{"id":728,"date":"2020-07-07T21:26:48","date_gmt":"2020-07-08T00:26:48","guid":{"rendered":"http:\/\/www.musculoesqueleticousp.com.br\/?page_id=728"},"modified":"2024-06-18T16:58:01","modified_gmt":"2024-06-18T19:58:01","slug":"walcy-paganelli-rosolia-teodoro","status":"publish","type":"page","link":"https:\/\/www.musculoesqueleticousp.com.br\/en\/pesquisas\/orientadores\/walcy-paganelli-rosolia-teodoro\/","title":{"rendered":"Walcy Paganelli Rosolia Teodoro"},"content":{"rendered":"

\"\"T\u00edtulo:<\/strong> Post Doctor
\nE-mail: <\/strong>walcy.teodoro@fm.usp.br<\/a>
\nLattes:\u00a0<\/strong>http:\/\/lattes.cnpq.br\/2069814538238357<\/a>
\nOrcid: <\/strong>ID \u00a0<\/strong>0000-0001-7559-4542 – https:\/\/orcid.org\/0000-0001-7559-4542<\/a>
\nScopus:\u00a0<\/strong>ID 6602886287 – https:\/\/www.scopus.com\/authid\/detail.uri?authorId=660288628<\/a>
\nGoogle Scholar: <\/strong>ID bBBBYPIAAAAJ – https:\/\/scholar.google.com.br\/citations?user=bBBBYPIAAAAJ&hl=pt-BR&oi=ao<\/a>
\nResearch ID:\u00a0<\/strong>H-5133-2017 – https:\/\/publons.com\/researcher\/2112304\/walcy-rosolia-teodoro\/<\/a><\/p>\n

Line of research:<\/strong><\/h2>\n

Tissue and molecular aspects of the structure and function of extracellular matrix proteins in inflammatory and fibrotic processes<\/p>\n

Summary:<\/strong><\/h2>\n

The objective of our line of research is to investigate tissue and molecular aspects of the structure and function of extracellular matrix proteins, with emphasis on the different isoforms of collagen. It is known that collagen, in addition to being responsible for tissue structure, performs functions of cell adhesion, proliferation and migration and that together with the glycoproteins of the cell membrane can promote cellular signaling and immunogenicity. Uncontrolled gene expression synthesis from post-transcriptional changes or changes in essential transcription factors leads to defects in the differentiation and proliferation of cells that culminate in the activation of inflammatory and fibrotic processes present in degenerative autoimmune and osteoarticular diseases. Our proposal is to evaluate the inflammatory and osteoarticular process control mechanisms that culminate in the activation of the inflammatory process and cell proliferation and differentiation \u201cin vitro\u201d and \u201cin vivo\u201d in animals and humans, focusing on the applicability of the knowledge generated to future therapeutic and diagnostic tools.<\/p>\n

Relevant articles:<\/strong><\/h2>\n
    \n
  1. Barbosa AP, Louren\u00e7o JD, Junqueira JJM, Larissa Emidio de Fran\u00e7a S, Martins JS, Oliveira Junior MC, Begalli I, Velosa APP, Olivo CR, Bastos TB, Jorgetti V, Rodolfo de Paula V, Teodoro WR, Lopes FDTQS. The deleterious effects of smoking in bone mineralization and fibrillar matrix composition. Life Sci. 2020;241:117132. doi: 10.1016\/j.lfs.2019.117132.<\/li>\n
  2. Teodoro WR, de Jesus Queiroz ZA, Dos Santos LA, Catanozi S, Dos Santos Filho A, Bueno C, Vendramini MBG, Fernezlian SM, Eher EM, Sampaio-Barros PD, Pasoto SG, Lopes FDTQS, Velosa APP, Capelozzi VL. Proposition of a novel animal model of systemic sclerosis induced by type V collagen in C57BL\/6 mice that reproduces fibrosis, vasculopathy and autoimmunity. Arthritis Res Ther. 2019 ;21(1):278. doi: 10.1186\/s13075-019-2052-2.<\/li>\n
  3. Atayde SR, Velosa APP, Catanozi S, Del Bianco V, Andrade PC, Rodrigues JECM, Dos Santos Filho A, Antonangelo L, de Mello SBV, Capelozzi VL, Teodoro WR. Collagen V oral administration decreases inflammation and remodeling of synovial membrane in experimental arthritis. PLoS One. 2018 Jul 30;13(7):e0201106. doi: 10.1371\/journal.pone.0201106.<\/li>\n
  4. Akamatsu FE, Saleh SO, Hojaij F, Martinez CA, Andrade M, Teodoro WR, Jacomo AL. Radiofrequency preserves histoarchitecture and enhances collagen synthesis in experimental tendon injury. Histol Histopathol. 2016 May;31(5):515-22.<\/li>\n
  5. Atayde SA, Yoshinari NH, Nascimento DP, Catanozi S, Andrade PC, Velosa AP, Parra ER, Passarelli M, Nakandakare ER, Capelozzi VL, Teodoro WR. Experimental diabetes modulates collagen remodelling of joints in rats. Histol Histopathol. 2012 Nov;27(11):1471-9. doi: 10.14670\/HH-27.1471.<\/li>\n<\/ol>\n

     <\/p>\n

    PROJETOS ORIENTADOR\/ LINHA<\/strong><\/h2>\n

    Linha 4. OSTEOIMUNOLOGIA E AVALIA\u00c7\u00c3O DOS PROCESSOS DE REGENERA\u00c7\u00c3O M\u00daSCULOESQUEL\u00c9TICA
    \n<\/strong>PROJETO WALCY TEODORO:<\/strong> ESTUDOS DA REATIVIDADE DOS COMPONENTES DA MATRIZ EXTRACELULAR NAS DOEN\u00c7AS OSTEOARTICULARES E AUTOIMNUNES: EM MODELOS PR\u00c9-CL\u00cdNICOS E TERAP\u00caUTICOS
    \nPROJETO WALCY TEODORO:<\/strong> ESTUDOS SOBRE O PAPEL DO COL\u00c1GENO DO TIPO V NOS MECANISMOS DE REGENERA\u00c7\u00c3O E FIBR\u00d3TICOS<\/p>","protected":false},"excerpt":{"rendered":"

    T\u00edtulo: Post Doctor E-mail: walcy.teodoro@fm.usp.br Lattes:\u00a0http:\/\/lattes.cnpq.br\/2069814538238357 Orcid: ID \u00a00000-0001-7559-4542 – https:\/\/orcid.org\/0000-0001-7559-4542 Scopus:\u00a0ID 6602886287 – https:\/\/www.scopus.com\/authid\/detail.uri?authorId=660288628 Google Scholar: ID bBBBYPIAAAAJ – https:\/\/scholar.google.com.br\/citations?user=bBBBYPIAAAAJ&hl=pt-BR&oi=ao Research ID:\u00a0H-5133-2017 – https:\/\/publons.com\/researcher\/2112304\/walcy-rosolia-teodoro\/ Line […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":25,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-728","page","type-page","status-publish","hentry"],"yoast_head":"\nWalcy Paganelli Rosolia Teodoro - P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias do Sistema Musculoesquel\u00e9tico<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.musculoesqueleticousp.com.br\/pesquisas\/orientadores\/walcy-paganelli-rosolia-teodoro\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Walcy Paganelli Rosolia Teodoro - 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