{"id":2014,"date":"2022-07-25T09:12:08","date_gmt":"2022-07-25T12:12:08","guid":{"rendered":"https:\/\/www.musculoesqueleticousp.com.br\/?page_id=2014"},"modified":"2024-08-02T09:21:07","modified_gmt":"2024-08-02T12:21:07","slug":"carolina-nicoletti","status":"publish","type":"page","link":"https:\/\/www.musculoesqueleticousp.com.br\/es\/pesquisas\/orientadores\/carolina-nicoletti\/","title":{"rendered":"Carolina Nicoletti"},"content":{"rendered":"

\"\"<\/strong><\/p>\n

Titula\u00e7\u00e3o: <\/strong>P\u00f3s-Doutorado
\nE-mail:\u00a0<\/strong>carolina.nicoletti.ferreira@usp.br
\nLattes:\u00a0<\/strong>\u00a0http:\/\/lattes.cnpq.br\/3155405354051140<\/a>
\nOrcid: <\/strong>ID 0000-0002-4610-5786 – <\/strong>https:\/\/orcid.org\/0000-0002-4610-5786 <\/strong><\/a>
\nScopus<\/strong>:\u00a0ID 7004016534 – https:\/\/www.scopus.com\/authid\/detail.uri?authorId=7004016534 <\/a>
\nGoogle Scholar<\/strong>: cRz88dsAAAAJ –\u00a0 https:\/\/scholar.google.com.br\/citations?hl=pt-BR&user=<\/a> cRz88dsAAAAJ
\nResearch ID:<\/strong> J-2948-2015 – https:\/\/publons.com\/wos-op\/researcher\/2379552\/carolina-f-nicoletti<\/a><\/p>\n

 <\/p>\n

Linha de pesquisa <\/strong><\/h2>\n

Epigen\u00e9tica Nutricional nas Doen\u00e7as Reum\u00e1ticas<\/p>\n

Resumen<\/strong><\/h2>\n

La l\u00ednea de investigaci\u00f3n \u00abEpigen\u00e9tica Nutricional en Enfermedades Reum\u00e1ticas\u00bb tiene como objetivo elucidar si existe una firma epigen\u00e9tica relacionada con el fenotipo de lupus y obesidad. M\u00e1s espec\u00edficamente, investiga el papel de la obesidad en el patr\u00f3n de metilaci\u00f3n del ADN en esta enfermedad y si este perfil est\u00e1 asociado con las manifestaciones de la enfermedad, as\u00ed como si los tratamientos nutricionales, principalmente con nutrientes donadores de grupos metilo, pueden modular epigen\u00e9ticamente el genoma. Actualmente, estoy llevando a cabo estudios in vivo, in vitro y en humanos, lo que caracteriza un enfoque translacional. Colectivamente, esta ambiciosa y completa l\u00ednea de investigaci\u00f3n proporcionar\u00e1 nuevas ideas sobre la compleja relaci\u00f3n entre el lupus y la obesidad, ya que los avances en la medicina\/nutrici\u00f3n de precisi\u00f3n ser\u00e1n importantes para el tratamiento de pacientes con lupus, especialmente aquellos con obesidad.<\/p>\n

Principais publica\u00e7\u00f5es<\/strong><\/h2>\n
    \n
  1. Nicoletti CF, Cortes-Oliveira C, Noronha NY, Pinhel MAS, Dantas WS, J\u00e1come A, Marchini JS, Gualano B, Crujeiras AB, Nonino CB. DNA methylation pattern changes following a short-term hypocaloric diet in women with obesity. Eur J Clin Nutr. 2020;74(9):1345-1353. doi: 10.1038\/s41430-020-0660-1.<\/li>\n
  2. Nicoletti CF, Pinhel MAS, Noronha NY, de Oliveira BA, Salgado Junior W, J\u00e1come A, Diaz-Lagares A, Casanueva F, Crujeiras AB, Nonino CB. Altered pathways in methylome and transcriptome longitudinal analysis of normal weight and bariatric surgery women. Sci Rep. 2020;10(1): 6515. doi:10.1038\/s41598-020-60814-9.<\/li>\n
  3. Nicoletti CF, Pinhel MAS, Diaz-Lagares A, Casanueva FF, J\u00e1come A, Pinhanelli VC, de Oliveira BAP, Crujeiras AB, Nonino CB. DNA methylation screening after roux-en Y gastric bypass reveals the epigenetic signature stems from genes related to the surgery per se. BMC Med Genomics. 2019 May 27;12(1):72. doi: 10.1186\/s12920-019-0522-7.<\/li>\n
  4. Fraszczyk E, Luijten M, Spijkerman AMW, Snieder H, Wackers PFK, Bloks VW, Nicoletti CF, Nonino CB, Crujeiras AB, Buurman WA, Greve JW, Rensen SS, Wolffenbuttel BHR, van Vliet-Ostaptchouk JV. The effects of bariatric surgery on clinical profile, DNA methylation, and ageing in severely obese patients. Clin Epigenetics. 2020;12(1):14. doi: 10.1186\/s13148-019-0790-2.<\/li>\n
  5. Nicoletti CF, Nonino CB, de Oliveira BA, Pinhel MA, Mansego ML, Milagro FI,Zulet MA, Martinez JA. DNA Methylation and Hydroxymethylation Levels in Relationto Two Weight Loss Strategies: Energy-Restricted Diet or Bariatric Surgery. Obes Surg. 2016;26(3):603-11. doi: 10.1007\/s11695-015-1802-8.<\/li>\n<\/ol>\n

     <\/p>\n

    PROJETOS ORIENTADOR\/ LINHA<\/strong><\/h2>\n

    Linha 7. EFEITOS DO EXERC\u00cdCIO F\u00cdSICO, NUTRI\u00c7\u00c3O E GEN\u00c9TICA NA SA\u00daDE E NO DESEMPENHO F\u00cdSICO
    \n<\/strong>PROJETO CAROLINA NICOLETTI:<\/strong> ASSINATURAS EPIGEN\u00c9TICAS NO TECIDO ADIPOSO
    \nPROJETO CAROLINA NICOLETTI<\/strong>: GEN\u00d4MICA NUTRICIONAL NAS DOEN\u00c7AS CR\u00d4NICAS E\/OU REUM\u00c1TICAS<\/p>","protected":false},"excerpt":{"rendered":"

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