brauer CA, Neumann PJ, Rosen AB. Trends in cost effectiveness analyses in orthopaedic surgery. Clin Orthop Relat Res. 2007 Apr;457:42-8.<\/li>\n
                • Leslie Gross Portney, Mary P. Wathins. Foundations of Clinical Research: Applications to Practice (3rd edition) [Hardcover]; 2009.<\/li>\n
                • Abdul Latif, L., Daud Amadera, J. E., Pimentel, D., Pimentel, T. & Fregni, F. Sample size calculation in physical medicine and rehabilitation: a systematic review of reporting, characteristics, and results in randomized controlled trials. Arch. Phys. Med. Rehabil. 92, 306\u201315 (2011).<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
                  \n
                  <\/i><\/i>MOT5743 – ESCREVENDO O SEU ARTIGO CIENT\u00cdFICO<\/div>\n
                  \n

                  Sigla: MOT5743 – 1
                  \nNome: Escrevendo o seu Artigo Cient\u00edfico
                  \n\u00c1rea: Ci\u00eancias do Sistema Musculoesquel\u00e9tico (5140)
                  \nDatas de aprova\u00e7\u00e3o:
                  \nCCP: 17\/10\/2016
                  \nCPG: 08\/12\/2016
                  \nCoPGr:
                  \nData de ativa\u00e7\u00e3o: 08\/12\/2016
                  \nData de desativa\u00e7\u00e3o:<\/p>\n

                  Carga hor\u00e1ria:
                  \nTotal: 60 h
                  \nTe\u00f3rica: 3 h
                  \nPr\u00e1tica: 3 h
                  \nEstudo: 9 h
                  \nCr\u00e9ditos: 4
                  \nDura\u00e7\u00e3o: 4 Semanas<\/p>\n

                  Respons\u00e1veis:
                  \n57150 – Eloisa Silva Dutra de Oliveira Bonfa – 08\/12\/2016 at\u00e9 data atual
                  \n432902 – Eduardo Ferreira Borba Neto – 08\/12\/2016 at\u00e9 data atual
                  \n432902 – Eduardo Ferreira Borba Neto – 13\/06\/2019 at\u00e9 data atual
                  \n1891431 – Sandra Gofinet Pasoto – 13\/06\/2019 at\u00e9 data atual<\/p>\n

                  Objetivos:
                  \nA Disciplina tem como objetivo desenvolver a escrita de um trabalho cient\u00edfico atrav\u00e9s de um processo que envolve a an\u00e1lise cr\u00edtica e a pr\u00e1tica da reda\u00e7\u00e3o de um trabalho cient\u00edfico.<\/p>\n

                  Justificativa:
                  \nExiste a necessidade de treinamento dos alunos para a elabora\u00e7\u00e3o de trabalhos cient\u00edficos.<\/p>\n

                  Conte\u00fado:
                  \nA partir dos resultados obtidos para a elabora\u00e7\u00e3o de tese ser\u00e3o realizadas oficinas de reda\u00e7\u00e3o para os itens abaixo:
                  \nAutoria – crit\u00e9rio
                  \nDefini\u00e7\u00e3o de t\u00edtulo
                  \nReda\u00e7\u00e3o de abstract – metodologia e pr\u00e1tica
                  \nReda\u00e7\u00e3o da introdu\u00e7\u00e3o – metodologia e pr\u00e1tica
                  \nReda\u00e7\u00e3o da discuss\u00e3o – metodologia e pr\u00e1tica
                  \nCrit\u00e9rios usados pelos revisores para avalia\u00e7\u00e3o dos papers
                  \nForma de avalia\u00e7\u00e3o:
                  \nPresen\u00e7a\/Participa\u00e7\u00e3o
                  \nElabora\u00e7\u00e3o do paper<\/p>\n

                  Observac\u00e3o:
                  \n(Pr\u00e9- requisito para inscri\u00e7\u00e3o)
                  \nSer\u00e3o aceitos SOMENTE alunos que tenham resultados de sua tese j\u00e1 praticamente finalizada e em fase de an\u00e1lise cr\u00edtica para reda\u00e7\u00e3o. O curso depende desses dados para elabora\u00e7\u00e3o da reda\u00e7\u00e3o.
                  \nN\u00famero de alunos: m\u00ednimo: 8 e m\u00e1ximo 12<\/p>\n

                  Bibliografia:<\/p>\n

                    \n
                  • Mois\u00e9s M. Guia pr\u00e1tico de reda\u00e7\u00e3o. 3a ed. Ed. Cultrix, S\u00e3o Paulo, 1967.<\/li>\n
                  • Bachelard, G. O novo esp\u00edrito cient\u00edfico (L\u00ea nouvel esprit scientifique). Rio de Janeiro, Tempo Brasileiro, 1968.<\/li>\n
                  • Rey L. Como redigir trabalhos cient\u00edficos. Editora Edgard Bl\u00fccher\/Editora da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, 1972.<\/li>\n
                  • Bronowski J. O senso comum da ci\u00eancia. Belo Horizonte, Ed. Itatiaia\/Ed. Univ. S\u00e3o Paulo, 1977.<\/li>\n
                  • Castro CM. A pr\u00e1tica da pesquisa. S\u00e3o Paulo, McGraw Hill, 1978.<\/li>\n
                  • Castro CM. Estrutura e apresenta\u00e7\u00e3o de publica\u00e7\u00f5es cient\u00edficas. S\u00e3o Paulo, McGraw Hill, 1978.<\/li>\n
                  • Charadeau P. Langage et discours. Paris, Hadrette, 1983.28. CHATEAU, Jean Os Grandes Pedagogistas. S\u00e3o Paulo, Cia. Ed. Nacional, 1978.<\/li>\n
                  • Barrass, R. Os cientistas precisam escrever: guia de reda\u00e7\u00e3o para cientistas, engenheiros e estudantes. Editora da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, 1979.<\/li>\n
                  • How to Write and Publish a Scientific Paper. Robert A. Day, ISI Press, Philadelphia, PA, 1979.<\/li>\n
                  • Asti Vera, Armando. Metodologia da pesquisa cient\u00edfica. Porto Alegre: Globo, 1980.<\/li>\n
                  • Costa NCA. Ensaios sobre os fundamentos da L\u00f3gica, S\u00e3o Paulo, Hucitec, Edusp, 1980.<\/li>\n
                  • Bastos, L\u00edlia Da Rocha et al. Manual para a elabora\u00e7\u00e3o de projetos e relat\u00f3rios de pesquisas, teses e disserta\u00e7\u00f5es. 2a ed. Rio de Janeiro: Zahar, 1981.<\/li>\n
                  • Communication Skills for the Foreign Born Professional. Gregory A. Barnes, ISI Press, Philadelphia, PA, 1982.<\/li>\n
                  • Cervo AL, Bervian PA. Metodologia cient\u00edfica. S\u00e3o Paulo: MacGraw Hill do Brasil, 1983.<\/li>\n
                  • Beveridge WIB. Sementes da Descoberta Cient\u00edfica. Trad. S. Regis, S\u00e3o Paulo, TAQ, 1986.<\/li>\n
                  • Barros AJP, Lehfedl NAS. (1986). Fundamentos de metodologia. S\u00e3o Paulo, McGraw-Hill.<\/li>\n
                  • Bal, M. Teoria de la Narrativa. S\u00e3o Paulo, Atual, 1988.<\/li>\n
                  • Briscoe MH. Preparing scientific illustrations: a guide to better posters, presentations, and publications. Springer, New York, 1995.<\/li>\n
                  • Matthews JR, Bowen JM, Matthews RW. Successful scientific writing. Cambridge University Press, Cambridge, 1996.<\/li>\n
                  • Blikstein I. T\u00e9cnicas de comunica\u00e7\u00e3o escrita. \u00c1tica, S\u00e3o Paulo, 1997.<\/li>\n
                  • Volpato, GL. Publica\u00e7\u00e3o Cient\u00edfica. 2 ed. Botucatu, S.P:Tipomic; 2003.<\/li>\n
                  • Alexandrov AV, Hennerici MG. Writing good abstracts. Cerebrovasc Dis. 2007;23(4):256-9. Epub 2006 Dec 29. PubMed PMID: 17199082.<\/li>\n
                  • Van Way CW 3rd. Writing a scientific paper. Nutr Clin Pract. 2007 Dec;22(6):636-40.<\/li>\n
                  • Charlton BG. How can the English-language scientific literature be made more accessible to non-native speakers? Journals should allow greater use of referenced direct quotations in ‘component-oriented’ scientific writing. Med Hypotheses. 2007;69(6):1163-4.<\/li>\n
                  • Stang A, Schmidt-Pokrzywniak A. Submissions of scientific papers should not become a sophistication. J Clin Epidemiol. 2007 May; 60(5):535<\/li>\n
                  • Ram\u00f3n y Cajal S. Procedures in current practice on the writing of scientific papers. 1937. Clin Orthop Relat Res. 2007 Feb;455:14-7.<\/li>\n
                  • Mott Greene The demise of the lone authorNature 450, 1165 (20 December 2007)<\/li>\n
                  • Ng KH, Peh WC. Writing the materials and methods. Singapore Med J. 2008 Nov;49(11):856-8<\/li>\n
                  • \u00d8vretveit J. Writing a scientific publication for a management journal. JHealth Organ Manag. 2008;22(2):189-206.<\/li>\n
                  • Peh WC, Ng KH. Basic structure and types of scientific papers. Singapore Med J. 2008 Jul;49(7):522-5.<\/li>\n
                  • Ioannidis JP. Measuring co-authorship and networking-adjusted scientific impact. PLoS One. 2008 Jul 23; 3(7):e 2778.<\/li>\n
                  • Fahy K. Writing for publication: argument and evidence. Women Birth. 2008 Sep;21(3):113-7.<\/li>\n
                  • Looi LM. Nurturing young writers: sustaining quality, not quantity. Singapore Med J. 2009 Nov;50(11):1044-7.<\/li>\n
                  • Sismondo S. Ghosts in the machine: publication planning in the medical sciences. Soc Stud Sci. 2009 Apr;39(2):171-98.<\/li>\n
                  • Ng KH, Peh WC. Preparing effective tables. Singapore Med J. 2009 Feb;50(2):117-8<\/li>\n
                  • Singh S, Chaudhary R, Suvirya S. Scientific precision in titles of research papers published in three dermatology journals. J Am Acad Dermatol. 2009 Mar; 60(3):e 7-e 15.<\/li>\n
                  • Mat\u00edas-Guiu J, Garc\u00eda-Ramos R. [Author and authorship in medical journals]. Neurologia. 2009 Jan-Feb;24(1):1-6.<\/li>\n
                  • G\u00f8tzsche PC, Kassirer JP, Woolley KL, Wager E, Jacobs A, Gertel A, Hamilton C. What should be done to tackle ghostwriting in the medical literature? PLoS Med. 2009 Feb 3;6(2):e 23.<\/li>\n
                  • Walsh PJ, Mommsen TP, Nilsson GE. The do’s and don’t’s of submitting scientific papers. Comp Biochem Physiol B Biochem Mol Biol. 2009 Mar;152(3):203-4.<\/li>\n
                  • Wager E. Recognition, reward and responsibility: why the authorship of scientific papers matters. Maturitas. 2009 Feb 20;62(2):109-12.<\/li>\n
                  • Heckenberg A, Druml C. Gender aspects in medical publication – the Wiener klinische Wochenschrift. Wien Klin Wochenschr. 2010 Mar;122(5-6):141-5.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
                    \n
                    <\/i><\/i>MOT5744 – CI\u00caNCIA DO SISTEMA MUSCULOESQUEL\u00c9TICO BASEADA EM EVID\u00caNCIAS<\/div>\n
                    \n

                    Sigla: MOT5744 – 2
                    \nNome: Ci\u00eancia do Sistema M\u00fasculo-Esquel\u00e9tico Baseada em Evid\u00eancias
                    \n\u00c1rea: Ci\u00eancias do Sistema Musculoesquel\u00e9tico (5140)<\/p>\n

                    Datas de aprova\u00e7\u00e3o:
                    \nCCP: 22\/03\/2022
                    \nCPG: 09\/06\/2022
                    \nCoPGr:
                    \nData de ativa\u00e7\u00e3o: 09\/06\/2022
                    \nData de desativa\u00e7\u00e3o:<\/p>\n

                    Carga hor\u00e1ria:
                    \nTotal: 120 h
                    \nTe\u00f3rica:1 h
                    \nPr\u00e1tica:4 h
                    \nEstudo:5 h
                    \nCr\u00e9ditos:8
                    \nDura\u00e7\u00e3o:12 Semanas<\/p>\n

                    Respons\u00e1veis:
                    \n1545598 – Olavo Pires de Camargo – 09\/06\/2022 at\u00e9 data atual
                    \n2358177 – Riccardo Gomes Gobbi – 09\/06\/2022 at\u00e9 data atual
                    \n3734237 – Marco Kawamura Demange – 09\/06\/2022 at\u00e9 data atual
                    \n7105361 – Eduardo Angeli Malavolta – 09\/06\/2022 at\u00e9 data atual<\/p>\n

                    Objetivos:<\/p>\n

                    Oferecer ao aluno da p\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias do Sistema M\u00fasculo-Esquel\u00e9tico ou de outras \u00e1reas interessadas, revis\u00e3o e debate sobre temas atuais e relevantes na Ortopedia moderna, com an\u00e1lise cr\u00edtica baseada em evid\u00eancias das pr\u00e1ticas terap\u00eauticas. Os alunos ter\u00e3o oportunidade de se atualizar nos temas discutidos, ao mesmo tempo em que refor\u00e7am conceitos sobre metodologia cient\u00edfica.<\/p>\n

                    Justificativa:<\/p>\n

                    A leitura de artigos exige conhecimento dos m\u00e9todos cient\u00edficos para que a real relev\u00e2ncia de cada estudo para a pr\u00e1tica cl\u00ednica seja estabelecida. Com a pletora de artigos cient\u00edficos sendo publicados todos os meses, os alunos de p\u00f3s-gradua\u00e7\u00e3o necessitam de ferramentas para analisar criticamente esses artigos sob a luz da medicina baseada em evid\u00eancias.<\/p>\n

                    Conte\u00fado:<\/p>\n

                    O curso ser\u00e1 dividido em m\u00f3dulos semanais, abordando temas relevantes do sistema m\u00fasculo-esquel\u00e9tico (Introdu\u00e7\u00e3o a medicina baseada em evid\u00eancias, Trauma dos membros superiores, Trauma dos membros inferiores, Coluna, Ombro e Cotovelo, M\u00e3o e Microcirurgia, Quadril, Joelho, P\u00e9 e Tornozelo, Medicina Esportiva e Educa\u00e7\u00e3o F\u00edsica e Reumatologia). Os alunos ter\u00e3o acesso a um bloco de aulas do tema em quest\u00e3o e a artigos sobre os temas para estudo e discuss\u00e3o no f\u00f3rum online. Ao final do curso, os alunos ter\u00e3o realizado estudo cr\u00edtico sobre os principais temas da \u00e1rea. Ser\u00e3o priorizados estudos do maior n\u00edvel de evid\u00eancia dispon\u00edvel e revis\u00f5es sistem\u00e1ticas\/metan\u00e1lises, expondo tratamentos usuais que n\u00e3o tem respaldo cient\u00edfico robusto e possibilidades futuras de pesquisa com intuito de esclarecer lacunas do conhecimento.<\/p>\n

                    Crit\u00e9rios de avalia\u00e7\u00e3o:
                    \nParticipa\u00e7\u00e3o ativa semanal nas discuss\u00f5es do f\u00f3rum online, frequ\u00eancia na visualiza\u00e7\u00e3o das aulas e apresenta\u00e7\u00e3o de um artigo relevante sobre o tema do projeto de p\u00f3s-gradua\u00e7\u00e3o de cada aluno ao final do curso.<\/p>\n

                    Observa\u00e7\u00f5es:
                    \nEsta disciplina ser\u00e1 ministrada atrav\u00e9s de atividade online – f\u00f3rum em grupo com todos os alunos e os docentes, aulas gravadas sobre o tema da semana e apresenta\u00e7\u00e3o de trabalho selecionado pelo aluno de \u00e1rea relevante ao seu projeto de p\u00f3s-gradua\u00e7\u00e3o.<\/p>\n

                    Bibliografia:<\/p>\n

                      \n
                    • Gotzsche PC. Blinding during data analysis and writing of manuscripts. Control Clin Trials. 1996;17(4):285-90.<\/li>\n
                    • Black N. Evidence-based surgery: a passing fad? World J Surg. 1999;23(8):789-93.<\/li>\n
                    • Freedman KB, Back S, Bernstein J. Sample size and statistical power of randomised, controlled trials in orthopaedics. J Bone Joint Surg Br. 2001;83(3):397-402.<\/li>\n
                    • Lochner HV, Bhandari M, Tornetta P. Type-II error rates (beta errors) of randomized trials in orthopaedic trauma. J Bone Joint Surg. 2001;83(11):1650-5.<\/li>\n
                    • Bhandari M, Richards RR, Sprague S, Schemitsch EH. The quality of reporting of randomized trials in The Journal of Bone and Joint Surgery from 1988 through 2000. J Bone Joint Surg Am. 2002;84(3):388-96.<\/li>\n
                    • Schulz KF, Grimes DA. Blinding in randomised trials: hiding who got what. Lancet. 2002;359(9307):696-700.<\/li>\n
                    • Boutron I, Tubach F, Giraudeau B, Ravaud P. Blinding was judged more difficult to achieve and maintain in nonpharmacologic than pharmacologic trials. J Clin Epidemiol. 2004;57(6):543-50.<\/li>\n
                    • Bhandari M, Jonsson A, Buhren V. Conducting industry-partnered trials in orthopaedic surgery. Injury. 2006;37(4):361-6.<\/li>\n
                    • Zlowodzki M, Jonsson A, Bhandari M. Common pitfalls in the conduct of clinical research. Med Princ Pract. 2006;15(1)1-8.<\/li>\n
                    • Abraham NS, Young JM, Solomon MJ. A systematic review of reasons for nonentry of eligible patients into surgical randomized controlled trials. Surgery. 2006;139(4):469-83.<\/li>\n
                    • Lynch JR, Cunningham MRA, Warme WJ, Schaad DC, Wolf FM, Leopold SS. Commercially funded and United States-based research is more likely to be published; Good-quality studies with negative outcomes are not. J Bone Joint Surg. 2007;89(5):1010-8.<\/li>\n
                    • Chaudhry H, Mundi R, Singh I, Einhorn TA, Bhandari M. How good is the orthopaedic literature. Indian J Orthop. 2008;42(2):144-9.<\/li>\n
                    • Soucacos PN, Johnson EO, Babis G. Randomised controlled trials in orthopaedic surgery and traumatology: overview of parameters and pitfalls. Injury. 2008;39(6):636-42.<\/li>\n
                    • Paradis C. Bias in surgical research. Ann Surg. 2008;248(2):180-8.<\/li>\n
                    • Portney LG, Watkins MP. Validity in experimental design. In: Portney LG, Watkins MP, editores. Foundations of clinical research – applications to practice. 3rd ed. New Jersey: Pearson Prentice Hall; 2009. p. 161-91.<\/li>\n
                    • Herman A, Botser IB, Tenenbaum S, Chechick A. Intention-to-Treat Analysis and Accounting for Missing Data in Orthopedic Randomized Clinical Trials. J Bone Joint Surg Am. 2009;91(9):2137-43.<\/li>\n
                    • Ahmad N, Boutron I, Moher D, Pitrou I, Roy C, Ravaud P. Neglected external validity in reports of randomized trials: the example of hip and knee osteoarthritis. Arthritis Rheum. 2009;61(3):361-9.<\/li>\n
                    • Malavolta EA, Demange MK, Gobbi RG, Imamura M, Fregni F. Ensaios clinicos controlados e randomizados na ortopedia: dificuldades e limitac\u00f5es. Rev Bras Ortop. 2011;46(4):452-59.<\/li>\n
                    • Mohit Bhandari, editor-in-chief. Evidence-based orthopedics. New Jersey: Wiley-Blackwell; 2012.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
                      \n
                      <\/i><\/i>MOT5745 – OSTEOMETABOLISMO, IMAGEM E TRATAMENTO DE DOEN\u00c7AS \u00d3SSEAS<\/div>\n
                      \n

                      Sigla: MOT5745 – 1
                      \nNome: Osteometabolismo, Imagem e Tratamento de Doen\u00e7as \u00d3sseas
                      \n\u00c1rea: Ci\u00eancias do Sistema Musculoesquel\u00e9tico (5140)<\/p>\n

                      Datas de aprova\u00e7\u00e3o:
                      \nCCP: 28\/05\/2019
                      \nCPG: 28\/05\/2019
                      \nCoPGr:
                      \nData de ativa\u00e7\u00e3o: 28\/05\/2019
                      \nData de desativa\u00e7\u00e3o:<\/p>\n

                      Carga hor\u00e1ria:
                      \nTotal: 75 h
                      \nTe\u00f3rica:2 h
                      \nPr\u00e1tica:6 h
                      \nEstudo:7 h
                      \nCr\u00e9ditos:5
                      \nDura\u00e7\u00e3o:5 Semanas<\/p>\n

                      Respons\u00e1veis:
                      \n1690250 – Rosa Maria Rodrigues Pereira – 28\/05\/2019 at\u00e9 data atual
                      \n3157971 – Luciana Parente Costa Seguro – 28\/05\/2019 at\u00e9 data atual
                      \n7499069 – Diogo Souza Domiciano – 28\/05\/2019 at\u00e9 data atual<\/p>\n

                      Objetivos:
                      \nA Disciplina tem como objetivo apresentar e discutir conhecimentos avan\u00e7ados em osteometabolismo, fisiopatologia, diagn\u00f3stico e tratamento de doen\u00e7as osteometab\u00f3licas.<\/p>\n

                      Justificativa:
                      \nO osteometabolismo tem ganhado cada vez mais import\u00e2ncia na patog\u00eanese e tratamento de doen\u00e7as que s\u00e3o alvo de estudo de v\u00e1rias especialidades m\u00e9dicas (Reumatologia, Endocrinologia, Gastroenterologia, Geriatria, Ginecologia, Oncologia, etc.). Portanto, seu conhecimento torna-se cada vez mais importante na forma\u00e7\u00e3o do pesquisador, m\u00e9dico em in\u00fameros campos da medicina. Recentemente h\u00e1 v\u00e1rias inova\u00e7\u00f5es na \u00e1rea de diagn\u00f3stico por imagem incluindo novas tecnologias como tomografia \u00f3ssea, TBS e novos softwares ligados \u00e0 DXA, osteoimunologia e marcadores inflamat\u00f3rios em doen\u00e7as que envolvem causas secund\u00e1rias de osteoporose.<\/p>\n

                      Conte\u00fado:
                      \nSer\u00e3o convidados especialistas em diferentes \u00e1reas de conhecimento do Metabolismo \u00d3sseo para discutir os temas, seguido pela apresenta\u00e7\u00e3o de artigos cient\u00edficos relacionados ao assunto de cada dia. Os semin\u00e1rios ser\u00e3o apresentados pelos alunos, em forma de aula expositiva (PowerPoint) e discuss\u00e3o livre.
                      \n1. Osteoimunologia (c\u00e9lulas, principais vias de sinaliza\u00e7\u00e3o molecular, inflama\u00e7\u00e3o e osso)
                      \n2. Imagem em Osteometabolismo (DXA, VFA, TBS e HR-pQCT)
                      \n3. Bi\u00f3psia \u00f3ssea e Histomorfometria \/ Doen\u00e7a \u00d3ssea Renal
                      \n4. Vitamina D \u2013 A\u00e7\u00f5es Extra-esquel\u00e9ticas
                      \n5. Biol\u00f3gicos em Osteoporose (Denosumabe e Romosozumabe) \/ Uso de agentes antirreabsortivos \u00f3sseos em C\u00e2ncer
                      \n6. Composi\u00e7\u00e3o Corporal \/ Tecido Adiposo Visceral por DXA e Sarcopenia<\/p>\n

                      Forma de avalia\u00e7\u00e3o:
                      \n1. Presen\u00e7a\/Participa\u00e7\u00e3o
                      \n2. Apresenta\u00e7\u00e3o de semin\u00e1rios \/ artigos cient\u00edficos<\/p>\n

                      Observa\u00e7\u00e3o:
                      \nN\u00famero de alunos: m\u00ednimo 8 e m\u00e1ximo 30<\/p>\n

                      Tipo de oferecimento da disciplina: Presencial<\/p>\n

                      Bibliografia:<\/p>\n

                        \n
                      • Smith MR, Egerdie B, Hern\u00e1ndez Toriz N, Feldman R, Tammela TL, Saad F, et al. Denosumab HALT Prostate Cancer Study Group. Denosumab in men receiving androgen-deprivation therapy for prostate cancer. N Engl J Med. 2009;361(8):745-55.<\/li>\n
                      • Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39(4):412-23.<\/li>\n
                      • Adami S, Libanati C, Boonen S, Cummings SR, Ho PR, Wang A, Siris E et al. Denosumab treatment in postmenopausal women with osteoporosis does not interfere with fracture-healing: results from the FREEDOM trial. J Bone Joint Surg Am. 2012;94(23):2113-9.<\/li>\n
                      • Schousboe JT, Shepherd JA, Bilezikian JP, Baim S. Executive summary of the 2013 International Society for Clinical Densitometry Position Development Conference on bone densitometry. J Clin Densitom. 2013;16(4):455-66.<\/li>\n
                      • Domiciano DS, Figueiredo CP, Lopes JB, Kuroishi ME, Takayama L, Caparbo VF, et al. Vertebral fracture assessment by dual X-ray absorptiometry: a valid tool to detect vertebral fractures in community-dwelling older adults in a population-based survey. Arthritis Care Res (Hoboken). 2013;65(5):809-15.<\/li>\n
                      • Dempster DW, Compston JE, Drezner MK, Glorieux FH, Kanis JA, Malluche H, et al. Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res. 2013;28(1):2-17.<\/li>\n
                      • Carvalho AB, Carneiro R, Leme GM, Rochitte CE, Santos RD, Miname MH, et al. Vertebral bone density by quantitative computed tomography mirrors bone structure histomorphometric parameters in hemodialysis patients. J Bone Miner Metab. 2013;31(5):551-5.<\/li>\n
                      • Shepherd JA, Baim S, Bilezikian JP, Schousboe JT. Executive summary of the 2013 International Society for Clinical Densitometry Position Development Conference on Body Composition. J Clin Densitom. 2013;16(4):489-95.<\/li>\n
                      • Petak S, Barbu CG, Yu EW, Fielding R, Mulligan K, Sabowitz B, Wu CH, Shepherd JA. The Official Positions of the International Society for Clinical Densitometry: body composition analysis reporting. J Clin Densitom. 2013;16(4):508-19.<\/li>\n
                      • Domiciano DS, Figueiredo CP, Lopes JB, Caparbo VF, Takayama L, Menezes PR, et al. Discriminating sarcopenia in community-dwelling older women with high frequency of overweight\/obesity: the S\u00e3o Paulo Ageing & Health Study (SPAH). Osteoporos Int. 2013;24(2):595-603.<\/li>\n
                      • Iki M, Tamaki J, Kadowaki E, Sato Y, Dongmei N, Winzenrieth R, et al. Trabecular bone score (TBS) predicts vertebral fractures in Japanese women over 10 years independently of bone density and prevalente vertebral deformity: the Japanese Population-Based Osteoporosis (JPOS) cohort study. J Bone Miner Res. 2014;29(2):399-407.<\/li>\n
                      • Figueiredo CP, Domiciano DS, Lopes JB, Caparbo VF, Scazufca M, Bonf\u00e1 E et al. Prevalence of sarcopenia and associated risk factors by two diagnostic criteria in community-dwelling older men: the S\u00e3o Paulo Ageing & Health Study (SPAH). Osteoporos Int. 2014;25(2):589-96.<\/li>\n
                      • Cruz-Jentoft AJ, Landi F, Schneider SM, Z\u00fa\u00f1iga C, Arai H, Boirie Y, et al. Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS). Age Ageing. 2014;43(6):748-59.<\/li>\n
                      • McLean RR, Shardell MD, Alley DE, Cawthon PM, Fragala MS, Harris TB, et al. Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the foundation for the National Institutes of Health (FNIH) sarcopenia project. J Gerontol A Biol Sci Med Sci. 2014;69(5):576-83.<\/li>\n
                      • McLean RR, Kiel DP. Developing consensus criteria for sarcopenia: an update. J Bone Miner Res. 2015;30(4):588-92.<\/li>\n
                      • de Souza CG, Jorgetti V, Dos Reis LM, Croci AT. Histomorphometric analysis of the femoral neck in patients with and without femoral neck fracture. Acta Ortop Bras. 2015;23(2):98-102.<\/li>\n
                      • Machado KL, Domiciano DS, Machado LG, Lopes JB, Figueiredo CP, Takayama L, et al. Persistent hypovitaminosis D and loss of hip bone mineral density over time as additional risk factors for recurrent falls in a population-based prospective cohort of elderly persons living in the community. The S\u00e3o Paulo Ageing & Health (SPAH) Study. Osteoporos Int. 2015;26(5):1535-42.<\/li>\n
                      • Sugimoto T, Matsumoto T, Hosoi T, Miki T, Gorai I, Yoshikawa H, et al. Three-year denosumab treatment in postmenopausal Japanese women and men with osteoporosis: results from a 1-year open-label extension of the Denosumab Fracture Intervention Randomized Placebo Controlled Trial (DIRECT). Osteoporos Int. 2015;26(2):765-74.<\/li>\n
                      • Rossini M, Viapiana O, Adami S, Idolazzi L, Fracassi E, Gatti D. Focal bone involvement in inflammatory arthritis: the role of IL17. Rheumatol Int. 2016;36(4):469-82.<\/li>\n
                      • Lee JH, Lee YK, Oh SH, Ahn J, Lee YE, Pyo JH, Choi YY, Kim D, Bae SC, Sung YK, Kim DY. A systematic review of diagnostic accuracy of vertebral fracture assessment (VFA) in postmenopausal women and elderly men. Osteoporos Int. 2016;27(5):1691-9.<\/li>\n
                      • McCloskey EV, Od\u00e9n A, Harvey NC, Leslie WD, Hans D, Johansson H, Barkmann R, et al. A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX. J Bone Miner Res. 2016;31(5):940-8.<\/li>\n
                      • Cosman F, Crittenden DB, Adachi JD, Binkley N, Czerwinski E, Ferrari S, et al. Romosozumab Treatment in Postmenopausal Women with Osteoporosis. N Engl J Med. 2016;375(16):1532-1543.<\/li>\n
                      • Messina C, Monaco CG, Ulivieri FM, Sardanelli F, Sconfienza LM. Dual-energy X-ray absorptiometry body composition in patients with secondary osteoporosis. Eur J Radiol. 2016;85(8):1493-8.<\/li>\n
                      • Machado LG, Domiciano DS, Figueiredo CP, Caparbo VF, Takayama L, Oliveira RM, et al. Visceral fat measured by DXA is associated with increased risk of non-spine fractures in nonobese elderly women: a population-based prospective cohort analysis from the S\u00e3o Paulo Ageing & Health (SPAH) Study. Osteoporos Int. 2016;27(12):3525-3533.<\/li>\n
                      • Bahat G, Tufan A, Tufan F, Kilic C, Akpinar TS, Kose M, et al. Cut-off points to identify sarcopenia according to European Working Group on Sarcopenia in Older People (EWGSOP) definition. Clin Nutr. 2016;35(6):1557-1563.<\/li>\n
                      • Zerbini CAF, Clark P, Mendez-Sanchez L, Pereira RMR, Messina OD, U\u00f1a CR, Adachi JD, Lems WF, Cooper C, Lane NE; IOF Chronic Inflammation and Bone Structure (CIBS) Working Group. Biologic therapies and bone loss in rheumatoid arthritis. Osteoporos Int. 2017;28(2):429-446.<\/li>\n
                      • Okamoto K, Nakashima T, Shinohara M, Negishi-Koga T, Komatsu N, Terashima A, et al. Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems. Physiol Rev. 2017;97(4):1295-1349.<\/li>\n
                      • Malgo F, Hamdy NAT, Ticheler CHJM, Smit F, Kroon HM, Rabelink TJ, et al. Value and potential limitations of vertebral fracture assessment (VFA) compared to conventional spine radiography: experience from a fracture liaison service (FLS) and a meta-analysis. Osteoporos Int. 2017;28(10):2955-2965.<\/li>\n
                      • Zeytinoglu M, Jain RK, Vokes TJ. Vertebral fracture assessment: Enhancing the diagnosis, prevention, and treatment of osteoporosis. Bone. 2017;104:54-65.<\/li>\n
                      • Schousboe JT, Vo TN, Langsetmo L, Taylor BC, Cawthon PM, Schwartz AV, Bauer DC, Orwoll ES, Lane NE, Barrett-Connor E, Ensrud KE; Osteoporotic Fractures in Men (MrOS) Study Research Group. Association of Trabecular Bone Score (TBS) With Incident Clinical and Radiographic Vertebral Fractures Adjusted for Lumbar Spine BMD in Older Men: A Prospective Cohort Study. J Bone Miner Res. 2017;32(7):1554-1558.<\/li>\n
                      • Martineau P, Leslie WD, Johansson H, Oden A, McCloskey EV, Hans D, Kanis JA. Clinical Utility of Using Lumbar Spine Trabecular Bone Score to Adjust Fracture Probability: The Manitoba BMD Cohort. J Bone Miner Res. 2017;32(7):1568-1574.<\/li>\n
                      • Leslie WD, Majumdar SR, Morin SN, Hans D, Lix LM. Change in Trabecular Bone Score (TBS) With Antiresorptive Therapy Does Not Predict Fracture in Women: The Manitoba BMD Cohort. J Bone Miner Res. 2017;32(3):618-623.<\/li>\n
                      • Marques ID, Ara\u00fajo MJ, Graciolli FG, Reis LM, Pereira RM, Cust\u00f3dio MR, et al. Biopsy vs. peripheral computed tomography to assess bone disease in CKD patients on dialysis: differences and similarities. Osteoporos Int. 2017;28(5):1675-1683.<\/li>\n
                      • Autier P, Mullie P, Macacu A, Dragomir M, Boniol M, Coppens K, Pizot C, Boniol M. Effect of vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomised trials. Lancet Diabetes Endocrinol. 2017;5(12):986-1004.<\/li>\n
                      • Franco AS, Freitas TQ, Bernardo WM, Pereira RMR. Vitamin D supplementation and disease activity in patients with immune-mediated rheumatic diseases: A systematic review and meta-analysis. Medicine (Baltimore). 2017;96(23):e7024.<\/li>\n
                      • Mhaskar R, Kumar A, Miladinovic B, Djulbegovic B. Bisphosphonates in multiple myeloma: an updated network meta-analysis. Cochrane Database Syst Rev. 2017;12:CD003188.<\/li>\n
                      • Saag KG, Petersen J, Brandi ML, Karaplis AC, Lorentzon M, Thomas T, et al. Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis. N Engl J Med. 2017;377(15):1417-1427.<\/li>\n
                      • Bone HG, Wagman RB, Brandi ML, Brown JP, Chapurlat R, Cummings SR, et al. 10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension. Lancet Diabetes Endocrinol. 2017;5(7):513-523.<\/li>\n
                      • O’Carrigan B, Wong MH, Willson ML, Stockler MR, Pavlakis N, Goodwin A. Bisphosphonates and other bone agents for breast cancer. Cochrane Database Syst Rev. 2017;10:CD003474.<\/li>\n
                      • Schousboe JT, Langsetmo L, Schwartz AV, Taylor BC, Vo TN, Kats AM, Barrett-Connor E, Orwoll ES, Marshall LM, Miljkovic I, Lane NE, Ensrud KE; Osteoporotic Fractures in Men (MrOS) Study Research Group. Comparison of Associations of DXA and CT Visceral Adipose Tissue Measures With Insulin Resistance, Lipid Levels, and Inflammatory Markers. J Clin Densitom. 2017;20(2):256-264.<\/li>\n
                      • Marzetti E, Calvani R, Tosato M, Cesari M, Di Bari M, Cherubini A, Collamati A, D’Angelo E, Pahor M, Bernabei R, Landi F; SPRINTT Consortium. Sarcopenia: an overview. Aging Clin Exp Res. 2017;29(1):11-17.<\/li>\n
                      • Kommalapati A, Tella SH, Esquivel MA, Correa R. Evaluation and management of skeletal disease in cancer care. Crit Rev Oncol Hematol. 2017;120:217-226.Erratum in: Crit Rev Oncol Hematol. 2018;26.<\/li>\n
                      • Walsh MC, Takegahara N, Kim H, Choi Y. Updating osteoimmunology: regulation of bone cells by innate and adaptive immunity. Nat Rev Rheumatol. 2018;14(3):146-156.<\/li>\n
                      • Hsu E, Pacifici R. From Osteoimmunology to Osteomicrobiology: How the Microbiota and the Immune System Regulate Bone. Calcif Tissue Int. 2018;102(5):512-521.<\/li>\n
                      • Okamoto K, Nakashima T, Shinohara M, Negishi-Koga T, Komatsu N, Terashima A, et al. Osteoimmunology: The Conceptual 1. Terashima A, Takayanagi H. Overview of Osteoimmunology. Calcif Tissue Int.2018;102(5):503-511.<\/li>\n
                      • Walsh MC, Takegahara N, Kim H, Choi Y. Updating osteoimmunology: regulation of bone cells by innate and adaptive immunity. Nat Rev Rheumatol. 2018;14(3):146-156.<\/li>\n
                      • Hsu E, Pacifici R. From Osteoimmunology to Osteomicrobiology: How the Microbiota and the Immune System Regulate Bone. Calcif Tissue Int. 2018;102(5):512-521.<\/li>\n
                      • Alvarenga JC, Boyd SK, Pereira RMR. The relationship between estimated bone strength by finite element analysis at the peripheral skeleton to areal BMD and trabecular bone score at lumbar spine. Bone. 2018;117:47-53.<\/li>\n
                      • Ramalho J, Marques IDB, Hans D, Dempster D, Zhou H, Patel P, Pereira RMR, Jorgetti V, Moyses RMA, Nickolas TL. The trabecular bone score: Relationships with trabecular and cortical microarchitecture measured by HR-pQCT and histomorphometry in patients with chronic kidney disease. Bone. 2018;116:215-220.<\/li>\n
                      • Figueiredo CP, Kleyer A, Simon D, Stemmler F, d’Oliveira I, Weissenfels A, Museyko O, Friedberger A, Hueber AJ, Haschka J, Englbrecht M, Pereira RMR, Rech J, Schett G, Engelke K. Methods for segmentation of rheumatoid arthritis bone erosions in high-resolution peripheral quantitative computed tomography (HR-pQCT). Semin Arthritis Rheum. 2018;47(5):611-618.<\/li>\n
                      • Leslie WD, Johansson H, McCloskey EV, Harvey NC, Kanis JA, Hans D. Comparison of Methods for Improving Fracture Risk Assessment in Diabetes: The Manitoba BMD Registry. J Bone Miner Res. 2018;33(11):1923-1930.<\/li>\n
                      • Santos MFP, Hern\u00e1ndez MJ, de Oliveira IB, Siqueira FR, Dominguez WV, Dos Reis LM, et al. Comparison of clinical, biochemical and histomorphometric analysis of bone biopsies in dialysis patients with and without fractures. J Bone Miner Metab. 2018; Jan 25.<\/li>\n
                      • Lima GL, Paupitz JA, Aikawa NE, Alvarenga JC, Pereira RMR. A randomized double-blind placebo-controlled trial of vitamin D supplementation in juvenile-onset systemic lupus erythematosus: positive effect on trabecular microarchitecture using HR-pQCT. Osteoporos Int. 2018;29(3):587-594.<\/li>\n
                      • Mayor S. Vitamin D does not reduce cancer or cardiovascular events in healthy adults, trial finds. BMJ. 2018;363:k4776.<\/li>\n
                      • Zheng JS, Imamura F, Sharp SJ, van der Schouw YT, Sluijs I, Gundersen TE, Ardanaz E, Boeing H, Bonet C, G\u00f3mez JH, Dow C, Fagherazzi G, Franks PW, Jenab M, K\u00fchn T, Kaaks R, Key TJ, Khaw KT, Lasheras C, Mokoroa O, Mancini FR, Nilsson PM, Overvad K, Panico S, Palli D, Rolandsson O, Sieri S, Salamanca-Fern\u00e1ndez E, Sacerdote C, Spijkerman AMW, Stepien M, Tjonneland A, Tumino R, Butterworth AS, Riboli E, Danesh J, Langenberg C, Forouhi NG, Wareham NJ. Association of Plasma Vitamin D Metabolites With Incident Type 2 Diabetes: EPIC-InterAct Case-Cohort Study. J Clin Endocrinol Metab. 2019 Apr 1;104(4):1293-1303.<\/li>\n
                      • Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, Gibson H, Gordon D, Copeland T, D’Agostino D, Friedenberg G, Ridge C, Bubes V, Giovannucci EL, Willett WC, Buring JE; VITAL Research Group. Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease. N Engl J Med. 2019 Jan 3;380(1):33-44.<\/li>\n
                      • Grammatiki M, Karras S, Kotsa K. The role of vitamin D in the pathogenesis and treatment of diabetes mellitus: a narrative review. Hormones (Athens). 2019
                        \nMar;18(1):37-48.<\/li>\n
                      • Umar M, Sastry KS, Chouchane AI. Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies. Int J Mol Sci. 2018
                        \nMay 30;19(6):1618.<\/li>\n
                      • Saad F, Sternberg CN, Mulders PFA, Niepel D, Tombal BF. The role of bisphosphonates or denosumab in light of the availability of new therapies for prostate cancer. Cancer Treat Rev. 2018;68:25-37.<\/li>\n
                      • Dorff TB, Agarwal N. Bone-targeted therapies to reduce skeletal morbidity in prostate cancer. Asian J Androl. 2018;20(3):215-220.<\/li>\n
                      • Menshawy A, Mattar O, Abdulkarim A, Kasem S, Nasreldin N, Menshawy E, et al. Denosumab versus bisphosphonates in patients with advanced cancers-related bone metastasis: systematic review and meta-analysis of randomized controlled trials. Support Care Cancer. 2018;26(4):1029-1038.<\/li>\n
                      • Yee AJ, Raje NS. Denosumab for the treatment of bone disease in solid tumors and multiple myeloma. Future Oncol. 2018;14(3):195-203.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
                        \n
                        <\/i><\/i>MOT5746 – FISIOPATOG\u00caNESE DAS DOEN\u00c7AS MUSCULARES ADQUIRIDAS<\/div>\n
                        \n

                        Sigla: MOT5746 – 2
                        \nNome: Fisiopatog\u00eanese das Doen\u00e7as Musculares Adquiridas
                        \n\u00c1rea: Ci\u00eancias do Sistema Musculoesquel\u00e9tico (5140)<\/p>\n

                        Datas de aprova\u00e7\u00e3o:
                        \nCCP: 23\/10\/2019
                        \nCPG: 12\/12\/2019
                        \nCoPGr:
                        \nData de ativa\u00e7\u00e3o:12\/12\/2019
                        \nData de desativa\u00e7\u00e3o:<\/p>\n

                        Carga hor\u00e1ria:
                        \nTotal: 45 h
                        \nTe\u00f3rica:3 h
                        \nPr\u00e1tica: 1 h
                        \nEstudo: 11 h
                        \nCr\u00e9ditos:3
                        \nDura\u00e7\u00e3o:3 Semanas<\/p>\n

                        Respons\u00e1veis:
                        \n2223976 – Samuel Katsuyuki Shinjo – 12\/12\/2019 at\u00e9 data atual
                        \n8872064 – Fernando Henrique Carlos de Souza – 12\/12\/2019 at\u00e9 data atual<\/p>\n

                        Objetivos:
                        \nAbordagem de mecanismo fisiopatog\u00eanico de doen\u00e7as musculares adquiridas, com enfoque para \u00e0s inflamat\u00f3rias.<\/p>\n

                        Justificativa:
                        \nNos \u00faltimos anos tem se observado grandes avan\u00e7os, por exemplo a) na caracteriza\u00e7\u00e3o do mecanismo fisiopatog\u00eanico de doen\u00e7as musculares inflamat\u00f3rias, principalmente com o advento de diversos autoanticorpos miosite-espec\u00edficos e miosite-associados; b) reclassifica\u00e7\u00e3o das doen\u00e7as musculares inflamat\u00f3rias, baseando-se no item anterior.<\/p>\n

                        Conte\u00fado:
                        \nAbordagem das doen\u00e7as musculares, com enfoque para \u00e0s inflamat\u00f3rias adquiridas (dermatomiosite, dermatomiosite clinicamente amiop\u00e1tica, polimiosite, miopatia necrosante imunomediada, s\u00edndrome antissintetase, miosite por corpos de inclus\u00e3o):
                        \n– Mecanismo fisiopatog\u00eanico (molecular e histol\u00f3gico)
                        \n– Caracteriza\u00e7\u00e3o dos diversos autoanticorpos miosite-espec\u00edficos e miosite-associados e sua correla\u00e7\u00e3o com o item anterior
                        \n– Relev\u00e2ncia dos itens anteriores na reclassifica\u00e7\u00e3o dos tipos de miopatias inflamat\u00f3rias e no progn\u00f3stico<\/p>\n

                        Forma de avalia\u00e7\u00e3o:
                        \nApresenta\u00e7\u00e3o dos semin\u00e1rios
                        \nParticipa\u00e7\u00e3o ativa nas discuss\u00f5es durante as apresenta\u00e7\u00f5es dos semin\u00e1rios
                        \nEvolu\u00e7\u00e3o do conhecimento
                        \nPresen\u00e7a: > 80% de frequ\u00eancia<\/p>\n

                        Tipo de oferecimento da disciplina: Presencial<\/p>\n

                        Bibliografia:<\/p>\n

                          \n
                        • Lundberg IE, Tj\u00e4rnlund A, Bottai M, Werth VP, Pilkington C, Visser M, Alfredsson L, Amato AA, Barohn RJ, Liang MH, Singh JA, Aggarwal R, Arnardottir S, Chinoy H, Cooper RG, Dank\u00f3 K, Dimachkie MM, Feldman BM, Torre IG, Gordon P, Hayashi T, Katz JD, Kohsaka H, Lachenbruch PA, Lang BA, Li Y, Oddis CV, Olesinska M, Reed AM, Rutkowska-Sak L, Sanner H, Selva-O’Callaghan A, Song YW, Vencovsky J, Ytterberg SR, Miller FW, Rider LG; International Myositis Classification Criteria Project consortium, The Euromyositis register and The Juvenile Dermatomyositis Cohort Biomarker Study and Repository (JDRG) (UK and Ireland). 2017 European League Against Rheumatism\/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. Ann Rheum Dis. 2017Dec;76(12):1955-1964.<\/li>\n
                        • Suzuki S, Uruha A, Suzuki N, Nishino I. Integrated Diagnosis Project for Inflammatory Myopathies: An association between autoantibodies and muscle pathology. Autoimmun Rev. 2017 Jul;16(7):693-700.<\/li>\n
                        • Selva-O’Callaghan A, Pinal-Fernandez I, Trallero-Aragu\u00e1s E, Milisenda JC, Grau-Junyent JM, Mammen AL. Classification and management of adult inflammatory
                          \nmyopathies. Lancet Neurol. 2018 Sep;17(9):816-828.<\/li>\n
                        • Miller FW, Lamb JA, Schmidt J, Nagaraju K. Risk factors and disease mechanisms in myositis. Nat Rev Rheumatol. 2018 Apr 20;14(5):255-268.<\/li>\n
                        • McHugh NJ, Tansley SL. Autoantibodies in myositis. Nat Rev Rheumatol. 2018 Apr 20;14(5):290-302.<\/li>\n
                        • Adler BL, Christopher-Stine L. Triggers of inflammatory myopathy: insights into pathogenesis. Discov Med. 2018 Feb;25(136):75-83.<\/li>\n
                        • Selva-O’Callaghan A, Alvarado-Cardenas M, Pinal-Fern\u00e1ndez I, Trallero-Aragu\u00e1s E, Milisenda JC, Mart\u00ednez M\u00c1, Mar\u00edn A, Labrador-Horrillo M, Ju\u00e1rez C, Grau-Junyent JM. Statin-induced myalgia and myositis: an update on pathogenesis and clinical recommendations. Expert Rev Clin Immunol. 2018 Mar;14(3):215-224.<\/li>\n
                        • Sena P, Gianatti A, Gambini D. Dermatomyositis: clinicopathological correlations. G Ital Dermatol Venereol. 2018 Apr;153(2):256-264.<\/li>\n
                        • Cavagna L, Casta\u00f1eda S, Scir\u00e9 C, Gonzalez-Gay MA; AENEAS Collaborative Group Members. Antisynthetase syndrome or what else? Different perspectives indicate the need for new classification criteria. Ann Rheum Dis. 2018 Aug;77(8):e50.<\/li>\n
                        • Correction: Idiopathic inflammatory myopathies: narrative review of unmet needs in clinical practice guidelines. RMD Open. 2019 Apr 15;5(1):e000784corr1. doi: 10.1136\/rmdopen-2018-000784corr1. Erratum for: RMD Open. 2019 Feb 26;4(Suppl 1):e000784.<\/li>\n
                        • Greenberg SA. Inclusion body myositis: clinical features and pathogenesis. Nat Rev Rheumatol. 2019 May;15(5):257-272.<\/li>\n
                        • Rietveld A, Lim J, de Visser M, van Engelen B, Pruijn G, Benveniste O, van der Kooi A, Saris C. Autoantibody testing in idiopathic inflammatory myopathies. Pract Neurol. 2019 Aug;19(4):284-294.<\/li>\n
                        • Cassius et al. Biomarkers in adult dermatomyositis; tools to help the diagnosis and predict the clinical outcome. J Immunol Res 2019.<\/li>\n
                        • Anquetil C, Boyer O, Wesner N, Benveniste O, Allenbach Y. Myositis-specific autoantibodies, a cornerstone in immune-mediated necrotizing myopathy. Autoimmun Rev. 2019 Mar;18(3):223-230.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
                          \n
                          <\/i><\/i>MOT5747 – SEMIN\u00c1RIOS EM CI\u00caNCIAS DO SISTEMA MUSCULOESQUEL\u00c9TICO<\/div>\n
                          \n

                          Sigla: MOT5747 \u2013 1
                          \nNome: Semin\u00e1rios em Ci\u00eancias do Sistema Musculoesquel\u00e9tico
                          \n\u00c1rea: Ci\u00eancias do Sistema Musculoesquel\u00e9tico (5140)<\/p>\n

                          Datas de aprova\u00e7\u00e3o:
                          \nCCP: 20\/05\/2019
                          \nCPG: 13\/06\/2019
                          \nCoPGr:
                          \nData de ativa\u00e7\u00e3o:13\/06\/2019
                          \nData de desativa\u00e7\u00e3o:<\/p>\n

                          Carga hor\u00e1ria:
                          \nTotal: 120 h
                          \nTe\u00f3rica:2 h
                          \nPr\u00e1tica: 0 h
                          \nEstudo: 6 h
                          \nCr\u00e9ditos:8
                          \nDura\u00e7\u00e3o:15 Semanas<\/p>\n

                          Respons\u00e1veis:
                          \n57150 – Eloisa Silva Dutra de Oliveira Bonfa – 13\/06\/2019 at\u00e9 data atual
                          \n3734237 – Marco Kawamura Demange – 13\/06\/2019 at\u00e9 data atual
                          \n4900112 – Bruno Gualano – 13\/06\/2019 at\u00e9 data atual<\/p>\n

                          Objetivos:
                          \nAprofundar o conhecimento e a integra\u00e7\u00e3o de pesquisadores e alunos interessados nas ci\u00eancias b\u00e1sicas e aplicadas associadas ao sistema musculoesquel\u00e9tico, com vistas ao desenvolvimento, \u00e0 expans\u00e3o e ao aprimoramento de projetos de pesquisa colaborativos, resultantes de uma intera\u00e7\u00e3o de pesquisadores e alunos com especialidades e interesses cient\u00edficos diversos, por\u00e9m potencialmente complementares.<\/p>\n

                          Justificativa:
                          \nAs ci\u00eancias do sistema musculoesquel\u00e9tico s\u00e3o amplas e heterog\u00eaneas, por\u00e9m podem apresentar converg\u00eancias e complementariedade, com respeito \u00e0s perguntas, abordagens e aos m\u00e9todos cient\u00edficos. A apresenta\u00e7\u00e3o e discuss\u00e3o de estudos cient\u00edficos que englogam essa grande \u00e1rea do conhecimento permitem detectar lacunas a serem exploradas na pesquisa, especialmente de modo colaborativo. A fun\u00e7\u00e3o desta disciplina \u00e9 oportunizar a intera\u00e7\u00e3o de alunos e pesquisadores de diversos campos do conhecimento que possuem, em comum, o interesse nas ci\u00eancias b\u00e1sicas e aplicadas atinentes ao sistema musculoesquel\u00e9tico.<\/p>\n

                          Conte\u00fado:
                          \nJovens e experientes pesquisadores com atua\u00e7\u00e3o nas ci\u00eancias do musculoesquel\u00e9tico apresentar\u00e3o seus estudos e discutir\u00e3o seus achados, com vistas \u00e0s possibilidades de colabora\u00e7\u00e3o. Os temas das palestras ser\u00e3o diversificados e cobrir\u00e3o da pesquisa b\u00e1sica \u00e0 cl\u00ednica, de modo a atender a complexidade e abrang\u00eancia das ci\u00eancias do sistema musculoesquel\u00e9tico, permitindo ao aluno uma vis\u00e3o ampla e integrativa da \u00e1rea. Notadamente, a cada edi\u00e7\u00e3o da Disciplina, os seguintes temas ser\u00e3o abordados: 1. Modelo para an\u00e1lise de les\u00f5es do sistema nervoso; 2. Desenvolvimento de ensaios e modelos para substitui\u00e7\u00e3o articular; 3. Ensaios sobre instabilidades articulares; 4. Dist\u00farbios degenerativos, inflamat\u00f3rios e estruturais do sistema locomotor; 5. Osteoimunologia e avalia\u00e7\u00e3o dos processos de regenera\u00e7\u00e3o musculoesquel\u00e9tica; 6. Modelos cl\u00ednicos e experimentais da an\u00e1lise funcional do movimento humano; 7. Sistema imune e autoimune; 8. Efeitos do exerc\u00edcio, nutri\u00e7\u00e3o e gen\u00e9tica na sa\u00fade e no desempenho f\u00edsico.<\/p>\n

                          Forma de avalia\u00e7\u00e3o:
                          \nOs alunos dever\u00e3o entregar resenhas cr\u00edticas referentes a cada apresenta\u00e7\u00e3o, a partir das quais se obter\u00e1 a avalia\u00e7\u00e3o final.<\/p>\n

                          Observa\u00e7\u00e3o:
                          \n\u00c9 recomend\u00e1vel o dom\u00ednio da l\u00edngua inglesa, pois algumas palestras ser\u00e3o ministradas nesse idioma.<\/p>\n

                          Tipo de oferecimento da disciplina: Presencial<\/p>\n

                          Bibliografia:<\/p>\n

                            \n
                          • Bonfa et al. Association between lupus psychosis and anti-ribosomal P protein antibodies. N Engl J Med. 1987 30;317(5):265-71.<\/li>\n
                          • Cristante et al. Therapeutic approaches for spinal cord injury. Clinics. 2012 67(10):1219-1224.<\/li>\n
                          • Gurgel et al. Acetabular component positioning in total hip arthroplasty with and without a computer-assisted system: a prospective, randomized and controlled study. J Arthroplasty. 2014 29(1):167-71.<\/li>\n
                          • Hinckel et al. Medial Patellofemoral Ligament, Medial Patellotibial Ligament, and Medial Patellomeniscal Ligament: Anatomic, Histologic, Radiographic, and Biomechanical Study. Arthroscopy. 2017 Oct;33(10):1862-1873.<\/li>\n
                          • Gracitelli et al. Locking intramedullary nails versus locking plates for the treatment of proximal humerus fractures. Expert Rev Med Devices. 2017 14(9):733-739.<\/li>\n
                          • Gualano et al. Physical activity for paediatric rheumatic diseases: standing up against old paradigms. Nat Rev Rheumatol. 2017 23;13(6):368-379.<\/li>\n
                          • Saunders et al. &#946;-alanine supplementation to improve exercise capacity and performance: a systematic review and meta-analysis. Br J Sports Med. 2017 51(8):658-669.<\/li>\n
                          • Malavolta et al. Clinical and Structural Evaluations of Rotator Cuff Repair With and Without Added Platelet-Rich Plasma at 5-Year Follow-up: A Prospective Randomized Study. Am J Sports Med. 2018 46(13):3134-3141.<\/li>\n
                          • Alvarenga et al. The relationship between estimated bone strength by finite element analysis at the peripheral skeleton to areal BMD and trabecular bone score at lumbar spine. Bone. 2018 117:47-53.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
                            \n
                            <\/i><\/i>MOT5748 – SIMPLIFICANDO A ESTAT\u00cdSTICA APLICADA NAS PESQUISAS M\u00c9DICAS E DA SA\u00daDE: UMA ABORDAGEM PASSO A PASSO<\/div>\n
                            \n

                            Sigla: MOT5748 – 1
                            \nNome: Simplificando a Estat\u00edstica Aplicada nas Pesquisas M\u00e9dicas e da Sa\u00fade: Uma abordagem Passo a Passo
                            \n\u00c1rea: Ci\u00eancias do Sistema Musculoesquel\u00e9tico (5140)<\/p>\n

                            Datas de aprova\u00e7\u00e3o:
                            \nCCP: 24\/07\/2019
                            \nCPG: 15\/08\/2019
                            \nCoPGr:
                            \nData de ativa\u00e7\u00e3o:15\/08\/2019
                            \nData de desativa\u00e7\u00e3o:<\/p>\n

                            Carga hor\u00e1ria:
                            \nTotal: 60 h
                            \nTe\u00f3rica:10 h
                            \nPr\u00e1tica: 10 h
                            \nEstudo: 10 h
                            \nCr\u00e9ditos:4
                            \nDura\u00e7\u00e3o:2 Semanas<\/p>\n

                            Respons\u00e1veis:
                            \n4900112 – Bruno Gualano – 15\/08\/2019 at\u00e9 data atual
                            \n9627350 – Eimear Bernadette Dolan – 15\/08\/2019 at\u00e9 data atual
                            \n11600107 – Paul Alan Swinton – 15\/08\/2019 at\u00e9 data atual<\/p>\n

                            Objetivos:
                            \nMelhorar a capacidade dos alunos de interpretar e avaliar abordagens de an\u00e1lise de dados comumente usadas em ci\u00eancias m\u00e9dicas e da sa\u00fade.<\/p>\n

                            Justificativa:
                            \nAppropriate statistical design and interpretation is fundamental in health and medical research. However, with increasing access to data from multiple sources and interest in novel research areas such as individual response to treatment, a more diverse range of data analysis approaches are being presented in health and medical research. As a result, much debate and controversy exists regarding which data analysis practices are effective and under what situations. The proposed discipline will educate students on the principles, limitations and applications of common data analysis approaches and practices. Underlying theoretical approaches will be contextualised using real data sets and exemplar peer-reviewed articles from seminal journals within the area. On completion of the course, students will be equipped with the knowledge and skills to interpret and critically evaluate a range of contemporary data analysis practices used within the Health and Medical Sciences.<\/p>\n

                            Conte\u00fado:
                            \nSer\u00e3o convidados especialistas em diferentes \u00e1reas de conhecimento do Metabolismo \u00d3sseo para discutir The course will comprise an intensive two-week long course. Theoretical topics to be covered include: basic rules of probability; randomization practices; sample size requirements; hypothesis testing; multiplicity problems; reliability; pooling evidence; quantifying effect size. Each of the topics will be contextualised using real data sets and contemporary applications of the theory (e.g. identification of responders vs. non-responders, identification of clinically meaningful changes, meta-analyses and the use of meta-regression, magnitude-based inferences). On completion, students will have a greater awareness of the assumptions that underpin contemporary data analysis approaches and be able to interpret and critically evaluate results generated. In addition, time will be dedicated to address specific statistical queries that the students have.<\/p>\n

                            Observa\u00e7\u00e3o:
                            \nOs alunos dever\u00e3o selecionar um t\u00f3pico de uma lista pr\u00e9-definida e preparar uma apresenta\u00e7\u00e3o de 15 minutos, na qual descrever\u00e3o criticamente a t\u00e9cnica escolhida junto com as teorias e suposi\u00e7\u00f5es que sustentam sua aplica\u00e7\u00e3o. Para tanto, ser\u00e3o fornecidos conjuntos de dados simulados e os alunos conduzir\u00e3o seu teste usando programa estat\u00edstico de livre escolha e, ent\u00e3o, descrever\u00e3o de modo cr\u00edtico seus resultados.<\/p>\n

                            OBSERVA\u00c7\u00d5ES: As aulas ser\u00e3o ministradas em ingl\u00eas.<\/p>\n

                            Tipo de oferecimento da disciplina: Presencial<\/p>\n

                            Bibliografia:<\/p>\n

                              \n
                            • Pagano, M. Gauvreau, K. Principles of Biostatistics (2018). 2nd edition. Chapman and Hall Swinscow, T. Statistics at square one (1997). BMJ Publishing Group.<\/li>\n
                            • https:\/\/www.bmj.com\/about-bmj\/resources-readers\/publications\/statistics-square-one Bland, M. Altman, D. Statistics Notes in the British Medical Journal: https:\/\/www-users.york.ac.uk\/~mb55\/pubs\/pbstnote.htm<\/li>\n
                            • Atkinson, G. Batterham, A.M. True and false interindividual differences in the physiological response to an intervention. Exp Physiol. 2015. 100(6): 577-88.<\/li>\n
                            • Swinton PA, Hemingway BS, Saunders B, Gualano B, Dolan E. A Statistical Framework to Interpret Individual Response to Intervention: Paving the Way for Personalized Nutrition and Exercise Prescription. Front Nutr. 2018 May 28;5:41.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
                              \n
                              <\/i><\/i>MOT5749 – PR\u00c1TICA DE REDA\u00c7\u00c3O DE ARTIGOS CIENT\u00cdFICOS NA CI\u00caNCIA DO EXERC\u00cdCIO<\/div>\n
                              \n

                              Sigla: MOT5749 – 1
                              \nNome: Pr\u00e1tica de Reda\u00e7\u00e3o de Artigos Cient\u00edficos na Ci\u00eancia do Exerc\u00edcio
                              \n\u00c1rea: Ci\u00eancias do Sistema Musculoesquel\u00e9tico (5140)<\/p>\n

                              Datas de aprova\u00e7\u00e3o:
                              \nCCP: 27\/09\/2019
                              \nCPG: 12\/12\/2019
                              \nCoPGr:
                              \nData de ativa\u00e7\u00e3o:12\/12\/2019
                              \nData de desativa\u00e7\u00e3o:<\/p>\n

                              Carga hor\u00e1ria:
                              \nTotal: 90 h
                              \nTe\u00f3rica:4 h
                              \nPr\u00e1tica:4 h
                              \nEstudo:10 h
                              \nCr\u00e9ditos:6
                              \nDura\u00e7\u00e3o:5 Semanas<\/p>\n

                              Respons\u00e1veis:
                              \n1056467 – Hamilton Augusto Roschel da Silva – 12\/12\/2019 at\u00e9 data atual
                              \n4900112 – Bruno Gualano – 12\/12\/2019 at\u00e9 data atual
                              \n8459733 – Bryan Saunders – 12\/12\/2019 at\u00e9 data atual<\/p>\n

                              Objetivos:
                              \nIntroduzir t\u00e9cnicas pr\u00e1ticas de reda\u00e7\u00e3o de artigos cient\u00edficos.<\/p>\n

                              Justificativa:
                              \nA boa reda\u00e7\u00e3o aumenta sobremaneira a aceita\u00e7\u00e3o, o impacto e a repercuss\u00e3o de artigos cient\u00edficos. T\u00e9cnicas de escrita que ser\u00e3o discutidas nesta discipina podem auxiliar os alunos da \u00e1rea de ci\u00eancia do exerc\u00edco a produzirem artigos de qualidade.<\/p>\n

                              Conte\u00fado:
                              \nEm aulas predominamente pr\u00e1ticas, os alunos ser\u00e3o treinados a redigirem os seguintes t\u00f3picos que comp\u00f5e um artigo cient\u00edfico (a) Introdu\u00e7\u00e3o (s\u00edntese da literatura, problema\/lacuna, objetivo e hip\u00f3tese); (b) M\u00e9todos (ordem de t\u00f3picos, desenho experimental, amostra, avalia\u00e7\u00f5es e an\u00e1lise estat\u00edsitca) e Resultados (op\u00e7\u00f5es em apresenta\u00e7\u00e3o de dados); (c) Discuss\u00e3o e Conclus\u00e3o (achados centrais, contraste dos dados com a literatura, limita\u00e7\u00f5es e mensagem final); (d) Resumo e Palavras-chave; (e) T\u00edtulo; (f) Conflito de interesses; (g) \u00abCover letter\u00bb (escolha do peri\u00f3dico como o primeiro passo e escolha de revisores e editores).<\/p>\n

                              Forma de avalia\u00e7\u00e3o:
                              \nOs alunos dever\u00e3o entregar um artigo cient\u00edfico completo produzido ao longo da disciplina. As t\u00e9cnicas de escrita praticadas nas aulas ser\u00e3o avaliadas.<\/p>\n

                              Observa\u00e7\u00e3o:
                              \n1) Por se tratar de uma disciplina pr\u00e1tica, ser\u00e3o aceitos 10 alunos no m\u00e1ximo.
                              \n2) Os alunos dever\u00e3o trazer dados de pesquisa coletados e analisados, preferencialmente n\u00e3o publicados, para serem utilizados nas aulas pr\u00e1ticas.
                              \n3) \u00c9 altamente recomend\u00e1vel o dom\u00ednio do idioma ingl\u00eas, pois os artigos ser\u00e3o produzidos nessa l\u00edngua.<\/p>\n

                              Tipo de oferecimento da disciplina: Presencial<\/p>\n

                              Bibliografia:<\/p>\n

                                \n
                              • von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP; STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)statement: guidelines for reporting observational studies. Lancet. 2007 Oct 20;370(9596):1453-7.<\/li>\n
                              • Tong A, Sainsbury P, Craig J. Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Int J Qual Health Care. 2007;19(6):349-357.<\/li>\n
                              • Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. Ann Intern Med. 2009;151(4):264-269, W64.<\/li>\n
                              • Schulz KF, Altman DG, Moher D, for the CONSORT Group. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. Ann Int Med 2010;152.<\/li>\n
                              • Gagnier JJ, Kienle G, Altman DA, Moher D, Sox H, Riley D; the CARE Group. The CARE Guidelines: Consensus-based Clinical Case Reporting Guideline Development. BMJ Case Rep. 2013; Oct 23;2013. pii: bcr2013201554.<\/li>\n
                              • Matthews JR and Matthews RW. Successful Scientific Writing: A Step-by-Step Guide for the Biological and Medical Sciences. Cambridge University Press. 4\u00aa Edi\u00e7\u00e3o. 2014.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
                                \n
                                <\/i><\/i>MOT5750 – FISIOLOGIA DA FADIGA MUSCULAR DURANTE O EXERC\u00cdCIO F\u00cdSICO<\/div>\n
                                \n

                                Sigla: MOT5750 – 1
                                \nNome: Fisiologia da Fadiga Muscular Durante o Exerc\u00edcio F\u00edsico
                                \n\u00c1rea: Ci\u00eancias do Sistema Musculoesquel\u00e9tico (5140)<\/p>\n

                                Datas de aprova\u00e7\u00e3o:
                                \nCCP: 12\/06\/2020
                                \nCPG: 12\/06\/2020
                                \nCoPGr:
                                \nData de ativa\u00e7\u00e3o: 12\/06\/2020
                                \nData de desativa\u00e7\u00e3o:<\/p>\n

                                Carga hor\u00e1ria:
                                \nTotal: 60 h
                                \nTe\u00f3rica:1 h
                                \nPr\u00e1tica:3 h
                                \nEstudo:6 h
                                \nCr\u00e9ditos:4
                                \nDura\u00e7\u00e3o:6 Semanas<\/p>\n

                                Respons\u00e1veis:
                                \n3442405 – Guilherme Giannini Artioli – 12\/06\/2020 at\u00e9 data atual
                                \n9470443 – L\u00edvia de Souza Gon\u00e7alves – 12\/06\/2020 at\u00e9 data atual<\/p>\n

                                Objetivos:
                                \nApresentar e discutir de forma cr\u00edtica e aprofundada os modelos te\u00f3ricos que explicam as origens da fadiga em diferentes tipos de exerc\u00edcio, bem como apresentar e discutir evid\u00eancias experimentais que apoiam e refutam esses modelos.<\/p>\n

                                Justificativa:
                                \nA fadiga muscular \u00e9 um dos fen\u00f4menos de mais import\u00e2ncia para o esporte e exerc\u00edcio, \u00e0 medida em que \u00e9 limitante majorit\u00e1rio do desempenho f\u00edsico. Por ser um fen\u00f4meno altamente complexo, multifatorial e que se manifesta por diferentes meios em diferentes tipos de exerc\u00edcio, sua compreens\u00e3o ainda \u00e9 de certa forma limitada. Ainda assim, a ci\u00eancia avn\u00e7ou sobremaneira no entendimento das diferentes formas da fadiga, bem como nos seus multiplos mecanismos causadores. A proposta desta disciplina \u00e9 abordar, de forma abrangente e aprofundada, as m\u00faltiplas causas da fadiga, em quais tipos de exerc\u00edcio elas se manifestam e cumprem papel relevante, al\u00e9m dos modelos te\u00f3ricos sobre fadiga.<\/p>\n

                                Conte\u00fado:
                                \n1. Defini\u00e7\u00f5es de fadiga
                                \n2. Tipos de fadiga
                                \n3. Modelos de estudo da fadiga
                                \n4. Mecanismos de fadiga perif\u00e9rica
                                \n5. Mecanismos de fadiga central
                                \n6. Modelos te\u00f3ricos de fadiga
                                \nForma de avalia\u00e7\u00e3o:
                                \nSemin\u00e1rios (30%) e trabalho escrito a ser entregue ao fim da disciplina (70%).
                                \nPresen\u00e7a obrigat\u00f3ria: 75%<\/p>\n

                                Observa\u00e7\u00e3o:
                                \nN\u00famero de alunos:<\/p>\n

                                M\u00ednimo: 5 alunos
                                \nM\u00e1ximo: 20 alunos
                                \nEspeciais: 3 alunos<\/p>\n

                                Tipo de oferecimento da disciplina: Presencial<\/p>\n

                                Bibliografia:<\/p>\n

                                  \n
                                • Fitts RH. Cellular mechanisms of muscle fatigue. Physiol Rev. 1994 Jan;74(1):49-94.<\/li>\n
                                • Green HJ. Mechanisms of muscle fatigue in intense exercise. J Sports Sci. 1997 Jun;15(3):247-56.<\/li>\n
                                • D G Allen and H Westerblad. Role of phosphate and calcium stores in muscle fatigue. J Physiol. 2001 Nov 1; 536(Pt 3): 657\u2013665.<\/li>\n
                                • H\u00e5kan Westerblad et al. Muscle Fatigue: Lactic Acid or Inorganic Phosphate the Major Cause? 2002 https:\/\/doi.org\/10.1152\/physiologyonline.2002.17.1.17.<\/li>\n
                                • Noakes et al. From catastrophe to complexity: a novel model of integrative central neural regulation of effort and fatigue during exercise in humans. British Journal of Sports Medicine 2004;38:511-514.<\/li>\n
                                • Noakes, T.D. The Central Governor Model of Exercise Regulation Applied to the Marathon. Sports Med (2007) 37: 374.<\/li>\n
                                • Nybo L. Hyperthermia and fatigue. J Appl Physiol (1985). 2008 Mar;104(3):871-8.<\/li>\n
                                • Allen DG, Lamb GD, Westerblad H. Skeletal muscle fatigue: cellular mechanisms. Physiol Rev. 2008 Jan;88(1):287-332.<\/li>\n
                                • Fitts RH. The cross-bridge cycle and skeletal muscle fatigue. J Appl Physiol (1985). 2008 Feb;104(2):551-8.
                                  \nMatsui T, Soya S, Okamoto M, Ichitani Y, Kawanaka K, Soya H. Brain glycogen decreases during prolonged exercise. J Physiol. 2011 Jul 1;589(Pt 13):3383-93.<\/li>\n
                                • Edward P. Debold. Recent Insights into Muscle Fatigue at the Cross-Bridge Level. Front Physiol. 2012; 3: 151.<\/li>\n
                                • Niels \u00d8rtenblad et al. Muscle glycogen stores and fatigue. J Physiol. 2013 Sep 15; 591(Pt 18): 4405\u20134413.<\/li>\n
                                • Nelson CR, Debold EP, Fitts RH. Phosphate and acidosis act synergistically to depress peak power in rat muscle fibers. Am J Physiol Cell Physiol. 2014 Nov 15;307(10):C939-50.<\/li>\n
                                • Debold EP. Potential molecular mechanisms underlying muscle fatigue mediated by reactive oxygen and nitrogen species. Front Physiol. 2015 Sep 1;6:239.<\/li>\n
                                • Debold EP. Decreased Myofilament Calcium Sensitivity Plays a Significant Role in Muscle Fatigue. Exerc Sport Sci Rev. 2016 Oct;44(4):144-9.<\/li>\n
                                • Debold EP et al. Muscle Fatigue from the Perspective of a Single Crossbridge. Med Sci Sports Exerc. 2016 Nov;48(11):2270-2280.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
                                  \n
                                  <\/i><\/i>MOT5751 – NUTRI\u00c7\u00c3O ESPORTIVA E EXERC\u00cdCIO: JOURNAL CLUB<\/div>\n
                                  \n

                                  Sigla: MOT5751 – 2
                                  \nNome: Nutri\u00e7\u00e3o Esportiva e Exerc\u00edcio: Journal Club
                                  \n\u00c1rea: Ci\u00eancias do Sistema Musculoesquel\u00e9tico (5140)<\/p>\n

                                  Datas de aprova\u00e7\u00e3o:
                                  \nCCP: 18\/08\/2021
                                  \nCPG: 14\/10\/2021
                                  \nCoPGr:
                                  \nData de ativa\u00e7\u00e3o: 14\/10\/2021
                                  \nData de desativa\u00e7\u00e3o:<\/p>\n

                                  Carga hor\u00e1ria:
                                  \nTotal: 90 h
                                  \nTe\u00f3rica:1 h
                                  \nPr\u00e1tica:2 h
                                  \nEstudo:7 h
                                  \nCr\u00e9ditos:6
                                  \nDura\u00e7\u00e3o:9 Semanas<\/p>\n

                                  Respons\u00e1veis:
                                  \n3112682 – Fabiana Braga Benatti – 14\/10\/2021 at\u00e9 data atual
                                  \n4900112 – Bruno Gualano – 14\/10\/2021 at\u00e9 data atual
                                  \n8459733 – Bryan Saunders – 14\/10\/2021 at\u00e9 data atual
                                  \n9627350 – Eimear Bernadette Dolan – 14\/10\/2021 at\u00e9 data atual<\/p>\n

                                  Objetivos:
                                  \nPromover um modo cr\u00edtico-cient\u00edfico de pensar e a analisar sobre um artigo cientifico, que \u00e9 essencial para o desenvolvimento dos alunos.<\/p>\n

                                  Justificativa:
                                  \nNutri\u00e7\u00e3o esportiva \u00e9 uma das disciplinas de mais r\u00e1pido crescimento e evolu\u00e7\u00e3o da ci\u00eancia do esporte e do exerc\u00edcio, demonstrada por um aumento de 4 vezes no n\u00famero de trabalhos publicados entre 2012 e 2018. Para o praticante de nutri\u00e7\u00e3o esportiva, o objetivo \u00e9 traduzir inova\u00e7\u00f5es em pesquisa para desenvolver e administrar interven\u00e7\u00f5es pr\u00e1ticas que contribuam para a entrega de performances vencedoras. Portanto, \u00e9 fundamental que haja compreens\u00e3o da qualidade de um artigo, e da traduzibilidade dos resultados para a pr\u00e1tica aplicada. Ao concluir o curso, os alunos possuir\u00e3o conhecimento e habilidades para interpretar e avaliar criticamente pesquisas na \u00e1rea de nutri\u00e7\u00e3o esportiva.<\/p>\n

                                  Conte\u00fado:
                                  \nNesta disciplina, os alunos dever\u00e3o ler artigos de peri\u00f3dicos cient\u00edficos escritos em ingl\u00eas na \u00e1rea de nutri\u00e7\u00e3o esportiva, preparar apresenta\u00e7\u00f5es curtas e pontos de discuss\u00e3o e, finalmente, apresentar os artigos escolhidos e suas descobertas e conduzir uma discuss\u00e3o sobre o t\u00f3pico. Os alunos aprender\u00e3o como avaliar criticamente os principais aspectos desses artigos usando a lista de verifica\u00e7\u00e3o PRESENT (Betts et al., 2020), enquanto avaliam a traduzibilidade para a pr\u00e1tica do mundo real dos resultados usando diretrizes (Close et al., 2019).
                                  \nAs sess\u00f5es seriam realizadas em ingl\u00eas, que \u00e9 a l\u00edngua da ci\u00eancia, paraj ajudar diminuir e superar as dificuldades que falantes n\u00e3o-nativos podem ter com a leitura, fala e a escrita em ingl\u00eas. O Journal Club ter\u00e1 um ambiente que possibilitara a pratica dessas habilidades, portanto, a disciplina ir\u00e1 incorporar o m\u00e1ximo de falar ingl\u00eas nas sess\u00f5es para promover uma melhor compreens\u00e3o e preparar os alunos para processos de internacionaliza\u00e7\u00e3o, carreira acad\u00eamica e consumo de literatura cientifica. A apresenta\u00e7\u00e3o em ingl\u00eas seria obrigat\u00f3ria enquanto pontos de discuss\u00e3o poderiam ser feitos em portugu\u00eas quando necess\u00e1rio para promover a participa\u00e7\u00e3o, e assim, promover um modo cr\u00edtico-cient\u00edfico de pensar e a analisar, que \u00e9 crucial para o seu desenvolvimento dos alunos. Um exame final exigir\u00e1 que os alunos selecionem um artigo original de sua escolha na \u00e1rea de Nutri\u00e7\u00e3o Esportiva e preparem uma apresenta\u00e7\u00e3o de 15 minutos, onde far\u00e3o uma avalia\u00e7\u00e3o cr\u00edtica do manuscrito usando as ferramentas que adquiriram durante o curso.
                                  \nForma de avalia\u00e7\u00e3o:
                                  \nOs alunos ir\u00e3o selecionar um artigo original de sua escolha na \u00e1rea de Nutri\u00e7\u00e3o Esportiva e Exerc\u00edcio, e preparar uma apresenta\u00e7\u00e3o de 15 minutos, onde far\u00e3o uma avalia\u00e7\u00e3o cr\u00edtica do manuscrito usando as ferramentas que adquiriram durante o curso.<\/p>\n

                                  PRESEN\u00c7A OBRIGAT\u00d3RIA: 80%<\/p>\n

                                  Observa\u00e7\u00e3o:
                                  \nAs aulas ser\u00e3o ministradas em ingl\u00eas.<\/p>\n

                                  N\u00famero de alunos: 20
                                  \nM\u00ednimo: 8
                                  \nM\u00e1ximo: 20<\/p>\n

                                  Tipo de oferecimento da disciplina: Presencial<\/p>\n

                                  Bibliografia:<\/p>\n

                                    \n
                                  • Bergstrom, J., Hermansen, L., Hultman, E., & Saltin, B. (1967). Diet, muscle glycogen and physical performance. Acta Physiologica Scandinavica, 71(2), 140-150. doi: 10.1111\/j.1748-1716.1967.tb03720.x.<\/li>\n
                                  • Harris, R. C., Soderlund, K., & Hultman, E. (1992). Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clinical Science, 83(3), 367-374.<\/li>\n
                                  • Harris, R. C., Tallon, M. J., Dunnett, M., Boobis, L., Coakley, J., Kim, H. J., Wise, J. A. (2006). The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids, 30(3), 279-289. doi: 10.1007\/s00726-006-0299-9<\/li>\n
                                  • Close, G. L., Kasper, A. M., & Morton, J. P. (2019). From Paper to Podium: Quantifying the Translational Potential of Performance Nutrition Research. Sports Medicine, 49(Suppl 1), 25-37. doi: 10.1007\/s40279-018-1005-2<\/li>\n
                                  • Betts, J. A., Gonzalez, J. T., Burke, L. M., Close, G. L., Garthe, I., James, L. J., Atkinson, G. (2020). PRESENT 2020: Text Expanding on the Checklist for Proper Reporting of Evidence in Sport and Exercise Nutrition Trials. International Journal of Sport Nutrition and Exercise Metabolism, 1-12. doi: 10.1123\/ijsnem.2019-0326<\/li>\n
                                  • Jensen, R., Ortenblad, N., Stausholm, M. H., Skjaerbaek, M. C., Larsen, D. N., Hansen, M., Nielsen, J. (2020). Heterogeneity in subcellular muscle glycogen utilisation during exercise impacts endurance capacity in men. The Journal of Physiology. doi: 10.1113\/JP280247<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
                                    \n
                                    <\/i><\/i>MOT5752 – ORTOGERIATRIA – CONSTRU\u00c7\u00c3O CR\u00cdTICA: DO METABOLISMO \u00c0 SA\u00daDE P\u00daBLICA<\/div>\n
                                    \n

                                    Sigla: MOT5752 – 1
                                    \nNome: Ortogeriatria – Constru\u00e7\u00e3o Cr\u00edtica: do Metabolismo \u00e0 Sa\u00fade P\u00fablica
                                    \n\u00c1rea: Ci\u00eancias do Sistema Musculoesquel\u00e9tico (5140)<\/p>\n

                                    Datas de aprova\u00e7\u00e3o:
                                    \nCCP: 18\/01\/2021
                                    \nCPG: 11\/03\/2021
                                    \nCoPGr:
                                    \nData de ativa\u00e7\u00e3o: 11\/03\/2021
                                    \nData de desativa\u00e7\u00e3o:<\/p>\n

                                    Carga hor\u00e1ria:
                                    \nTotal: 120 h
                                    \nTe\u00f3rica:2 h
                                    \nPr\u00e1tica:2 h
                                    \nEstudo:6 h
                                    \nCr\u00e9ditos:8
                                    \nDura\u00e7\u00e3o:12 Semanas<\/p>\n

                                    Respons\u00e1veis:
                                    \n955902 – Luiz Eugenio Garcez Leme – 11\/03\/2021 at\u00e9 data atual<\/p>\n

                                    Objetivos:
                                    \nFormar corpo de conhecimento integrado que permita aos docentes e pesquisadores interessados na \u00e1rea do envelhecimento do aparelho locomotor e seu impacto na sa\u00fade individual e coletiva; desenvolver grupos de ensino e pesquisa na \u00e1rea, ainda insuficientemente representada em nosso meio, bem como o desenvolvimento de grupos de interven\u00e7\u00e3o ortogeri\u00e1trica com abordagem de assist\u00eancia interprofissional compartilhada em condi\u00e7\u00f5es de acompanhar de maneira cr\u00edtica este tipo espec\u00edfico da interven\u00e7\u00e3o.<\/p>\n

                                    Justificativa:
                                    \nO r\u00e1pido envelhecimento populacional brasileiro, acompanhado, diferentemente de outros pa\u00edses, de limita\u00e7\u00f5es materiais crescentes, reflete-se em uma s\u00e9rie de afec\u00e7\u00f5es de sa\u00fade ligadas \u00e0s limita\u00e7\u00f5es funcionais e \u00e0 fragilidade caracter\u00edsticas deste grupo et\u00e1rio. As limita\u00e7\u00f5es cr\u00f4nicas e agudas do aparelho locomotor com perda de autonomia e traumas assumem a\u00ed sua mais perversa manifesta\u00e7\u00e3o com perdas funcionais, de qualidade de vida e custos crescentes com alto impacto na sa\u00fade individual e na sa\u00fade p\u00fablica. A Ortogeriatria assume este tipo de estudo e interven\u00e7\u00e3o, atrav\u00e9s de m\u00e9todos peculiares de aten\u00e7\u00e3o \u00e0 pessoa fr\u00e1gil e multi-comprometida, procurando preservar sua funcionalidade e qualidade de vida. Este tipo de conhecimento, j\u00e1 existente em grande parte do mundo, teve seu in\u00edcio nos anos 50 do s\u00e9culo XX, com maior desenvolvimento nos \u00faltimos 20 anos; no entanto em nosso meio seu desenvolvimento ainda \u00e9 insuficiente. O Grupo de Ortogeriatria do IOTHCFMUSP foi, em nosso meio, o primeiro a abordar este tema desde 1997, sendo durante muitos anos o \u00fanico grupo brasileiro, ainda sendo um dos muito poucos com este tipo de foco. Desta forma este tipo de disciplina justifica-se na estrat\u00e9gia do desenvolvimento das \u00e1reas de pesquisa, ensino e assist\u00eancia da Ortogeriatria em nosso meio, acorde com os princ\u00edpios da Universidade de S\u00e3o Paulo.<\/p>\n

                                    Conte\u00fado:
                                    \nBlocos tem\u00e1ticos:
                                    \nA disciplina ser\u00e1 desenvolvida a partir de quatro blocos tem\u00e1ticos onde se inserem as reuni\u00f5es:
                                    \nEnvelhecimento locomotor e fragilidade \u2013 Osteosarcopenia
                                    \nOrtogeriatria e Sa\u00fade P\u00fablica \u2013 Limita\u00e7\u00f5es funcionais, traumas, fraturas, preven\u00e7\u00e3o em seus n\u00edveis. Cria\u00e7\u00e3o de protocolos, estruturas internacionais.
                                    \nAbordagem do idoso traumatizado: Peri-operat\u00f3rio, cuidado interprofissional. Abordagens integradas, cuidados paliativos.
                                    \nPlanejamento de sa\u00fade coletiva em ortogeriatria.<\/p>\n

                                    Crit\u00e9rios de avalia\u00e7\u00e3o:
                                    \nFrequ\u00eancia e participa\u00e7\u00e3o nas atividades.
                                    \nApresenta\u00e7\u00e3o de texto ou trabalho de conclus\u00e3o na forma de:
                                    \nProjeto de pesquisa ou Revis\u00e3o sobre o tema ou Projeto de implanta\u00e7\u00e3o de servi\u00e7o ou grupo de aten\u00e7\u00e3o em Ortogeriatria<\/p>\n

                                    70 % de frequ\u00eancia nas aulas<\/p>\n

                                    N\u00ba. m\u00ednimo de alunos= 3 alunos; N\u00ba. m\u00e1ximo de alunos=12; Especiais: 4<\/p>\n

                                    Observa\u00e7\u00f5es:
                                    \nTodas as atividades da disciplina (aulas, conferencias, semin\u00e1rios, apresenta\u00e7\u00f5es) poder\u00e3o ser realizadas na forma presencial ou por teleconfer\u00eancia, notadamente aquelas que t\u00eam participa\u00e7\u00e3o de conferencistas internacionais.
                                    \nAs apresenta\u00e7\u00f5es\/discuss\u00f5es, dependendo dos apresentadores, poder\u00e3o ser feitas em l\u00edngua inglesa ou espanhola, al\u00e9m da l\u00edngua portuguesa.<\/p>\n

                                    Tipo de oferecimento da disciplina: Presencial<\/p>\n

                                    Bibliografia:<\/p>\n

                                      \n
                                    • MACHADO, ABC; EASTELL, R. Clinical Application of Biochemical Markers of Bone Turnover in Osteoporosis. CME. Premium-Fortbildung f\u00fcr die medizinische Praxis \/ Continuing Medical Education, v. 1, p. 1, 1998.<\/li>\n
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                                    • Pilotto A, Custodero C, Maggi S, Polidori MC, Veronese N, Ferrucci L. A multidimensional approach to frailty in older people. Ageing Res Rev. 2020 Jul; 60:101047. doi: 10.1016\/j.arr.2020.101047. Epub 2020 Mar 21. PMID: 32171786; PMCID: PMC7461697.<\/li>\n
                                    • Ranhoff AH. Orthogeriatrics: much more action is needed. Eur Geriatr Med. 2020 Aug;11(4):517-518. doi: 10.1007\/s41999-020-00375-2. PMID: 32779006; PMCID: PMC7416800.<\/li>\n
                                    • Rapp K, Becker C, Todd C, Rothenbacher D, Schulz C, K\u00f6nig HH, Liener U, Hartwig E, B\u00fcchele G. The Association Between Orthogeriatric Co-Management and Mortality Following Hip Fracture. Dtsch Arztebl Int. 2020 Jan 24;117(4):53-59. doi: 10.3238\/arztebl.2020.0053. PMID: 32036854; PMCID: PMC7036469.<\/li>\n
                                    • S\u00e1nchez-Castellano C, Mart\u00edn-Arag\u00f3n S, Bermejo-Besc\u00f3s P, Vaquero-Pinto N, Miret-Corchado C, Merello de Miguel A, Cruz-Jentoft AJ. Biomarkers of sarcopenia in very old patients with hip fracture. J Cachexia Sarcopenia Muscle. 2020 Apr;11(2):478-486. doi: 10.1002\/jcsm.12508. Epub 2020 Jan 8. PMID: 31912666; PMCID: PMC7113494.<\/li>\n
                                    • Sep\u00falveda-Loyola W, Osadnik C, Phu S, Morita AA, Duque G, Probst VS. Diagnosis, prevalence, and clinical impact of sarcopenia in COPD: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 2020 Oct;11(5):1164-1176. doi: 10.1002\/jcsm.12600. Epub 2020 Aug 30. PMID: 32862514; PMCID: PMC7567149.<\/li>\n
                                    • Talevski J, Guerrero-Cede\u00f1o V, Demontiero O, Suriyaarachchi P, Boersma D, Vogrin S, Brennan-Olsen S, Duque G. Implementation of an electronic care pathway for hip fracture patients: a pilot before and after study. BMC Musculoskelet Disord. 2020 Dec 11;21(1):837. doi: 10.1186\/s12891-020-03834-w. PMID: 33308200; PMCID: PMC7731480.<\/li>\n
                                    • Werner M, Krause O, Macke C, Herold L, Ranker A, Krettek C, Liodakis E. Orthogeriatric co-management for proximal femoral fractures. Can two additions make a big difference? BMC Musculoskelet Disord. 2020 Jun 11;21(1):371. doi: 10.1186\/s12891-020-03392-1. PMID: 32527237; PMCID: PMC7291750.<\/li>\n
                                    • Pioli G, Bendini C, Pignedoli P. Post-operative Management. 2020 Aug 21. In: Falaschi P, Marsh D, editors. Orthogeriatrics: The Management of Older Patients with Fragility Fractures [Internet]. Cham (CH): Springer; 2021. Chapter 11. PMID: 33347215.<\/li>\n
                                    • Marsh D, Mitchell P, Falaschi P, Beaupre L, Magaziner J, Seymour H, Costa M. The Multidisciplinary Approach to Fragility Fractures Around the World: Na Overview. 2020 Aug 21. In: Falaschi P, Marsh D, editors. Orthogeriatrics: The Management of Older Patients with Fragility Fractures [Internet]. Cham (CH): Springer; 2021. Chapter 1. PMID: 33347230.<\/li>\n
                                    • Dyer SM, Perracini MR, Smith T, Fairhall NJ, Cameron ID, Sherrington C, Crotty M. Rehabilitation Following Hip Fracture. 2020 Aug 21. In: Falaschi P, Marsh D, editors. Orthogeriatrics: The Management of Older Patients with Fragility Fractures [Internet]. Cham (CH): Springer; 2021. Chapter 12. PMID: 33347227.<\/li>\n
                                    • Eleuteri S, de Lima MEB, Falaschi P. The Psychological Health of Patients and their Caregivers. 2020 Aug 21. In: Falaschi P, Marsh D, editors. Orthogeriatrics: The Management of Older Patients with Fragility Fractures [Internet]. Cham (CH): Springer; 2021. Chapter 13. PMID: 33347217.<\/li>\n
                                    • Blain H, Miot S, Bernard PL. How Can We Prevent Falls? 2020 Aug 21. In: Falaschi P, Marsh D, editors. Orthogeriatrics: The Management of Older Patients with Fragility Fractures [Internet]. Cham (CH): Springer; 2021. Chapter 16. PMID: 33347226.<\/li>\n
                                    • Marsh D, Mitchell P, Falaschi P, Beaupre L, Magaziner J, Seymour H, Costa M. The Multidisciplinary Approach to Fragility Fractures Around the World: Na Overview. 2020 Aug 21. In: Falaschi P, Marsh D, editors. Orthogeriatrics: The Management of Older Patients with Fragility Fractures [Internet]. Cham (CH): Springer; 2021. Chapter 1. PMID: 33347230.<\/li>\n
                                    • Martin FC, Ranhoff AH. Frailty and Sarcopenia. 2020 Aug 21. In: Falaschi P, Marsh D, editors. Orthogeriatrics: The Management of Older Patients with Fragility Fractures [Internet]. Cham (CH): Springer; 2021. Chapter 4. PMID: 33347228.<\/li>\n
                                    • Ojeda-Thies C, Brent L, Currie CT, Costa M. Fragility Fracture Audit. 2020 Aug 21. In: Falaschi P, Marsh D, editors. Orthogeriatrics: The Management of Older Patients with Fragility Fractures [Internet]. Cham (CH): Springer; 2021. Chapter 19. PMID: 33347218.<\/li>\n
                                    • Ong T, Sahota O. Establishing an Orthogeriatric Service. 2020 Aug 21. In: Falaschi P, Marsh D, editors. Orthogeriatrics: The Management of Older Patients with Fragility Fractures [Internet]. Cham (CH): Springer; 2021. Chapter 5. PMID: 33347221.<\/li>\n
                                    • Tafaro L, Napoli N. Current and Emerging Treatment of Osteoporosis. 2020 Aug 21. In: Falaschi P, Marsh D, editors. Orthogeriatrics: The Management of Older Patients with Fragility Fractures [Internet]. Cham (CH): Springer; 2021. Chapter 15. PMID: 33347216.<\/li>\n
                                    • White SM. Orthogeriatric Anaesthesia. 2020 Aug 21. In: Falaschi P, Marsh D, editors. Orthogeriatrics: The Management of Older Patients with Fragility Fractures [Internet]. Cham (CH): Springer; 2021. Chapter 8. PMID: 33347233.<\/li>\n
                                    • Wilson H, Mayor A. Pre-operative Medical Assessment and Optimisation. 2020 Aug 21. In: Falaschi P, Marsh D, editors. Orthogeriatrics: The Management of Older Patients with Fragility Fractures [Internet]. Cham (CH): Springer; 2021. Chapter 7. PMID: 33347232.<\/li>\n<\/ul>\n

                                      <\/div<\/p>\n<\/div>\n

                                      \n
                                      <\/i><\/i>MOT5753 – BIOINFORM\u00c1TICA E SUAS APLICA\u00c7\u00d5ES EM DIVERSAS ESPECIALIDADES DE MEDICINA<\/div>\n
                                      \n

                                      Sigla: MOT5753 – 1
                                      \nNome: Bioinform\u00e1tica e suas Aplica\u00e7\u00f5es em Diversas Especialidades de Medicina
                                      \n\u00c1rea: Ci\u00eancias do Sistema Musculoesquel\u00e9tico (5140)<\/p>\n

                                      Datas de aprova\u00e7\u00e3o:
                                      \nCCP: 07\/07\/2021
                                      \nCPG: 09\/09\/2021
                                      \nCoPGr:
                                      \nData de ativa\u00e7\u00e3o: 09\/09\/2021<\/p>\n

                                      Carga hor\u00e1ria:
                                      \nTotal: 75 h
                                      \nTe\u00f3rica:5 h
                                      \nPr\u00e1tica:3 h
                                      \nEstudo:7 h
                                      \nCr\u00e9ditos:5
                                      \nDura\u00e7\u00e3o:5 Semanas<\/p>\n

                                      Respons\u00e1veis:
                                      \n1690250 – Rosa Maria Rodrigues Pereira – 09\/09\/2021 at\u00e9 data atual
                                      \n12430322 – Bidossessi Wilfried Hounkpe – 09\/09\/2021 at\u00e9 data atual<\/p>\n

                                      Objetivos:
                                      \nA disciplina tem como objetivo apresentar conhecimentos b\u00e1sicos da bioinform\u00e1tica e discutir suas aplica\u00e7\u00f5es na \u00e1rea m\u00e9dica.<\/p>\n

                                      Justificativa:
                                      \nA publica\u00e7\u00e3o da primeira vers\u00e3o do genoma humano tem levado a grandes avan\u00e7os em ci\u00eancias biom\u00e9dicas e ao desenvolvimento da bioinform\u00e1tica. Na era p\u00f3s gen\u00f4mica, a bioinform\u00e1tica vem ganhando cada vez mais import\u00e2ncia na avalia\u00e7\u00e3o dos mecanismos moleculares e vias de regula\u00e7\u00e3o associados \u00e0 patog\u00eanese de doen\u00e7as complexas, na descoberta de novos biomarcadores e na busca de novos tratamentos inovadores. Recentemente, este campo de conhecimento multidisciplinar auxiliou n\u00e3o somente no desenvolvimento das ci\u00eancias \u00f4micas mas tamb\u00e9m no diagn\u00f3stico e no progn\u00f3stico dos pacientes em v\u00e1rias especialidades m\u00e9dicas, abrindo o caminho para a medicina de precis\u00e3o. Portanto, o conhecimento das aplica\u00e7\u00f5es dessa \u00e1rea torna-se importante na forma\u00e7\u00e3o do pesquisador, m\u00e9dico em diversos campos da medicina.<\/p>\n

                                      Conte\u00fado:
                                      \nSer\u00e3o ministradas aulas te\u00f3ricas seguidas de aulas pr\u00e1ticas e\/ou estudos guiados para discutir os temas atuais da bioinform\u00e1tica enfatizando suas aplica\u00e7\u00f5es na \u00e1rea m\u00e9dica. Os estudos guiados ser\u00e3o apresentados para expor os alunos a alguns m\u00e9todos da bioinform\u00e1tica que t\u00eam um potencial inovador na \u00e1rea m\u00e9dica.
                                      \n1. Introdu\u00e7\u00e3o \u00e0 bioinform\u00e1tica (diferentes campos de conhecimento, ci\u00eancias \u00f4micas, microarray e t\u00e9cnicas de sequenciamento, bancos de dados de interesse na \u00e1rea m\u00e9dica)
                                      \n2. Ferramentas usadas no processamento de dados em bioinform\u00e1tica (ferramentas baseadas na web, linguagens de programa\u00e7\u00e3o, descoberta do R program)
                                      \n3. Gen\u00f4mica (Genoma, muta\u00e7\u00f5es patog\u00e9nicas, estudos gen\u00e9ticos, biopsia l\u00edquida)
                                      \n4. Transcript\u00f4mica (transcriptoma, avalia\u00e7\u00e3o de genes diferencialmente expressos, redes de sinaliza\u00e7\u00e3o e de regula\u00e7\u00e3o g\u00eanica, busca de biomarcadores)
                                      \n5. Aprendizado de m\u00e1quina e deep learning (M\u00e9todos computacionais, modelo preditivo, classifica\u00e7\u00e3o de pacientes usando dados cl\u00ednicos e de express\u00e3o g\u00eanico, diagn\u00f3stico por imagem)
                                      \nForma de avalia\u00e7\u00e3o:
                                      \nA avalia\u00e7\u00e3o do aluno ser\u00e1 realizada por meio de entrega de um relat\u00f3rio relacionado \u00e0s aulas ministradas, no final do curso. Para ser aprovado \u00e9 necess\u00e1ria a presen\u00e7a em 75% das aulas.<\/p>\n

                                      Observa\u00e7\u00e3o:
                                      \nN\u00famero de alunos: M\u00ednimo 3 \/ M\u00e1ximo 12<\/p>\n

                                      Tipo de oferecimento da disciplina: Presencial<\/p>\n

                                      Bibliografia:<\/p>\n

                                        \n
                                      • Berrar D, Granzow M, Dubitzky W. Fundamentals of Data Mining in Genomics and Proteomics. Springer US; 2007. doi:10.1007\/978-0-387-47509-7_1<\/li>\n
                                      • Tramontano A. Introduction to Bioinformatics – 1st Edition – Anna Tramontano – Loui. Chapman and Hall\/CRC; 2007. Accessed March 1, 2021. https:\/\/www.routledge.com\/Introduction-to-Bioinformatics\/Tramontano\/p\/book\/9781584885696<\/li>\n
                                      • van Dijk EL, Auger H, Jaszczyszyn Y, Thermes C. Ten years of next-generation sequencing technology. Trends Genet. 2014 Sep;30(9):418-26.<\/li>\n
                                      • Qing Y. Translational Bioinformatics and Systems Biology Methods for Personalized Medicine | ScienceDirect.; 2017. Accessed March 1, 2021. https:\/\/www.sciencedirect.com\/book\/9780128043288\/translational-bioinformatics-and-systems-biology-methods-for-personalized-medicine<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
                                        \n
                                        <\/i><\/i>MOT5754 – EFEITOS DA ATIVIDADE F\u00cdSICA NAS DOEN\u00c7AS REUM\u00c1TICAS<\/div>\n
                                        \n

                                        Docentes Respons\u00e1veis: Hamilton Augusto Roschel da Silva, Tiago Pe\u00e7anha de Oliveira
                                        \nCr\u00e9ditos: 2
                                        \nObjetivos:
                                        \nApresentar e debater as recomenda\u00e7\u00f5es mais recentes de atividade f\u00edsica em diferentes doen\u00e7as reum\u00e1ticas, bem como revisar os efeitos cl\u00ednicos da atividade f\u00edsica nestas doen\u00e7as.<\/p>\n

                                        Justificativa:
                                        \nA pr\u00e1tica de atividade f\u00edsica promove in\u00fameros benef\u00edcios para pacientes com doen\u00e7as reum\u00e1ticas; no entanto, uma grande parcela destes pacientes \u00e9 fisicamente inativa e\/ou sedent\u00e1ria. Parte desse problema se d\u00e1 pelo desconhecimento entre profissionais de sa\u00fade e pacientes dos benef\u00edcios e seguran\u00e7a da atividade f\u00edsica nesta popula\u00e7\u00e3o. Nos \u00faltimos anos, estudos bem controlados t\u00eam demonstrado efeitos ben\u00e9ficos de diferentes tipos de atividade f\u00edsica em par\u00e2metros cl\u00ednicos e no condicionamento f\u00edsico em pacientes com doen\u00e7as reum\u00e1ticas, dando suporte para a confec\u00e7\u00e3o de recomenda\u00e7\u00f5es m\u00e9dicas relacionadas a pr\u00e1tica de atividade f\u00edsica nesta popula\u00e7\u00e3o. Desta forma, torna-se necess\u00e1rio a revis\u00e3o desta literatura e a discuss\u00e3o do estado da arte sobre o papel da atividade f\u00edsica no tratamento das doen\u00e7as reum\u00e1ticas.<\/p>\n

                                        Conte\u00fado:
                                        \n– N\u00edvel de atividade f\u00edsica e comportamento sedent\u00e1rio nas doen\u00e7as reum\u00e1ticas
                                        \n– Barreiras e facilitadores para a pr\u00e1tica de atividade f\u00edsica nas doen\u00e7as reum\u00e1ticas
                                        \n– Efeitos da atividade f\u00edsica em par\u00e2metros cl\u00ednicos nas doen\u00e7as reum\u00e1ticas
                                        \n– Efeitos da atividade f\u00edsica no condicionamento cardiorrespirat\u00f3rio e muscular nas doen\u00e7as reum\u00e1ticas<\/p>\n

                                        Bibliografia:
                                        \nRausch Osthoff AK, Niedermann K, Braun J, et al. 2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis. Ann Rheum Dis. 2018;77(9):1251-1260. doi:10.1136\/annrheumdis-2018-213585
                                        \nSieczkowska SM, Smaira FI, Mazzolani BC, Gualano B, Roschel H, Pe\u00e7anha T. Efficacy of home-based physical activity interventions in patients with autoimmune rheumatic diseases: A systematic review and meta-analysis. Semin Arthritis Rheum. 2021;51(3):576-587. doi:10.1016\/j.semarthrit.2021.04.004<\/p>\n

                                        Pinto AJ, Roschel H, de S\u00e1 Pinto AL, et al. Physical inactivity and sedentary behavior: Overlooked risk factors in autoimmune rheumatic diseases? [published correction appears in Autoimmun Rev. 2022 Jan;21(1):102928]. Autoimmun Rev. 2017;16(7):667-674. doi:10.1016\/j.autrev.2017.05.001
                                        \nMessier SP, Mihalko SL, Beavers DP, Nicklas BJ, DeVita P, Carr JJ, Hunter DJ, Lyles M, Guermazi A, Bennell KL, Loeser RF. Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee Osteoarthritis: The START Randomized Clinical Trial. JAMA. 2021 Feb 16;325(7):646-657. doi: 10.1001\/jama.2021.0411. PMID: 33591346; PMCID: PMC7887656.
                                        \nPe\u00e7anha T, Bannell DJ, Sieczkowska SM, et al. Effects of physical activity on vascular function in autoimmune rheumatic diseases: a systematic review and meta-analysis. Rheumatology (Oxford). 2021;60(7):3107-3120. doi:10.1093\/rheumatology\/keab094
                                        \nAstley C, Pinto AJ, Bonf\u00e1 E, da Silva CAA, Gualano B. Gaps on rheumatologists’ knowledge of physical activity. Clin Rheumatol. 2021 Jul;40(7):2907-2911. doi: 10.1007\/s10067-020-05540-3. Epub 2021 Jan 13. PMID: 33438081.
                                        \nGualano B, Bonfa E, Pereira RMR, Silva CA. Physical activity for paediatric rheumatic diseases: standing up against old paradigms. Nat Rev Rheumatol. 2017;13(6):368-379. doi:10.1038\/nrrheum.2017.75
                                        \nFerraz RB, Gualano B, Rodrigues R, et al. Benefits of Resistance Training with Blood Flow Restriction in Knee Osteoarthritis. Med Sci Sports Exerc. 2018;50(5):897-905. doi:10.1249\/MSS.0000000000001530
                                        \nDassouki T, Benatti FB, Pinto AJ, et al. Objectively measured physical activity and its influence on physical capacity and clinical parameters in patients with primary Sj\u00f6gren’s syndrome. Lupus. 2017;26(7):690-697. doi:10.1177\/0961203316674819
                                        \nPerandini LA, de S\u00e1-Pinto AL, Roschel H, et al. Exercise as a therapeutic tool to counteract inflammation and clinical symptoms in autoimmune rheumatic diseases. Autoimmun Rev. 2012;12(2):218-224. doi:10.1016\/j.autrev.2012.06.007
                                        \nPinto AJ, Meireles K, Pe\u00e7anha T, et al. Acute cardiometabolic effects of brief active breaks in sitting for patients with rheumatoid arthritis. Am J Physiol Endocrinol Metab. 2021;321(6):E782-E794. doi:10.1152\/ajpendo.00259.2021
                                        \nForma de avalia\u00e7\u00e3o:
                                        \nOs alunos ser\u00e3o requisitados a apresentar semin\u00e1rios em t\u00f3picos selecionados pelos docentes.
                                        \nObservac\u00e3o:
                                        \nN\u00ba. m\u00ednimo de alunos= 4; N\u00ba. m\u00e1ximo de alunos= 20; N\u00ba. de alunos especiais = 2
                                        \nTipo de oferecimento da disciplina: N\u00e3o-Presencial<\/p>\n

                                        Informa\u00e7\u00f5es adicionais do oferecimento da disciplina:
                                        \nA porcentagem da disciplina que ocorrer\u00e1 no sistema n\u00e3o presencial (1- 100%).
                                        \n100%
                                        \nDetalhamento das atividades que ser\u00e3o presenciais e das que ser\u00e3o desenvolvidas via remota, com discrimina\u00e7\u00e3o do tempo de atividade cont\u00ednua online.
                                        \nTodas as atividades ser\u00e3o realizadas de maneira remota, online e s\u00edncrona.<\/p>\n

                                        Especifica\u00e7\u00e3o se as aulas, quando online, ser\u00e3o s\u00edncronas ou ass\u00edncronas.
                                        \nTodas as aulas ser\u00e3o s\u00edncronas.<\/p>\n

                                        Descri\u00e7\u00e3o do tipo de material e\/ou conte\u00fado que ser\u00e1 disponibilizado para o aluno e a A plataforma que ser\u00e1 utilizada.
                                        \nOs alunos ter\u00e3o acesso aos slides utilizados em aula e artigos. O Google Classroom e Google Meet ser\u00e3o utilizados como plataformas principais.<\/p>\n

                                        Defini\u00e7\u00e3o sobre a presen\u00e7a na Universidade e, quando necess\u00e1ria, discriminar quem dever\u00e1 estar presente (professora\/professor; aluna\/aluno; ambos).
                                        \nOs encontros ser\u00e3o realizados de maneira remota, via Google Meet. N\u00e3o haver\u00e1 necessidade de presen\u00e7a na Universidade.<\/p>\n

                                        Descri\u00e7\u00e3o dos tipos e da frequ\u00eancia de intera\u00e7\u00e3o entre aluna\/aluno e professora\/professor (somente durante as aulas; fora do per\u00edodo das aulas; hor\u00e1rios; por chat\/e-mail\/f\u00f3runs ou outro).
                                        \nA maior parte da intera\u00e7\u00e3o entre o professor e os alunos se dar\u00e1 nos momentos das aulas. Adicionalmente, os alunos poder\u00e3o contactar os professores fora do hor\u00e1rio das aulas por e-mail.
                                        \nA forma de controle da frequ\u00eancia nas aulas.
                                        \nChamada e registro de frequ\u00eancia via relat\u00f3rio do Google Meet.<\/p>\n

                                        Informa\u00e7\u00e3o sobre a obrigatoriedade ou n\u00e3o de disponibilidade de c\u00e2mera e \u00e1udio (microfone) por parte dos alunos.
                                        \n\u00c9 obrigat\u00f3rio o uso do microfone e c\u00e2mera nas apresenta\u00e7\u00f5es dos semin\u00e1rios.<\/p>\n

                                        A forma de avalia\u00e7\u00e3o da aprendizagem (presencial\/remota).
                                        \nA avalia\u00e7\u00e3o ser\u00e1 realizada a partir dos semin\u00e1rios apresentados em aula.<\/p>\n<\/div>\n<\/div>\n

                                        \n
                                        <\/i><\/i>MOT5755 – INOVA\u00c7\u00c3O EM ORTOPEDIA E TRAUMATOLOGIA<\/div>\n
                                        \n

                                        Docentes Respons\u00e1veis:\t Jorge Henrique Assun\u00e7\u00e3o, Camilo Partezani Helito , Alexandre Leme Godoy dos Santos
                                        \nCr\u00e9ditos:\t8
                                        \nObjetivos:
                                        \nApresentar aos alunos de p\u00f3s-gradua\u00e7\u00e3o o que temos de inova\u00e7\u00e3o em Ortopedia e Traumatologia;
                                        \nEstimular o empreendedorismo, racioc\u00ednio l\u00f3gico e a busca ativa por inova\u00e7\u00f5es que podem facilitar o diagn\u00f3stico e tratamento das afec\u00e7\u00f5es ortop\u00e9dicas;<\/p>\n

                                        Justificativa:
                                        \nVivemos em um mundo cada vez mais digital e onde novas tecnologias e inova\u00e7\u00f5es s\u00e3o incorporadas ao tratamento dos doentes mais rapidamente. Entretanto, no Brasil encontramos um ambiente onde o desenvolvimento das inova\u00e7\u00f5es e novas tecnologias \u00e9 pouco estimulado em rela\u00e7\u00e3o aos pa\u00edses mais desenvolvidos. Buscamos apresentar o que temos de inova\u00e7\u00e3o na Ortopedia e Traumatologia para os alunos de p\u00f3s-gradua\u00e7\u00e3o, estimulando o empreendedorismo e busca por novas solu\u00e7\u00f5es e tecnologias em Sa\u00fade.<\/p>\n

                                        Conte\u00fado:
                                        \nComo desenvolver uma inova\u00e7\u00e3o\/ Impress\u00e3o 3D na Ortopedia \/ Cirurgia rob\u00f3tica na Ortopedia e Traumatologia \/Telemedicina \/ Aplicativos e Wearables \/ Startups em Sa\u00fade e empreendedorismo \/ Engenharia tecidual e terapia celular nas les\u00f5es de cartilagem e artrose \/ Adjuvantes biol\u00f3gicos nas repara\u00e7\u00f5es das les\u00f5es tend\u00edneas \/ Intelig\u00eancia artificial \/ Advanced Data Science & Machine Learning<\/p>\n

                                        FORMATO E CRIT\u00c9RIOS DE AVALIA\u00c7\u00c3O:
                                        \nO programa ser\u00e1 oferecido em modalidade \u00e0 dist\u00e2ncia (100%) e as aulas ser\u00e3o ministradas por convidados nacionais ou internacionais refer\u00eancias no tema inova\u00e7\u00f5es em sa\u00fade.
                                        \nOs alunos participar\u00e3o de f\u00f3runs de discuss\u00e3o semanais sobre o tema da aula ministrada a partir de plataformas digitais. Prev\u00ea-se que os alunos interajam, postem e compartilhem artigos e outras informa\u00e7\u00f5es a fim de sedimentar o conhecimento a partir de metodologias ativas de aprendizado.
                                        \nA participa\u00e7\u00e3o dos alunos ser\u00e1 avaliada a partir da frequ\u00eancia nas atividades virtuais on-line s\u00edncronas (aulas e discuss\u00f5es de artigos, 30%), assim como a contagem de posts v\u00e1lidos e intera\u00e7\u00f5es ass\u00edncronas off-line durante a atividade semanal em grupo (70%). Alunos com menos de 85% de participa\u00e7\u00e3o nas atividades s\u00edncronas ser\u00e3o reprovados.<\/p>\n

                                        Bibliografia:
                                        \nImpress\u00e3o 3D na Ortopedia\/3D printing in Orthopedics
                                        \nDhawan A, Kennedy PM, Rizk E, Ozbolat IT. Three-dimensional Bioprinting forBone and Cartilage Restoration in Orthopaedic Surgery. J Am Acad Orthop Surg 2019;27:e215-e26.
                                        \nLi Z, Wang Q, Liu G. A Review of 3D Printed Bone Implants. Micromachines 2022; 13: 528.
                                        \nMeng M, Wang J, Sun T, Zhang W, Zhang J, Shu L, et al. Clinical applications and prospects of 3D printing guide templates in orthopaedics. Journal of Orthopaedic Translation 2022;32: 22\u201341.
                                        \nLi K, Liu Z, Li X, Wang J. 3D printing‐assisted surgery for proximal humerus fractures: a systematic review and meta‐analysis. Eur J Trauma Emerg Surg. 2022; 1: 1-11.
                                        \nWixted CM, Peterson JR, Kadakia RJ, Adams SB. Three-dimensional Printing in Orthopaedic Surgery: Current Applications and Future Developments. JAAOS Glob Res Rev 2021;5:1-11.
                                        \nZhang R, Lin J, Chen F, Liu W, Chen M. Clinical and radiological outcomes in three-dimensional printing assisted revision total hip and knee arthroplasty: a systematic review. Journal of Orthopaedic Surgery and Research 2021;16:495.
                                        \nKumar P, Vatsya P, Rajnish RK, Hooda A, Dhillon MS. Application of 3D Printing in Hip and Knee Arthroplasty: A Narrative Review. Indian Journal of Orthopaedics 2021; 55 (Suppl 1):S14\u2013S26.
                                        \nAlemayehu DG, Zhang Z, Tahir E, Gateau D, Zhang DF, Ma X. Preoperative Planning Using 3D Printing Technology in Orthopedic Surgery. BioMed Research International 2021:7940242.
                                        \nYang S, Lin HP, Luo C. Meta-Analysis of 3D Printing Applications in Traumatic Fractures. Front Surg 2021;8:696391.
                                        \nHuang, J, Xiong J, Wang D, Zhang J, Yang L; Sun S, et al. 3D Bioprinting of Hydrogels for Cartilage Tissue Engineering. Gels 2021; 7: 144.<\/p>\n

                                        Cirurgia rob\u00f3tica na Ortopedia e Traumatologia\/ Robotic surgery in Orthopedics and Traumatology
                                        \nInnocenti B, Bori E. Robotics in orthopaedic surgery: why, what and how? Archives of Orthopaedic and Trauma Surgery 2021; 141:2035\u201342.
                                        \nAlluri RK, Fedan Avrumova F, Sivaganesan A, Vaishnav AS, Lebl DR, Qureshi SA. Overview of Robotic Technology in Spine Surgery. HSS J 2021; 17:308-16.
                                        \nKunze KN, Bovonratwet P, Polce EM, Paul K, Sculco PK. Comparison of Surgical Time, Short-term Adverse Events, and Implant Placement Accuracy Between Manual, Robotic-assisted, and Computer-navigated Total Hip Arthroplasty: A Network Meta-analysis of Randomized Controlled Trials. JAAOS Glob Res Rev 2022;6: e21.00200.<\/p>\n

                                        Schuijt HJ, Hundersmarck D, Smeeing DPJ, Velde DV, Weaver MJ. Robot-assisted fracture fixation in orthopaedic trauma surgery: a systematic review. OTA Int 2021; 4:e153.
                                        \nBatailler C, Hannouche D, Benazzo F, Parratte S. Concepts and techniques of a new robotically assisted technique for total knee arthroplasty: the ROSA knee system. Archives of Orthopaedic and Trauma Surgery 2021;141:2049\u201358.<\/p>\n

                                        Telemedicina \/ Telemedicine
                                        \nPetersen W, Karpinski K, Backhaus L, Bierke S, Haner M. A systematic review about telemedicine in orthopedics. Archives of Orthopaedic and Trauma Surgery 2021; 141:1731\u20139.
                                        \nMcDonnell JM, Ahern DP, Ross TD, Gibbons D, Synnott KA, Butler JS. The efficacy of remote virtual care in comparison to traditional clinical visits for elective orthopaedic patients: A meta-analysis of prospective randomised controlled trials. Surgeon 2022; 20:177-86.
                                        \nPhuphanich ME, Sinha KR, Truongb M, Pham QG. Telemedicine for Musculoskeletal Rehabilitation and Orthopedic Postoperative Rehabilitation. Phys Med Rehabil Clin N Am 2021;32: 319\u201353.
                                        \nEmara KM, Diab RA, Amr M, Mahmoud SA, Nour M, Ahmed A , et al. Virtual orthopedic assessment: Main principles and specific regions. World J Orthop 2021; 12:672-84.
                                        \nHsu CH, Huang HT, Chen CH,Fu YC, Chou PH, Hsu NC. Global Impact of the COVID-19 Pandemic on Orthopedics and the Implications of Telemedicine: A Systematic Review of the Literature. J Clin Med 2022; 11:2983.<\/p>\n

                                        Aplicativos e Wearables\/ Apps and Wearables
                                        \nBerger‐Groch J, Keitsch M, Reiter A, Weiss S, Frosch KH, Priemel M. The Use of Mobile Applications for the Diagnosis and Treatment of Tumors in Orthopaedic Oncology \u2013 a Systematic Review. Journal of Medical Systems 2021; 45:99.
                                        \nShah NV, Gold R, Dar Q-A, Diebo BG, Paulino CB, Naziri Q. Smart Technology and Orthopaedic Surgery: Current Concepts Regarding the Impact of Smartphones and Wearable Technology on Our Patients and Practice. Curr Rev Musculoskelet Med 2021;14:378\u201391.
                                        \nSeng Juong Wong SJ, Greg A. Robertson GA, Connor KL, Brady RR, Wood AM. Smartphone apps for orthopaedic sports medicine \u2013 a smart move? BMC Sports Science, Medicine, and Rehabilitation 2015;7:23
                                        \nSmuck M, Odonkor CA, Wilt JK, Schmidt N, Swiernik MA. The emerging clinical role of wearables: factors for successful implementation in healthcare. Digital Medicine 2021;4:45.
                                        \nVan Velthoven MH, Smith J, Wells G, Brindley D. Digital health app development standards: a systematic review protocol. BMJ Open 2018;8:e022969.
                                        \nBai MY, Mobbs RJ, Walsh WR, Betteridge C. mHealth Apps for Enhanced Management of Spinal Surgery Patients: A Review. Front Surg; 7:573398.
                                        \nBahadori S, Collard S, Williams JM, Swain I. A review of current use of commercial wearable technology and smartphone apps with application in monitoring individuals following total hip replacement surgery. J Med Eng Technol 2020; 44:324-33.
                                        \nLu L, Zhang J, Xie Y, Gao F, Xu S, Wu X, et al. Wearable Health Devices in Health Care: Narrative Systematic Review. JMIR Mhealth Uhealth 2020;8:e18907.
                                        \nMaster H, Bley JA, Coronado RA, Robinette PE, White DK, Pennings JS, et al.Effects of physical activity interventions using wearables to improve objectively-measured and patient-reported outcomes in adults following orthopaedic surgical procedures: A systematic review. PLoS ONE 2022;17: e0263562.
                                        \nRobertson GAJ, Wong SJ, Brady RR, Subramanian AS. Smartphone apps for spinal surgery: is technology good or evil? Eur Spine J 2016;25:1355\u201362.<\/p>\n

                                        Engenharia tecidual e terapia celular nas les\u00f5es de cartilagem e artrose\/Tissue engineering and cell therapy in cartilage lesions and arthrosis
                                        \nKnapik DM, Evuarherhe Jr. A, Frank RM, Steinwachs M, Rodeo S, Mumme M, et al. Nonoperative and Operative Soft-Tissue and Cartilage Regeneration and Orthopaedic Biologics of the Knee: An Orthoregeneration Network (ON) Foundation Review. Arthroscopy 2021;37:2704-21.
                                        \nLouis ML, Dumonceau RG, Jouve E, Cohen M, Djouri R, Richardet N, et al. Intra-Articular Injection of Autologous Microfat and Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Double-Blind Randomized Comparative Study. Arthroscopy 2021;37:3125-37.
                                        \nCondron NB, Kester BS, Tokish JM, Zumstein MA, Gobezie R, Scheibel M, et al. Nonoperative and Operative Soft-Tissue, Cartilage, and Bony Regeneration and Orthopaedic Biologics of the Shoulder: An Orthoregeneration Network (ON) Foundation Review. Arthroscopy 2021;37:3200-18.
                                        \nPel\u00e1ez P, Dami\u00e1 E, Torres-Torrillas M, Chicharro D, Cuervo B, Miguel L, et al. Cell and Cell Free Therapies in Osteoarthritis. Biomedicines 2021;9:1726.
                                        \nHernigou J, Verdonk P, Homma Y, Verdonk R, Goodman SB, Hernigou P. Nonoperative and Operative Bone and Cartilage Regeneration and Orthopaedic Biologics of the Hip: An Orthoregeneration Network (ON) Foundation Hip Review. Arthroscopy 2022;38:643-56.
                                        \nHernigou J, Vertongen P, Rasschaert J, Hernigou P. Role of Scaffolds, Subchondral, Intra-Articular Injections of Fresh Autologous Bone Marrow Concentrate Regenerative Cells in Treating Human Knee Cartilage Lesions: Different Approaches and Different Results. Int J Mol Sci 2021; 22:3844.
                                        \nDamia E, Chicharro D, Lopez S, Cuervo B, Rubio M, Sopena JJ. Adipose-Derived Mesenchymal Stem Cells: Are They a Good Therapeutic Strategy for Osteoarthritis? Int J Mol Sci 2018,19:1926.
                                        \nTribe HC, McEwan J, Taylor H, Oreffo ROC, Tare RS. Mesenchymal Stem Cells: Potential Role in the Treatment of Osteochondral Lesions of the Ankle. Biotechnol J 2017;12:1700070.
                                        \nTrams E, Malesa K, Pomianowski S, Kaminski R. Role of Platelets in Osteoarthritis\u2014Updated Systematic Review and Meta-Analysis on the Role of Platelet-Rich Plasma in Osteoarthritis. Cells 2022;11:1080.<\/p>\n

                                        Adjuvantes biol\u00f3gicos nas repara\u00e7\u00f5es das les\u00f5es tend\u00edneas\/Biological adjuvants in tendon repair
                                        \nMilano G, S\u00e1nchez M, Jo CH, Saccomanno MF, Thampatty BP, Wang JHC. Platelet-rich plasma in orthopaedic sports medicine: state of the art. JISAKOS 2019;4:188\u2013195.
                                        \nNauwelaers AK, Oost LV, Peers K. Evidence for the use of PRP in chronic midsubstance Achilles tendinopathy: A systematic review with meta-analysis. Foot Ankle Surgery 2021; 27:486\u201395.
                                        \nBarman A, Sinha MK, Sahoo J, Jena D, Patel V, Patel S, et al. Platelet-rich plasma injection in the treatment of patellar tendinopathy: a systematic review and meta-analysis. Knee Surg Relat Res 2022;34:22.
                                        \nLavoie-Gagne O, Fury MS, Mehta N, Harkin WE, Bernstein DN, Berlinberg EJ. Double Row Repair with PRP Optimizes Retear Rates after Small to Medium Full-Thickness Rotator Cuff Repair: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. Arthroscopy 2022; 22:S0749-806.
                                        \nRandelli PS, Cucchi D, Fossati C, Boerci L, Nocerino E, Ambrogi F, et al. Arthroscopic Rotator Cuff Repair Augmentation With Autologous Microfragmented Lipoaspirate Tissue Is Safe and Effectively Improves Short-term Clinical and Functional Results. Am J Sports Med 2022;50:1344-57.
                                        \nMalavolta EA, Gracitelli MEC , Assun\u00e7\u00e3o JH, Ferreira Neto AA, Marcelo Bordalo-Rodrigues M, Camargo OP. Clinical and Structural Evaluations of Rotator Cuff Repair With and Without Added Platelet-Rich Plasma at 5-Year Follow-up: A Prospective Randomized Study. Am J Sports Med 2018;46:3134-41.
                                        \nKhan M, Shanmugaraj A, Prada C, Patel A, Babins E, Bhandari M. The Role of Hyaluronic Acid for Soft Tissue Indications: A Systematic Review and Meta-Analysis. Sports Health 2022;doi: 10.1177\/19417381211073316.
                                        \nCho WS, Chung SG, Kim W, Jo CH, Lee S-U, Lee SY. Mesenchymal Stem Cells Use in the Treatment of Tendon Disorders: A Systematic Review and Meta-Analysis of Prospective Clinical Studies. Ann Rehabil Med 2021;45:274-83.
                                        \nFilardo G, Di Matteo B, Kon E, Merli G, Marcacci M. Platelet‐rich plasma in tendon‐related disorders: results and indications. Knee Surg Sports Traumatol Arthrosc 2018;26:1984-99.
                                        \nGreiner S, Lawton R, Voss A. Cell‐based therapy of the elbow: evidence for lateral tendinopathy\u2014a review on current treatments. Knee Surg Sports Traumatol Arthrosc 2022 ;30:1152-60.
                                        \nHamid MSA, Sazlina SG. Platelet-rich plasma for rotator cuff tendinopathy: A systematic review and meta-analysis. PLoS ONe 16: e0251111.<\/p>\n

                                        Intelig\u00eancia artificial \/ Intelligence artificial\/ Advanced Data Science & Machine Learning
                                        \nLalehzarian SP, Gowd AK,Liu JN. Machine learning in orthopaedic surgery. World J Orthop 2021; 12: 685-99.
                                        \nMartin RK, Ley C, Pareek A, Groll A, Tischer T, Seil R. Artificial intelligence and machine learning: an introduction for orthopaedic surgeons. Knee Surgery, Sports Traumatology, Arthroscopy 2022;30:361\u20134.
                                        \nHornung AL, Hornung CM, Mallow GM, Barajas JN, Rush III A, Sayari , et al. Artificial intelligence in spine care: current applications and future utility. European Spine Journal 2022; doi: 10.1007\/s00586-022-07176-0. Online ahead of print.
                                        \nBatailler C, Shatrov J, Elliot Sappey‐Marinier E, Servien E, Parratte S, Lustig S. Artificial intelligence in knee arthroplasty: current concept of the available clinical applications. Arthroplasty 2022; 4:17
                                        \nShah RM, Wong C, Arpey NC, Patel AA, Divi SN. A Surgeon\u2019s Guide to Understanding Artificial Intelligence and Machine Learning Studies in Orthopaedic Surgery. Current Reviews in Musculoskeletal Medicine 2022;15:121\u201332.<\/p>\n

                                        Forma de avalia\u00e7\u00e3o:
                                        \nA participa\u00e7\u00e3o dos alunos ser\u00e1 avaliada a partir da frequ\u00eancia nas atividades virtuais on-line s\u00edncronas (aulas e discuss\u00f5es de artigos, 30%), assim como a contagem de posts v\u00e1lidos e intera\u00e7\u00f5es ass\u00edncronas off-line durante a atividade semanal em grupo (70%). Alunos com menos de 85% de participa\u00e7\u00e3o nas atividades s\u00edncronas ser\u00e3o reprovados.<\/p>\n

                                        Observa\u00e7\u00e3o:
                                        \nN\u00famero m\u00ednimo de alunos= 8 alunos; N\u00famero m\u00e1ximo de alunos= 32.<\/p>\n

                                        No Departamento de Ortopedia e Traumatologia temos em andamento diversos projetos com interface na inova\u00e7\u00e3o e outros projetos futuros que poder\u00e3o ser incorporados no dia a dia do Instituo, sendo alguns deles:<\/p>\n

                                        1. Transplante aut\u00f3logo de condrocitos
                                        \n2. Transplante osteocondral a fresco
                                        \n3. Projeto Centro Cir\u00fargico Inteligente
                                        \n4. Parceria LIM\/IPT\/EACH – Avalia\u00e7\u00e3o ergon\u00f4mica e seguran\u00e7a veicular
                                        \n5. Treinamento Exoesqueleto Free Walk
                                        \n6. EPIs COVID
                                        \n7. Projeto PRONA
                                        \n8. Sa\u00fade Digital IOT
                                        \n9. Laborat\u00f3rio de Tomografia Computadorizada com Carga para Membros inferiores – WBCT
                                        \n10. Impress\u00e3o 3D relacionada a planejamento e execu\u00e7\u00e3o cir\u00fargica
                                        \n11. Manual de fixa\u00e7\u00e3o externa
                                        \n12. Intelig\u00eancia Artificial na defini\u00e7\u00e3o de riscos e desfechos na S\u00edndrome do P\u00e9 Diab\u00e9tico<\/p>\n

                                        \u00c9 importante salientar que as aulas dessa disciplina ser\u00e3o ministradas n\u00e3o s\u00f3 pelos professores respons\u00e1veis, mas tamb\u00e9m por professores convidados nacionais e internacionais, de modo que todos os temas propostos, e ainda outras que venham a surgir, possam ser ministrados com excel\u00eancia.<\/p>\n

                                        Em rela\u00e7\u00e3o aos professores do curso, os projetos e \u00e1reas tem\u00e1ticas de ensino voltadas para os temas em quest\u00e3o s\u00e3o:
                                        \nProf. Alexandre Leme Godoy dos Santos
                                        \nTem atua\u00e7\u00e3o na \u00e1rea de cirurgia de p\u00e9 e tornozelo. \u00c9 Board Member da International WBCT Society.
                                        \nOs Projetos relacionados ao Laborat\u00f3rio Weight-Bearing Computed Tomography (WBCT) agrega os servi\u00e7os de Tornozelo e P\u00e9, Ortopedia Pedi\u00e1trica, Joelho, Reconstru\u00e7\u00e3o e Trauma Ortop\u00e9dico.<\/p>\n

                                        Nosso laborat\u00f3rio possui o \u00fanico aparelho de WBCT no Brasil e primeiro da Am\u00e9rica Latina; esse m\u00e9todo de aquisi\u00e7\u00e3o de imagem do sistema musculoesquel\u00e9ticoque permite a avalia\u00e7\u00e3o completa por imagem das articula\u00e7\u00f5es e rela\u00e7\u00f5es \u00f3sseas do p\u00e9, tornozelo, joelho e quadril, com sustenta\u00e7\u00e3o do peso corporal em posi\u00e7\u00e3o ortost\u00e1tica.<\/p>\n

                                        As possibilidades de inova\u00e7\u00e3o com essa ferramenta diagn\u00f3stica s\u00e3o in\u00fameras e relacionadas a decis\u00e3o terap\u00eautica, ao planejamento cir\u00fargico, ao acompanhamento p\u00f3s-operat\u00f3rio e de reabilita\u00e7\u00e3o, e, tamb\u00e9m, no desenvolvimento e aprimoramento de softwares para leitura semiautom\u00e1tica e autom\u00e1tica dos \u00e2ngulos e rela\u00e7\u00f5es osteo-articulares.<\/p>\n

                                        Alguns frutos desse grande projeto j\u00e1 est\u00e3o publicados na literatura:<\/p>\n

                                        de Cesar Netto C, Day J, Godoy-Santos AL, Roney A, Barbachan Mansur NS, Lintz F, Ellis SJ, Demetracopoulos CA. The use of three-dimensional biometric Foot and Ankle Offset to predict additional realignment procedures in total ankle replacement. Foot Ankle Surg. 2022 Oct;28(7):1029-1034. doi: 10.1016\/j.fas.2022.02.007. Epub 2022 Feb 16. PMID: 35190277.<\/p>\n

                                        Barbachan Mansur NS, Lalevee M, Maly C, Dibbern K, Lee HY, Godoy-Santos AL, Lintz F, de Cesar Netto C. Association Between Middle Facet Subluxation and Foot and Ankle Offset in Progressive Collapsing Foot Deformity. Foot Ankle Int. 2022 Jan;43(1):96-100. doi: 10.1177\/10711007211040820. Epub 2021 Sep 28. PMID: 34581232.<\/p>\n

                                        Lee HY, Mansur NS, Lalevee M, Maly C, Iehl CJ, Hembree WC, Godoy-Santos A, de Cesar Netto C. Does metatarsus primus elevatus really exist in hallux rigidus? A weightbearing CT case-control study. Arch Orthop Trauma Surg. 2023 Feb;143(2):755-761. doi: 10.1007\/s00402-021-04168-5. Epub 2021 Sep 9. PMID: 34505168.<\/p>\n

                                        Auch E, Barbachan Mansur NS, Alexandre Alves T, Cychosz C, Lintz F, Godoy-Santos AL, Baumfeld DS, de Cesar Netto C. Distal Tibiofibular Syndesmotic Widening in Progressive Collapsing Foot Deformity. Foot Ankle Int. 2021 Jun;42(6):768-775. doi: 10.1177\/1071100720982907. Epub 2021 Jan 29. PMID: 33508965.<\/p>\n

                                        L\u00f4bo CFT, Pires EA, Bordalo-Rodrigues M, de Cesar Netto C, Godoy-Santos AL. Imaging of progressive collapsing foot deformity with emphasis on the role of weightbearing cone beam CT. Skeletal Radiol. 2022 Jun;51(6):1127-1141. doi: 10.1007\/s00256-021-03942-1. Epub 2021 Oct 25. PMID: 34693455.<\/p>\n

                                        Godoy-Santos AL, Bernasconi A, Bordalo-Rodrigues M, Lintz F, L\u00f4bo CFT, de Cesar Netto C. Weight-bearing cone-beam computed tomography in the foot and ankle specialty: where we are and where we are going – an update. Radiol Bras. 2021 May-Jun;54(3):177-184. doi: 10.1590\/0100-3984.2020.0048. PMID: 34108765; PMCID: PMC8177673.<\/p>\n

                                        de Cesar Netto C, Shakoor D, Dein EJ, Zhang H, Thawait GK, Richter M, Ficke JR, Schon LC; Weightbearing CT International Study Group; Demehri S. Influence of investigator experience on reliability of adult acquired flatfoot deformity measurements using weightbearing computed tomography. Foot Ankle Surg. 2019 Aug;25(4):495-502. doi: 10.1016\/j.fas.2018.03.001. Epub 2018 Mar 12. PMID: 30321961.<\/p>\n

                                        de Cesar Netto C, Godoy-Santos AL, Saito GH, Lintz F, Siegler S, O’Malley MJ, Deland JT, Ellis SJ. Subluxation of the Middle Facet of the Subtalar Joint as a Marker of Peritalar Subluxation in Adult Acquired Flatfoot Deformity: A Case-Control Study. J Bone Joint Surg Am. 2019 Oct 16;101(20):1838-1844. doi: 10.2106\/JBJS.19.00073. PMID: 31626008.<\/p>\n

                                        Godoy-Santos AL, Cesar C NETTO; WEIGHT-BEARING CT INTERNATIONAL STUDY GROUP. WEIGHT-BEARING COMPUTED TOMOGRAPHY OF THE FOOT AND ANKLE: AN UPDATE AND FUTURE DIRECTIONS. Acta Ortop Bras. 2018 Mar-Apr;26(2):135-139. doi: 10.1590\/1413-785220182602188482. PMID: 29983632; PMCID: PMC6032618.<\/p>\n

                                        Prof. Camilo Partezani Helito<\/p>\n

                                        Atua na \u00e1rea de ensino e pesquisa da Cirurgia de joelho. Participa e tem publica\u00e7\u00f5es em projetos nacionais e internacionais, incluindo estudos multic\u00eantricos nas \u00e1reas de inova\u00e7\u00e3o em diagn\u00f3stico e tratamento de diversas patologias ortop\u00e9dicas, incluindo utiliza\u00e7\u00e3o de resson\u00e2ncia tri-dimensional e impress\u00e3o 3D para cirurgias ortop\u00e9dicas complexas, utiliza\u00e7\u00e3o de plataformas de for\u00e7a em estudos de reabilita\u00e7\u00e3o de cirurgias ligamentares do joelho, estudos em transplante de tecidos musculoesquel\u00e9ticos e estudos anat\u00f4micos com foco em avalia\u00e7\u00e3o de mecanorreceptores e atividades proprioceptivas. Na \u00e1rea de ensino tem experi\u00eancia com a utiliza\u00e7\u00e3o de realidade virtual para treinamento de residentes e fellows em cirurgias como artroplastia prim\u00e1rias e de revis\u00e3o. Seguem alguns artigos publicados sobre os temas:<\/p>\n

                                        Novaes, M., Carvalho, A., Sauer, J.F. et al. Postural control during single leg stance in individuals with clinical indication for combined reconstruction of the anterior cruciate and the anterolateral ligaments of the knee: a cross-sectional study. BMC Musculoskelet Disord 23, 383 (2022). https:\/\/doi.org\/10.1186\/s12891-022-05347-0<\/p>\n

                                        Saithna A, Helito CP, Vieira TD, Sonnery-Cottet B, Muramatsu K. The Anterolateral Ligament Has Limited Intrinsic Healing Potential: A Serial, 3-Dimensional\u2013Magnetic Resonance Imaging Study of Anterior Cruciate Ligament\u2013Injured Knees From the SANTI Study Group. The American Journal of Sports Medicine. 2021;49(8):2125-2135. doi:10.1177\/03635465211013015<\/p>\n

                                        Helito CP, Mozella AP, Varone BB, Demange MK, Gobbi RG, Minamoto STN, Cobra HAAB. Extensor mechanism transplantation after knee prosthesis: 70-month follow-up. Acta Ortop Bras. [online]. 2022;30(1)<\/p>\n

                                        Ejnisman L, Helito CP, Camargo AFF, Rocha BA, Baptista AM, Camargo OP. Three-dimensional printing in Orthopedics: where we stand and where we are heading. Acta Ortop Bras. [online]. 2021;29(4):223-227.<\/p>\n

                                        Diego Ariel de Lima, Camilo Partezani Helito, Lana Lacerda de Lima, Jos\u00e9 Alberto Dias Leite, Maria Luzete Costa Cavalcante, Study of the Nerve Endings and Mechanoreceptors of the Anterolateral Ligament of the Knee, Arthroscopy: The Journal of Arthroscopic & Related Surgery, Volume 35, Issue 10, 2019, Pages 2918-2927, ISSN 0749-8063<\/p>\n

                                        Koichi Muramatsu, Adnan Saithna, Hiroki Watanabe, Kana Sasaki, Kenta Yokosawa, Yudo Hachiya, Tatsuo Banno, Camilo Partezani Helito, Bertrand Sonnery-Cottet, Three-dimensional Magnetic Resonance Imaging of the Anterolateral Ligament of the Knee: An Evaluation of Intact and Anterior Cruciate Ligament\u2013Deficient Knees From the Scientific Anterior Cruciate Ligament Network International (SANTI) Study Group, Arthroscopy: The Journal of Arthroscopic & Related Surgery, Volume 34, Issue 7, 2018, Pages 2207-2217, ISSN 0749-8063,<\/p>\n

                                        T\u00edrico LEP, Demange MK, Santos LAU, et al. Development of a Fresh Osteochondral Allograft Program Outside North America. CARTILAGE. 2016;7(3):222-228. doi:10.1177\/1947603515618484<\/p>\n

                                        Dr. Jorge Henrique Assun\u00e7\u00e3o<\/p>\n

                                        Atua na \u00e1rea de ensino e pesquisa da Cirurgia do Ombro e Cotovelo. Participa em diversos projetos onde as possibilidades de inova\u00e7\u00e3o no diagn\u00f3stico, tratamento e preven\u00e7\u00e3o de diversas doen\u00e7as ortop\u00e9dicas \u00e9 uma preocupa\u00e7\u00e3o e muitas vezes, o escopo principal do estudo.
                                        \nProjetos envolvendo uso da telemedicina, de ortobiol\u00f3gicos, \u201cmachine learning\u201d e de polimorfismos gen\u00e9ticos na etiologia de diferentes doen\u00e7as do ombro e cotovelo tiveram nossa participa\u00e7\u00e3o. Entre eles podemos citar:
                                        \n1. Pinto GMR, Assun\u00e7\u00e3o JH, Santos MCLGD, Godoy-Santos AL, Gracitelli MEC, Malavolta EA, Silva FBAE, Neto AAF. THE POLYMORPHISM OF METALLOPROTEINASES 1 AND 13 AND POSTTRAUMATIC ELBOW STIFFNESS. Acta Ortop Bras. 2022 Jan 28;30(1):e253503.<\/p>\n

                                        2. Gracitelli MEC, Lobo FL, Malavolta EA, Assun\u00e7\u00e3o JH, Andrade-Silva FB, Ferreira Neto AA. Clinical Validation of the Glenoid Track Concept in Anterior Glenohumeral Instability. Rev Bras Ortop (Sao Paulo). 2022 Feb 15;57(4):612-618.<\/p>\n

                                        3. Malavolta EA, Gracitelli MEC, Assun\u00e7\u00e3o JH, Ferreira Neto AA, Bordalo-Rodrigues M, de Camargo OP. Clinical and Structural Evaluations of Rotator Cuff Repair With and Without Added Platelet-Rich Plasma at 5-Year Follow-up: A Prospective Randomized Study. Am J Sports Med. 2018 Nov;46(13):3134-3141.<\/p>\n

                                        4. Assun\u00e7\u00e3o JH, Godoy-Santos AL, Dos Santos MCLG, Malavolta EA, Gracitelli MEC, Ferreira Neto AA. Matrix Metalloproteases 1 and 3 Promoter Gene Polymorphism Is Associated With Rotator Cuff Tear. Clin Orthop Relat Res. 2017 Jul;475(7):1904-1910<\/p>\n

                                        5. Malavolta EA, Gracitelli ME, Ferreira Neto AA, Assun\u00e7\u00e3o JH, Bordalo-Rodrigues M, de Camargo OP. Platelet-rich plasma in rotator cuff repair: a prospective randomized study. Am J Sports Med. 2014 Oct;42(10):2446-54.<\/p>\n

                                        6. Alaiti RK, Valio CS, Assun\u00e7\u00e3o JH, Andrade-Silva FB, Gracitelli MEC, Malavolta EA. When rotator cuff repair may not be indicated: Machine Learning can Predict Non-Achievement of Clinically Significant Outcomes After Rotator Cuff Surgical Repair. Arthroscopy 2023 [no prelo<\/p>\n

                                        Tipo de oferecimento da disciplna: N\u00e3o-Presencial<\/p>\n

                                        Informa\u00e7\u00f5es adicionais do oferecimento da disciplina:
                                        \nA porcentagem da disciplina que ocorrer\u00e1 no sistema n\u00e3o presencial (1- 100%).
                                        \nA disciplina ser\u00e1 oferecida 100% n\u00e3o presencial<\/p>\n

                                        Detalhamento das atividades que ser\u00e3o presenciais e das que ser\u00e3o desenvolvidas via remota, com discrimina\u00e7\u00e3o do tempo de atividade cont\u00ednua online.
                                        \nConforme mencionado anteriormente, todas as atividades ser\u00e3o realizadas de forma n\u00e3o presencial, incluindo as aulas expositivas, apresenta\u00e7\u00e3o de artigos, discuss\u00e3o dos alunos nos f\u00f3runs e processo de avalia\u00e7\u00e3o.
                                        \nAs aulas online ter\u00e3o dura\u00e7\u00e3o de 1 hora a cada semana e as atividades de discuss\u00e3o de artigos e f\u00f3runs online ter\u00e3o a dura\u00e7\u00e3o de 2:00 horas a cada semana, totalizando 8 semanas de programa.<\/p>\n

                                        Especifica\u00e7\u00e3o se as aulas, quando online, ser\u00e3o s\u00edncronas ou ass\u00edncronas.
                                        \nAs aulas ministradas ser\u00e3o s\u00edncronas e as atividades do f\u00f3rum de discuss\u00e3o ser\u00e3o ass\u00edncronas.<\/p>\n

                                        Descri\u00e7\u00e3o do tipo de material e\/ou conte\u00fado que ser\u00e1 disponibilizado para o aluno e a plataforma que ser\u00e1 utilizada.
                                        \nA plataforma a ser utilizada e disponibilizada para os alunos ser\u00e1 o Google classroom e para as atividades s\u00edncronas o Google Meets. A cada semana, novos \u201cassingments\u201d como artigos cient\u00edficos e materiais para estudos ser\u00e3o disponibilizados na plataforma Google classroom para discuss\u00e3o ass\u00edncrona.<\/p>\n

                                        Defini\u00e7\u00e3o sobre a presen\u00e7a na Universidade e, quando necess\u00e1ria, discriminar quem dever\u00e1 estar presente (professora\/professor; aluna\/aluno; ambos).
                                        \nComo informado anteriormente, n\u00e3o est\u00e1 prevista a participa\u00e7\u00e3o presencial obrigat\u00f3ria nessa disciplina oferecida, tanto para professores quanto para alunos.<\/p>\n

                                        Descri\u00e7\u00e3o dos tipos e da frequ\u00eancia de intera\u00e7\u00e3o entre aluna\/aluno e professora\/professor (somente durante as aulas; fora do per\u00edodo das aulas; hor\u00e1rios; por chat\/e-mail\/f\u00f3runs ou outro).
                                        \nAs intera\u00e7\u00f5es e frequ\u00eancias ser\u00e3o contabilizadas pelos professores durante a atividade s\u00edncrona online da aula (lista de presen\u00e7a no chat do Google Meets a ser disponibilizado na metade da aula) e tamb\u00e9m a partir da contabiliza\u00e7\u00e3o dos posts v\u00e1lidos de coment\u00e1rios dos alunos nos f\u00f3runs de discuss\u00e3o ass\u00edncronos durante a semana.<\/p>\n<\/div>\n<\/div>\n

                                        \n
                                        <\/i><\/i>MOT5756 – EPIGEN\u00c9TICA NUTRICIONAL NAS DOEN\u00c7AS REUM\u00c1TICAS<\/div>\n
                                        \n

                                        Docentes Respons\u00e1veis: Bruno Gualano, Carolina Nicoletti Ferreira Fino
                                        \nCr\u00e9ditos:\t6\t<\/p>\n

                                        Objetivos:
                                        \nIntroduzir conceitos de epigen\u00e9tica nutricional com foco na obesidade e nas principais doen\u00e7as reum\u00e1ticas.<\/p>\n

                                        Justificativa:
                                        \nPretende-se com essa disciplina levar os alunos a conhecerem os princ\u00edpios de epigen\u00e9tica e da epigen\u00e9tica nutricional, focados na obesidade e doen\u00e7as reum\u00e1ticas. O melhor conhecimento dessa \u00e1rea por meio das novas tecnologias permite o entendimento das intera\u00e7\u00f5es entre genes e os nutrientes e assim, aplica\u00e7\u00e3o da medicina translacional, cujo objetivo \u00e9 levar a ci\u00eancia da bancada para a pr\u00e1tica cl\u00ednica para consequente melhoria na qualidade de vida dos pacientes.<\/p>\n

                                        Conte\u00fado:
                                        \nEm aulas te\u00f3ricas e semin\u00e1rios, os alunos ser\u00e3o capacitados a aprofundar seu conhecimento em conceitos: (a) Metila\u00e7\u00e3o do DNA; (b) Modifica\u00e7\u00f5es de histonas; (c) RNA n\u00e3o codificantes; (d) Epigen\u00e9tica e Obesidade; (e) Epigen\u00e9tica e Lupus Eritematoso Sist\u00eamico; (f) Epiegn\u00e9tica e Artrite Reumat\u00f3ide; (g) Epigen\u00e9tica e Psor\u00edase; (h) Nutri\u00e7\u00e3o Personalizada.<\/p>\n

                                        Bibliografia:
                                        \nTollefsbol T. Medical Epigenetics. Elsivier. 2nd Edition. 2021
                                        \nDal Bosco SM, Genro JP. Nutrigen\u00e9tica e Implica\u00e7oes na Sa\u00fade Humana. Editora Atheneu, 2014
                                        \nFarah SB. DNA segredos e mist\u00e9rios. Editora Sarvier, 2\u00aa edi\u00e7\u00e3o, 2007.
                                        \nKaput J, Rodriguez RL. Nutritional genomics. Discovering the path to personalized nutrition. Wiley, 2006.
                                        \nLucock M. Molecular nutrition and genomics. Nutrition and the ascent of human kind. Wiley, 2007.<\/p>\n

                                        Forma de avalia\u00e7\u00e3o:
                                        \nCRIT\u00c9RIOS DE AVALIA\u00c7\u00c3O: Os alunos ser\u00e3o avaliados por meio de apresenta\u00e7\u00e3o de semin\u00e1rios ao longo da disciplina e da participa\u00e7\u00e3o ativa nas discuss\u00f5es durante as apresenta\u00e7\u00f5es dos semin\u00e1rios.<\/p>\n

                                        Observa\u00e7\u00e3o:
                                        \n– Pr\u00e9-requisito: conhecimento da l\u00edngua inglesa para leitura de artigos cient\u00edficos.
                                        \n– Ser\u00e3o aceitos alunos especiais caso ainda existam vagas ap\u00f3s as matr\u00edculas dos alunos regulares.
                                        \n– Presen\u00e7a obrigat\u00f3ria: 75 %
                                        \n– N\u00famero de alunos: M\u00ednimo: 5 M\u00e1ximo: 20 Especiais: 2<\/p>\n

                                        Tipo de oferecimento da disciplina: Presencial<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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